Ottavio Arancio

Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University

Affiliated withColumbia University Columbia College

Research Area

Biography

Ottavio Arancio has not added Biography.
If you are Ottavio Arancio and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 74	2010

Other Publications

Article	Year
Calpain inhibitors: a treatment for Alzheimer's disease. Journal of molecular neuroscience : MN\| PubMed ID: 12212771	2002
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12244210	2002
Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease. Neurochemical research\| PubMed ID: 12737525	2003
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (New York, N.Y.)\| PubMed ID: 12907793	2003
Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. The EMBO journal\| PubMed ID: 12912911	2003
Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Journal of molecular neuroscience : MN\| PubMed ID: 14501020	2003
Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons. Neuron\| PubMed ID: 15066270	2004
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (New York, N.Y.)\| PubMed ID: 15087549	2004
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Annals of neurology\| PubMed ID: 15174014	2004
Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy. Journal of molecular neuroscience : MN\| PubMed ID: 15314245	2004
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. The American journal of pathology\| PubMed ID: 15331404	2004
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. The EMBO journal\| PubMed ID: 15457210	2004
alpha-Synuclein produces a long-lasting increase in neurotransmitter release. The EMBO journal\| PubMed ID: 15510220	2004
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. The Journal of clinical investigation\| PubMed ID: 15578094	2004
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15665036	2005
Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease. Current Alzheimer research\| PubMed ID: 15974910	2005
Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16033898	2005
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16399702	2006
BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nature neuroscience\| PubMed ID: 16819522	2006
Fibrillar beta-amyloid impairs the late phase of long term potentiation. Current Alzheimer research\| PubMed ID: 16842092	2006
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell\| PubMed ID: 16923396	2006
Early presynaptic changes during plasticity in cultured hippocampal neurons. The EMBO journal\| PubMed ID: 16957772	2006
Estimation of the mean from sums with unknown numbers of summands. Biometrics\| PubMed ID: 16984336	2006
Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease. Reviews in the neurosciences\| PubMed ID: 17180876	2006
Neurotrophins, synaptic plasticity and dementia. Current opinion in neurobiology\| PubMed ID: 17419049	2007
Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. The European journal of neuroscience\| PubMed ID: 17610578	2007
Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiology of aging\| PubMed ID: 17640772	2009
A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron\| PubMed ID: 18031684	2007
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18199809	2008
Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons. Current Alzheimer research\| PubMed ID: 18220514	2007
RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. Current molecular medicine\| PubMed ID: 18331231	2007
Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18367618	2008
Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Nature neuroscience\| PubMed ID: 18391946	2008
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18480253	2008
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiology of disease\| PubMed ID: 18504134	2008
Isolation and characterization of "Reprotoxin", a novel protein complex from Daboia russelii snake venom. Biochimie\| PubMed ID: 18573307	2008
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18591654	2008
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of clinical investigation\| PubMed ID: 18596919	2008
A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity. Channels (Austin, Tex.)\| PubMed ID: 18728399	2008
Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatric disease and treatment\| PubMed ID: 18728748	2008
Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. Journal of neurochemistry\| PubMed ID: 18796007	2008
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nature medicine\| PubMed ID: 18806802	2008
Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PloS one\| PubMed ID: 18978948	2008
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19118188	2008
Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE. Journal of Alzheimer's disease : JAD\| PubMed ID: 19221410	2009
Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini reviews in medicinal chemistry\| PubMed ID: 19356123	2009
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 19516252	2009
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19553447	2009
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 19625751	2009
Reversal of long-term dendritic spine alterations in Alzheimer disease models. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805389	2009
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. Expert review of neurotherapeutics\| PubMed ID: 19903023	2009
The ARMS/Kidins220 scaffold protein modulates synaptic transmission. Molecular and cellular neurosciences\| PubMed ID: 20547223	2010
PIP2: a new key player in Alzheimer's disease. Cellscience\| PubMed ID: 20577650	2008
Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20739563	2010
The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. The Journal of biological chemistry\| PubMed ID: 20943655	2010
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21048150	2010
Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21098268	2010
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21147981	2010
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's dise... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21307267	2011
A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Experimental neurology\| PubMed ID: 21419124	2011
Endogenous amyloid-Î² is necessary for hippocampal synaptic plasticity and memory. Annals of neurology\| PubMed ID: 21472769	2011
APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant. The EMBO journal\| PubMed ID: 21587206	2011
Î²- but not Î³-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. EMBO molecular medicine\| PubMed ID: 22170863	2011