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JoVE Journal
Biology

This content is Open Access.

 

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Article doi: 10.3791/1869
May 6th, 2010

Summary May 6th, 2010

The Hi-C method allows unbiased, genome-wide identification of chromatin interactions (1). Hi-C couples proximity ligation and massively parallel sequencing. The resulting data can be used to study genomic architecture at multiple scales: initial results identified features such as chromosome territories, segregation of open and closed chromatin, and chromatin structure at the megabase scale.

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