Eric S. Lander

Broad Institute of Harvard and Massachusetts Institute of Technology

Affiliated withBroad Institute of Harvard and Massachusetts Institute of Technology Harvard Medical School Massachusetts Institute of Technology

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 504	2010

Other Publications

Article	Year
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature genetics\| PubMed ID: 11731795	2002
ARACHNE: a whole-genome shotgun assembler. Genome research\| PubMed ID: 11779843	2002
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nature medicine\| PubMed ID: 11786909	2002
Human macrophage activation programs induced by bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11805289	2002
Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature\| PubMed ID: 11807556	2002
On the sequencing of the human genome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11880605	2002
The structure of haplotype blocks in the human genome. Science (New York, N.Y.)\| PubMed ID: 12029063	2002
Gene expression correlates of clinical prostate cancer behavior. Cancer cell\| PubMed ID: 12086878	2002
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer cell\| PubMed ID: 12086890	2002
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome research\| PubMed ID: 12097339	2002
Human genome sequence variation and the influence of gene history, mutation and recombination. Nature genetics\| PubMed ID: 12161752	2002
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12235366	2002
Detecting recent positive selection in the human genome from haplotype structure. Nature\| PubMed ID: 12397357	2002
Detection of regulatory variation in mouse genes. Nature genetics\| PubMed ID: 12410233	2002
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12438646	2002
Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci. Inflammatory bowel diseases\| PubMed ID: 12454612	2002
Initial sequencing and comparative analysis of the mouse genome. Nature\| PubMed ID: 12466850	2002
The mosaic structure of variation in the laboratory mouse genome. Nature\| PubMed ID: 12466852	2002
A molecular signature of metastasis in primary solid tumors. Nature genetics\| PubMed ID: 12469122	2003
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature genetics\| PubMed ID: 12524541	2003
Whole-genome sequence assembly for mammalian genomes: Arachne 2. Genome research\| PubMed ID: 12529310	2003
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12529507	2003
More on the sequencing of the human genome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12631699	2003
Pathogen discovery from human tissue by sequence-based computational subtraction. Genomics\| PubMed ID: 12659816	2003
The genome sequence of the filamentous fungus Neurospora crassa. Nature\| PubMed ID: 12712197	2003
Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature\| PubMed ID: 12748633	2003
IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. American journal of human genetics\| PubMed ID: 12776251	2003
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature genetics\| PubMed ID: 12808457	2003
Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts. Genome biology\| PubMed ID: 12844359	2003
An integrated haplotype map of the human major histocompatibility complex. American journal of human genetics\| PubMed ID: 12920676	2003
Position specific variation in the rate of evolution in transcription factor binding sites. BMC evolutionary biology\| PubMed ID: 12946282	2003
Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. Journal of autoimmunity\| PubMed ID: 14624755	2003
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell\| PubMed ID: 14651853	2003
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature\| PubMed ID: 15004568	2004
Genetic dissection of complex traits with chromosome substitution strains of mice. Science (New York, N.Y.)\| PubMed ID: 15031436	2004
Assessing the impact of population stratification on genetic association studies. Nature genetics\| PubMed ID: 15052270	2004
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15100410	2004
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Human molecular genetics\| PubMed ID: 15238506	2004
Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains. Endocrinology\| PubMed ID: 15284200	2004
Methods in comparative genomics: genome correspondence, gene identification and regulatory motif discovery. Journal of computational biology : a journal of computational molecular cell biology\| PubMed ID: 15285895	2004
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiological genomics\| PubMed ID: 15328390	2004
Transcriptional regulatory code of a eukaryotic genome. Nature\| PubMed ID: 15343339	2004
Eric S. Lander. Nature reviews. Drug discovery\| PubMed ID: 15368656	2004
Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. Genetics\| PubMed ID: 15371360	2005
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci. American journal of medical genetics. Part A\| PubMed ID: 15386476	2004
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature\| PubMed ID: 15496914	2004
A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice. Genetics\| PubMed ID: 15579706	2004
