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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Article DOI: 10.3791/1869-v 22:27 min May 6th, 2010
May 6th, 2010



The Hi-C method allows unbiased, genome-wide identification of chromatin interactions (1). Hi-C couples proximity ligation and massively parallel sequencing. The resulting data can be used to study genomic architecture at multiple scales: initial results identified features such as chromosome territories, segregation of open and closed chromatin, and chromatin structure at the megabase scale.


Hi-C Three-dimensional Architecture Of Genomes Chromosome Folding Genome Activity Transcription Replication Microscopy Chromosomal Interactions Chromosome Conformation Capture (3C) Genome-wide Studies Hi-C Method DNA-protein Cross-links Biotinylated Residue Ligation Products
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