permanent-ligation-left-anterior-descending-coronary-artery-mice

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Heart failure is a syndrome in which the heart fails to pump blood at a rate commensurate with cellular oxygen requirements at rest or during stress. It ...

in-vitro-vivo-model-to-study-bacterial-adhesion-to-vessel-wall-under

<em>In Vitro</em> and <em>In Vivo</em> Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

In order to cause endovascular infections and infective endocarditis, bacteria need to be able to adhere to the vessel wall while being exposed to the ...

Catholic University of Leuven

KU Leuven

To assess the effect of hypercholesterolemia on neointima formation and vascular remodelling after porcine coronary angioplasty.

Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty.

Ischemic preconditioning (IP) describes the adaptation of the myocardium to ischemic stress preceded by short periods of ischemia and reperfusion. However, its cardioprotective mechanisms are not completely understood. We assessed the effect of IP on ventricular energetics in an in-vivo sheep model.

Ischemic preconditioning reduces unloaded myocardial oxygen consumption in an in-vivo sheep model.

Hypercholesterolemia induces functional and structural changes of the microvasculature and reduces coronary flow reserve in humans and experimental animals. The effect of hypercholesterolemia on left ventricular (LV) function in the absence of coronary stenosis is, however, unknown. Our objective was therefore to assess the effect of hypercholesterolemia and cholesterol withdrawal on LV function in the presence of advanced coronary plaques that do not cause stenosis.

Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary density.

Cardiac arrest and cardiopulmonary resuscitation may result in multiorgan damage after global hypoxia due to neutrophil recruitment. Patients display all signs of a systemic inflammatory response syndrome. Reducing neutrophil recruitment may thus preserve organ function.

ArticleTotal : 2	Year
Publication title Cited by 48	2014
Publication title Cited by 13	2015

Article	Year
Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty. Cardiovascular research\| PubMed ID: 12123778	2002
Ischemic preconditioning reduces unloaded myocardial oxygen consumption in an in-vivo sheep model. Cardiovascular research\| PubMed ID: 12160961	2002
Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary density. Circulation\| PubMed ID: 12196342	2002
Intercellular adhesion molecule-1 inhibition attenuates neurologic and hepatic damage after resuscitation in mice. Anesthesiology\| PubMed ID: 16306726	2005

Marleen Lox

Biography

JoVE Journal Publications

Other Publications