Martin Friedlander

Department of Cell and Molecular Biology, The Scripps Research Institute

Affiliated withThe Scripps Research Institute Lowy Medical Research Institute

Research Area

Developmental BiologyMedicineImmunology and InfectionBioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 21	2015
Publication title Cited by 32	2015
Publication title Cited by 4	2016
Publication title Cited by 15	2021

Other Publications

Article	Year
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11773625	2002
A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11773626	2002
Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. The Journal of biological chemistry\| PubMed ID: 11856728	2002
Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12032304	2002
The amino terminus of opsin translocates "posttranslationally" as efficiently as cotranslationally. Biochemistry\| PubMed ID: 12056902	2002
Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nature medicine\| PubMed ID: 12145646	2002
Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion. Investigative ophthalmology & visual science\| PubMed ID: 12407162	2002
Co-translational targeting and translocation of the amino terminus of opsin across the endoplasmic membrane requires GTP but not ATP. The Journal of biological chemistry\| PubMed ID: 12486130	2003
In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12573615	2003
Endothelial proliferation in diabetic retinal microaneurysms. Archives of ophthalmology\| PubMed ID: 12742861	2003
Mouse model of subretinal neovascularization with choroidal anastomosis. Retina (Philadelphia, Pa.)\| PubMed ID: 12972764	2003
Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina. Blood\| PubMed ID: 14726407	2004
Global gene expression analysis of the developing postnatal mouse retina. Investigative ophthalmology & visual science\| PubMed ID: 14985324	2004
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nature medicine\| PubMed ID: 15098027	2004
Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circulation research\| PubMed ID: 15308581	2004
Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. The Journal of clinical investigation\| PubMed ID: 15372100	2004
Identifying potential regulators of infantile hemangioma progression through large-scale expression analysis: a possible role for the immune system and indoleamine 2,3 dioxygenase (IDO) duri... Lymphatic research and biology\| PubMed ID: 15624557	2003
Retinal vascular regeneration. Seminars in ophthalmology\| PubMed ID: 15804843	2005
Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease. Investigative ophthalmology & visual science\| PubMed ID: 16123396	2005
Recent progress in our understanding of the pathogenesis of infantile hemangiomas. Lymphatic research and biology\| PubMed ID: 16379591	2005
Myeloid cells in infantile hemangioma. The American journal of pathology\| PubMed ID: 16436675	2006
A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. The Journal of clinical investigation\| PubMed ID: 16498499	2006
Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina. Progress in retinal and eye research\| PubMed ID: 16515881	2006
T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Investigative ophthalmology & visual science\| PubMed ID: 16639024	2006
Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Molecular vision\| PubMed ID: 16735995	2006
Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. The Journal of clinical investigation\| PubMed ID: 17111048	2006
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17210921	2007
Ocular neovascularization: basic mechanisms and therapeutic advances. Survey of ophthalmology\| PubMed ID: 17240254	2007
Fibrosis and diseases of the eye. The Journal of clinical investigation\| PubMed ID: 17332885	2007
Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17363687	2007
Progenitor cells and retinal angiogenesis. Angiogenesis\| PubMed ID: 17372851	2007
Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. Journal of cardiac failure\| PubMed ID: 17517353	2007
Pathogenesis of infantile haemangioma: new molecular and cellular insights. Expert reviews in molecular medicine\| PubMed ID: 18045510	2007
Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. The Journal of clinical investigation\| PubMed ID: 18483622	2008
Introducing Lois E. H. Smith, the 2008 recipient of the Friedenwald Award. Investigative ophthalmology & visual science\| PubMed ID: 18708612	2008
Chapter 6. Ocular models of angiogenesis. Methods in enzymology\| PubMed ID: 19007663	2008
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. The Journal of clinical investigation\| PubMed ID: 19188685	2009
Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia\| PubMed ID: 19544395	2010
Combination angiostatic therapies: targeting multiple angiogenic pathways. Retina (Philadelphia, Pa.)\| PubMed ID: 19553794	2009
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia\| PubMed ID: 20544853	2010
Stemming vision loss with stem cells. The Journal of clinical investigation\| PubMed ID: 20811157	2010
Analysis of candidate genes for macular telangiectasia type 2. Molecular vision\| PubMed ID: 21179236	2010
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye. The Journal of cell biology\| PubMed ID: 22084310	2011
Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy. Scientific reports\| PubMed ID: 22355595	2011