Genomic maps and comparative analysis of histone modifications in human and mouse. Cell\| PubMed ID: 15680324	2005
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature\| PubMed ID: 15735639	2005
A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. American journal of human genetics\| PubMed ID: 15747258	2005
An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15778292	2005
Assembly of polymorphic genomes: algorithms and application to Ciona savignyi. Genome research\| PubMed ID: 16077012	2005
A high-density screen for linkage in multiple sclerosis. American journal of human genetics\| PubMed ID: 16080120	2005
DNA sequence and analysis of human chromosome 18. Nature\| PubMed ID: 16177791	2005
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16199517	2005
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic acids research\| PubMed ID: 16224102	2005
The case for selection at CCR5-Delta32. PLoS biology\| PubMed ID: 16248677	2005
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature\| PubMed ID: 16341006	2005
Searching for signals of evolutionary selection in 168 genes related to immune function. Human genetics\| PubMed ID: 16362345	2006
DNA sequence and analysis of human chromosome 8. Nature\| PubMed ID: 16421571	2006
A large family of ancient repeat elements in the human genome is under strong selection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16477033	2006
Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature\| PubMed ID: 16554811	2006
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell\| PubMed ID: 16564017	2006
Analysis of the DNA sequence and duplication history of human chromosome 15. Nature\| PubMed ID: 16572171	2006
Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature\| PubMed ID: 16612386	2006
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature\| PubMed ID: 16625196	2006
Identification and classification of conserved RNA secondary structures in the human genome. PLoS computational biology\| PubMed ID: 16628248	2006
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell\| PubMed ID: 16630819	2006
Genetic evidence for complex speciation of humans and chimpanzees. Nature\| PubMed ID: 16710306	2006
A family of conserved noncoding elements derived from an ancient transposable element. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16864796	2006
Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature methods\| PubMed ID: 16929317	2006
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.)\| PubMed ID: 17008526	2006
A second fatty acid amide hydrolase with variable distribution among placental mammals. The Journal of biological chemistry\| PubMed ID: 17015445	2006
Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida. Nature\| PubMed ID: 17051155	2006
Chromosome substitution strains: a new way to study genetically complex traits. Methods in molecular medicine\| PubMed ID: 17071995	2006
A genome-wide map of diversity in Plasmodium falciparum. Nature genetics\| PubMed ID: 17159979	2007
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals of neurology\| PubMed ID: 17252545	2007
The mammalian epigenome. Cell\| PubMed ID: 17320505	2007
Sleep-related epilepsy in the A/J mouse. Sleep\| PubMed ID: 17326542	2007
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17442748	2007
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature\| PubMed ID: 17495919	2007
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome research\| PubMed ID: 17567995	2007
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature\| PubMed ID: 17571346	2007
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell\| PubMed ID: 17574021	2007
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature\| PubMed ID: 17603471	2007
Risk alleles for multiple sclerosis identified by a genomewide study. The New England journal of medicine\| PubMed ID: 17660530	2007
Comment on "The consensus coding sequences of human breast and colorectal cancers". Science (New York, N.Y.)\| PubMed ID: 17872428	2007
Efficient mapping of mendelian traits in dogs through genome-wide association. Nature genetics\| PubMed ID: 17906626	2007
Genome-wide detection and characterization of positive selection in human populations. Nature\| PubMed ID: 17943131	2007
Characterizing the cancer genome in lung adenocarcinoma. Nature\| PubMed ID: 17982442	2007
28-way vertebrate alignment and conservation track in the UCSC Genome Browser. Genome research\| PubMed ID: 17984227	2007
Distinguishing protein-coding and noncoding genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18040051	2007
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18077431	2007
Quality scores and SNP detection in sequencing-by-synthesis systems. Genome research\| PubMed ID: 18212088	2008
ALLPATHS: de novo assembly of whole-genome shotgun microreads. Genome research\| PubMed ID: 18340039	2008
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer research\| PubMed ID: 18483246	2008
Dissecting direct reprogramming through integrative genomic analysis. Nature\| PubMed ID: 18509334	2008
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature\| PubMed ID: 18600261	2008
Somatic mutations affect key pathways in lung adenocarcinoma. Nature\| PubMed ID: 18948947	2008
