Lee J. Martin

Division of Neuropathology, Johns Hopkins School of Medicine

Affiliated withJohns Hopkins School of Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 24	2014

Other Publications

Article	Year
Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent. Journal of neurobiology\| PubMed ID: 11810634	2002
Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons. Journal of neurotrauma\| PubMed ID: 11852982	2002
Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death. Journal of neurobiology\| PubMed ID: 11920724	2002
Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia. Brain research. Molecular brain research\| PubMed ID: 12117552	2002
Immature and mature cortical neurons engage different apoptotic mechanisms involving caspase-3 and the mitogen-activated protein kinase pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 12172379	2002
Rapid subcellular redistribution of Bax precedes caspase-3 and endonuclease activation during excitotoxic neuronal apoptosis in rat brain. Journal of neurotrauma\| PubMed ID: 12184852	2002
DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis. Neuromolecular medicine\| PubMed ID: 12230304	2002
DNA damage profiling in motor neurons: a single-cell analysis by comet assay. Neurochemical research\| PubMed ID: 12462407	2002
Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. Journal of neurochemistry\| PubMed ID: 12641745	2003
Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human. The Journal of comparative neurology\| PubMed ID: 12687705	2003
Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatric research\| PubMed ID: 12736390	2003
Nitration of the striatal Na,K-ATPase alpha3 isoform occurs in normal brain development but is not increased during hypoxia-ischemia in newborn piglets. Neurochemical research\| PubMed ID: 14649731	2003
Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. Journal of neuroscience methods\| PubMed ID: 15126043	2004
Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury. Neurobiology of disease\| PubMed ID: 15350969	2004
Pluripotent fates and tissue regenerative potential of adult olfactory bulb neural stem and progenitor cells. Journal of neurotrauma\| PubMed ID: 15672637	2004
In situ immunoradiographic method for quantification of specific proteins in normal and ischemic brain regions. Journal of neuroscience methods\| PubMed ID: 15814155	2005
Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16000635	2005
Apoptosis in perinatal hypoxic-ischemic brain injury: how important is it and should it be inhibited? Brain research. Brain research reviews\| PubMed ID: 16216332	2005
Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage. Journal of neuroscience research\| PubMed ID: 16247803	2005
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16399671	2006
The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain. The Journal of comparative neurology\| PubMed ID: 16736475	2006
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17093100	2006
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. The Journal of comparative neurology\| PubMed ID: 17099894	2007
Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology\| PubMed ID: 17146283	2006
Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 17213860	2007
Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degene... Reviews in the neurosciences\| PubMed ID: 17593875	2007
Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiology of aging\| PubMed ID: 17599696	2007
Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 17950559	2008
Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mi... Journal of neuropathology and experimental neurology\| PubMed ID: 17984682	2007
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18305234	2008
DNA damage and repair: relevance to mechanisms of neurodegeneration. Journal of neuropathology and experimental neurology\| PubMed ID: 18431258	2008
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 18820287	2009
Delayed neural network degeneration after neonatal hypoxia-ischemia. Annals of neurology\| PubMed ID: 19067347	2008
Glycinergic innervation of motoneurons is deficient in amyotrophic lateral sclerosis mice: a quantitative confocal analysis. The American journal of pathology\| PubMed ID: 19116365	2009
The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Experimental neurology\| PubMed ID: 19272377	2009
The mitochondrial permeability transition pore: a molecular target for amyotrophic lateral sclerosis therapy. Biochimica et biophysica acta\| PubMed ID: 19651206	2010
Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). Journal of Alzheimer's disease : JAD\| PubMed ID: 19661626	2009
Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degene... Experimental neurology\| PubMed ID: 19883643	2010
Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice. Brain structure & function\| PubMed ID: 19888600	2010
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human molecular genetics\| PubMed ID: 20185556	2010
Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Human molecular genetics\| PubMed ID: 20223753	2010
Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis. Journal of Alzheimer's disease : JAD\| PubMed ID: 20413846	2010
Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20571523	2011
Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. IDrugs : the investigational drugs journal\| PubMed ID: 20721828	2010
The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21209222	2011
Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 21258649	2010
An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity... Toxicologic pathology\| PubMed ID: 21378209	2011
Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21414903	2011
Neuronal cell death in neonatal hypoxia-ischemia. Annals of neurology\| PubMed ID: 21520238	2011
Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum. Neurobiology of disease\| PubMed ID: 21558004	2011
Motoneuron subtypes show specificity in glycine receptor channel abnormalities in a transgenic mouse model of amyotrophic lateral sclerosis. Channels (Austin, Tex.)\| PubMed ID: 21558795	2011
Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone. Developmental neuroscience\| PubMed ID: 21701140	2011
Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrop... Molecular neurodegeneration\| PubMed ID: 22047141	2011
Inhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis. Molecular neurobiology\| PubMed ID: 22072396	2012
Mitochondrial pathobiology in ALS. Journal of bioenergetics and biomembranes\| PubMed ID: 22083126	2011
Epigenetic regulation of motor neuron cell death through DNA methylation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22090490	2011
Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice. Journal of neuropathology and experimental neurology\| PubMed ID: 22249462	2012
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. Journal of neurochemistry\| PubMed ID: 22251169	2012
Biology of mitochondria in neurodegenerative diseases. Progress in molecular biology and translational science\| PubMed ID: 22482456	2012
Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury. Neurology research international\| PubMed ID: 22666585	2012
Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs. Anesthesia and analgesia\| PubMed ID: 22745113	2012
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23860373	2013
Aberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 23900692	2013
Imaging neurodegeneration in the mouse hippocampus after neonatal hypoxia-ischemia using oscillating gradient diffusion MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 24123409	2014
The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells. PloS one\| PubMed ID: 24278384	2013
Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice. Neurobiology of aging\| PubMed ID: 24325796	2014
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Frontiers in cellular neuroscience\| PubMed ID: 24399935	2013
Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PloS one\| PubMed ID: 24667816	2014
Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties. Stem cells and development\| PubMed ID: 25027006	2014
Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia-ischemia injured mouse brains. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 25168861	2014
The non-human primate striatum undergoes marked prolonged remodeling during postnatal development. Frontiers in cellular neuroscience\| PubMed ID: 25294985	2014