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells. Stem cells translational medicine\| PubMed ID: 22532929	2012
Advances in treatment and management: immunologic and cell-based regenerative therapies. Investigative ophthalmology & visual science\| PubMed ID: 22562853	2012
Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells. Investigative ophthalmology & visual science\| PubMed ID: 22871841	2012
Targeted deletion of Vegfa in adult mice induces vision loss. The Journal of clinical investigation\| PubMed ID: 23093773	2012
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. The Journal of clinical investigation\| PubMed ID: 24084735	2013
Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina. Advances in experimental medicine and biology\| PubMed ID: 24664708	2014
Utilizing stem cell-derived RPE cells as a therapeutic intervention for age-related macular degeneration. Advances in experimental medicine and biology\| PubMed ID: 24664714	2014
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO molecular medicine\| PubMed ID: 24705878	2014
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature communications\| PubMed ID: 25601659	2015
Neurovascular crosstalk between interneurons and capillaries is required for vision. The Journal of clinical investigation\| PubMed ID: 25915585	2015
Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 26299572	2015
Global metabolomics reveals metabolic dysregulation in ischemic retinopathy. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 26617478	2016
A Challenging Form of Non-autoimmune Insulin-Dependent Diabetes in a Wolfram Syndrome Patient with a Novel Sequence Variant. Journal of diabetes & metabolism\| PubMed ID: 26819810	2015
iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study. Stem cells international\| PubMed ID: 26880994	2016
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nature medicine\| PubMed ID: 26974308	2016
Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. eLife\| PubMed ID: 26978795	2016
Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nature medicine\| PubMed ID: 27270778	2016
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy. Investigative ophthalmology & visual science\| PubMed ID: 27494343	2016
Quantitative metabolomics of photoreceptor degeneration and the effects of stem cell-derived retinal pigment epithelium transplantation. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences\| PubMed ID: 27644974	2016
VEGF regulates local inhibitory complement proteins in the eye and kidney. The Journal of clinical investigation\| PubMed ID: 27918307	2017
CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect. JCI insight\| PubMed ID: 28138561	2017
Genome-wide analyses identify common variants associated with macular telangiectasia type 2. Nature genetics\| PubMed ID: 28250457	2017
Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling. Circulation\| PubMed ID: 28356444	2017
Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative. Ophthalmology\| PubMed ID: 28365209	2017
Angiogenesis and Eye Disease. Annual review of vision science\| PubMed ID: 28532369	2015
Global Connections to Study Idiopathic Macular Telangiectasia Type 2. Retina (Philadelphia, Pa.)\| PubMed ID: 29190235	2018
Fully automated, deep learning segmentation of oxygen-induced retinopathy images. JCI insight\| PubMed ID: 29263301	2017
Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial. Ophthalmology\| PubMed ID: 30292541	2019
Metabolomics in the study of retinal health and disease. Progress in retinal and eye research\| PubMed ID: 30423446	2019
miR-30a-5p inhibition promotes interaction of Fas endothelial cells and FasL microglia to decrease pathological neovascularization and promote physiological angiogenesis. Glia\| PubMed ID: 30484883	2019
The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia. Neurochemistry international\| PubMed ID: 31199961	2019
Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily better. The Journal of clinical investigation\| PubMed ID: 31232702	2019
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. The New England journal of medicine\| PubMed ID: 31509666	2019
Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome. Ophthalmology\| PubMed ID: 32019699	2020
Retinal microglia are critical for subretinal neovascular formation. JCI insight\| PubMed ID: 32437334	2020
Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2. The British journal of ophthalmology\| PubMed ID: 32513667	2020
Systemic lipid dysregulation is a risk factor for macular neurodegenerative disease. Scientific reports\| PubMed ID: 32699277	2020
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10. Investigative ophthalmology & visual science\| PubMed ID: 32780864	2020
An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33106407	2020
Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2. The British journal of ophthalmology\| PubMed ID: 33229343	2020
WITHDRAWN: Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2. Retina (Philadelphia, Pa.)\| PubMed ID: 33230067	2020
Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2. Retina (Philadelphia, Pa.)\| PubMed ID: 33438900	2021
Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder. Communications biology\| PubMed ID: 33654266	2021