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS genetics\| PubMed ID: 18974828	2008
Genetic mapping in human disease. Science (New York, N.Y.)\| PubMed ID: 18988837	2008
Sequencing the nuclear genome of the extinct woolly mammoth. Nature\| PubMed ID: 19020620	2008
High-resolution mapping of copy-number alterations with massively parallel sequencing. Nature methods\| PubMed ID: 19043412	2009
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19066216	2008
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome biology\| PubMed ID: 19077304	2008
Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nature methods\| PubMed ID: 19079253	2009
Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19091943	2008
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature\| PubMed ID: 19182780	2009
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nature biotechnology\| PubMed ID: 19182786	2009
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19571010	2009
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer cell\| PubMed ID: 19573809	2009
Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell\| PubMed ID: 19682730	2009
Assisted assembly: how to improve a de novo genome assembly by using related species. Genome biology\| PubMed ID: 19712469	2009
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (New York, N.Y.)\| PubMed ID: 19815776	2009
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature\| PubMed ID: 19847166	2009
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS biology\| PubMed ID: 20016685	2009
A composite of multiple signals distinguishes causal variants in regions of positive selection. Science (New York, N.Y.)\| PubMed ID: 20056855	2010
Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nature methods\| PubMed ID: 20062050	2010
CK1epsilon is required for breast cancers dependent on beta-catenin activity. PloS one\| PubMed ID: 20126544	2010
Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 20127486	2010
The landscape of somatic copy-number alteration across human cancers. Nature\| PubMed ID: 20164920	2010
Integrative analysis of the melanoma transcriptome. Genome research\| PubMed ID: 20179022	2010
International network of cancer genome projects. Nature\| PubMed ID: 20393554	2010
Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs. Nature biotechnology\| PubMed ID: 20436462	2010
A draft sequence of the Neandertal genome. Science (New York, N.Y.)\| PubMed ID: 20448178	2010
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Cell stem cell\| PubMed ID: 20569696	2010
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature genetics\| PubMed ID: 20601955	2010
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell\| PubMed ID: 20673990	2010
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20713713	2010
Comparative epigenomic analysis of murine and human adipogenesis. Cell\| PubMed ID: 20887899	2010
Prepare and inspire. Science (New York, N.Y.)\| PubMed ID: 20929738	2010
The NIH Roadmap Epigenomics Mapping Consortium. Nature biotechnology\| PubMed ID: 20944595	2010
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nature genetics\| PubMed ID: 21057500	2010
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21098263	2010
High-quality draft assemblies of mammalian genomes from massively parallel sequence data. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21187386	2011
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21205891	2011
Integrative genomics viewer. Nature biotechnology\| PubMed ID: 21221095	2011
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell stem cell\| PubMed ID: 21295272	2011
Initial impact of the sequencing of the human genome. Nature\| PubMed ID: 21307931	2011
The genomic complexity of primary human prostate cancer. Nature\| PubMed ID: 21307934	2011
Genome-sequencing anniversary. The accelerator. Science (New York, N.Y.)\| PubMed ID: 21350161	2011
Initial genome sequencing and analysis of multiple myeloma. Nature\| PubMed ID: 21430775	2011
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS genetics\| PubMed ID: 21533027	2011
QnAs with Eric S. Lander. Interview by Prashant Nair. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21606349	2011
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746896	2011
The mutational landscape of head and neck squamous cell carcinoma. Science (New York, N.Y.)\| PubMed ID: 21798893	2011
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell\| PubMed ID: 21854987	2011
lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature\| PubMed ID: 21874018	2011
The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature\| PubMed ID: 21881562	2011
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature genetics\| PubMed ID: 21892161	2011
A high-resolution map of human evolutionary constraint using 29 mammals. Nature\| PubMed ID: 21993624	2011
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. The New England journal of medicine\| PubMed ID: 22150006	2011
Detecting novel associations in large data sets. Science (New York, N.Y.)\| PubMed ID: 22174245	2011
The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22223662	2012
Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22315421	2012