Anthony J. Hannan

Florey Institute of Neuroscience and Mental Health, The University of Melbourne

Affiliated withThe University of Melbourne

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2015

Other Publications

Article	Year
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Annals of neurology\| PubMed ID: 11835380	2002
International Brain Research Organization--Sixth World Congress of Neuroscience. 10-15 July 2003, Prague, Czech Republic. IDrugs : the investigational drugs journal\| PubMed ID: 14565171	2003
Genetic and environmental factors in the pathogenesis of Huntington's disease. Neurogenetics\| PubMed ID: 14745585	2004
Society for neuroscience-33rd annual meeting. IDrugs : the investigational drugs journal\| PubMed ID: 14968806	2004
Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14999077	2004
Australian Neuroscience Society--24th annual meeting. 27-30 January 2004, Melbourne, Australia. IDrugs : the investigational drugs journal\| PubMed ID: 15017454	2004
Huntington's disease: which drugs might help patients? IDrugs : the investigational drugs journal\| PubMed ID: 15057641	2004
Decreased hippocampal cell proliferation in R6/1 Huntington's mice. Neuroreport\| PubMed ID: 15073520	2004
Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice. The European journal of neuroscience\| PubMed ID: 15147313	2004
Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease. Acta biochimica Polonica\| PubMed ID: 15218539	2004
Impaired learning-dependent cortical plasticity in Huntington's disease transgenic mice. Neurobiology of disease\| PubMed ID: 15571978	2004
Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 15749982	2005
Australian Neuroscience Society--25th Annual Meeting. 30 January-2 February 2005, Perth, Australia. IDrugs : the investigational drugs journal\| PubMed ID: 15772885	2005
Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15788762	2005
Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw. The FEBS journal\| PubMed ID: 15885086	2005
Novel therapeutic targets for Huntington's disease. Expert opinion on therapeutic targets\| PubMed ID: 16083335	2005
Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine. The European journal of neuroscience\| PubMed ID: 16262645	2005
Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease. Clinical and experimental pharmacology & physiology\| PubMed ID: 16445565	2005
Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment. The European journal of neuroscience\| PubMed ID: 16623840	2006
Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nature reviews. Neuroscience\| PubMed ID: 16924259	2006
European neuroscience - Federation of European Neuroscience Societies 5th Forum. 8-12 July 2006, Vienna, Austria. IDrugs : the investigational drugs journal\| PubMed ID: 17016767	2006
Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease. Journal of neurochemistry\| PubMed ID: 17217424	2007
Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients. Brain research\| PubMed ID: 17400200	2007
Regulators of adult neurogenesis in the healthy and diseased brain. Clinical and experimental pharmacology & physiology\| PubMed ID: 17439429	2007
Dynamic mutations as digital genetic modulators of brain development, function and dysfunction. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 17508392	2007
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type... Human molecular genetics\| PubMed ID: 17519223	2007
Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders. Expert opinion on therapeutic targets\| PubMed ID: 17614759	2007
International Brain Research Organization--Seventh World Congress of Neuroscience. 12-17 July 2007, Melbourne, Victoria, Australia. IDrugs : the investigational drugs journal\| PubMed ID: 17899483	2007
Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice. Neurobiology of disease\| PubMed ID: 18165017	2008
Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease. BMC neuroscience\| PubMed ID: 18380890	2008
Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington's disease. Brain research reviews\| PubMed ID: 18486229	2008
PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression. Hippocampus\| PubMed ID: 18493969	2008
Simple sequence repeats: genetic modulators of brain function and behavior. Trends in neurosciences\| PubMed ID: 18550185	2008
Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expression. The European journal of neuroscience\| PubMed ID: 18557922	2008
Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders. Neurobiology of disease\| PubMed ID: 18585920	2008
Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)\| PubMed ID: 18593507	2009
Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia. The Australian and New Zealand journal of psychiatry\| PubMed ID: 18622782	2008
Role of muscarinic receptors in the activity of N-desmethylclozapine: reversal of hyperactivity in the phospholipase C knockout mouse. Behavioural pharmacology\| PubMed ID: 18690108	2008
Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis. The European journal of neuroscience\| PubMed ID: 18702691	2008
European Neuroscience - Sixth Biennial FENS Forum. IDrugs : the investigational drugs journal\| PubMed ID: 18763213	2008
Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Human molecular genetics\| PubMed ID: 19008301	2009
Sensitivity to MK-801 in phospholipase C-β1 knockout mice reveals a specific NMDA receptor deficit. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)\| PubMed ID: 19236734	2009
Towards a therapy for Huntington's disease (Commentary on Giampà et al.). The European journal of neuroscience\| PubMed ID: 19291220	2009
Modeling brain reserve: experience-dependent neuronal plasticity in healthy and Huntington's disease transgenic mice. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry\| PubMed ID: 19454847	2009
The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders. Progress in neurobiology\| PubMed ID: 19819293	2009
Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for 'missing heritability'. Trends in genetics : TIG\| PubMed ID: 20036436	2010
Australian Neuroscience Society - 30th Annual Meeting and Australian Physiological Society - 50th Anniversary Meeting. IDrugs : the investigational drugs journal\| PubMed ID: 20373243	2010
Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease. Journal of neuropathology and experimental neurology\| PubMed ID: 20613636	2010
European Neuroscience--Seventh Biennial FENS Forum. IDrugs : the investigational drugs journal\| PubMed ID: 20799140	2010
Environmental enrichment: a cure for cancer? It's all in the mind. Journal of molecular cell biology\| PubMed ID: 20846952	2010
TRPing up the genome: Tandem repeat polymorphisms as dynamic sources of genetic variability in health and disease. Discovery medicine\| PubMed ID: 21034672	2010
Increased adult hippocampal neurogenesis and abnormal migration of adult-born granule neurons is associated with hippocampal-specific cognitive deficits in phospholipase C-β1 knockout mice. Hippocampus\| PubMed ID: 21080410	2012
Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness. The Australian and New Zealand journal of psychiatry\| PubMed ID: 21091263	2011
Mechanisms mediating brain and cognitive reserve: experience-dependent neuroprotection and functional compensation in animal models of neurodegenerative diseases. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 21112312	2011
Gene-environment interactions and construct validity in preclinical models of psychiatric disorders. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 21168465	2011
The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice. PloS one\| PubMed ID: 21455316	2011
Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise. British journal of pharmacology\| PubMed ID: 21718306	2012
Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PloS one\| PubMed ID: 21760962	2011
Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease. Neurobiology of disease\| PubMed ID: 22198376	2012
Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations. Neurobiology of disease\| PubMed ID: 22198572	2012
Behavioural state differentially engages septohippocampal cholinergic and GABAergic neurons in R6/1 Huntington's disease mice. Neurobiology of learning and memory\| PubMed ID: 22261461	2012
Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice. PLoS currents\| PubMed ID: 22266953	2011
Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice. Neurobiology of disease\| PubMed ID: 22426399	2012
Effects of environmental manipulations in genetically targeted animal models of affective disorders. Neurobiology of disease\| PubMed ID: 22525570	2013
Exploring the efficacy of constraint in animal models of stroke: meta-analysis and systematic review of the current evidence. Neurorehabilitation and neural repair\| PubMed ID: 22714123	2013
Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity. Neuropharmacology\| PubMed ID: 22766390	2013
Hippocampal neurogenesis, cognitive deficits and affective disorder in Huntington's disease. Neural plasticity\| PubMed ID: 22830053	2012
Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease. The Journal of physiology\| PubMed ID: 22890713	2012
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice. The Journal of physiology\| PubMed ID: 23045340	2013
The relationship between cortisol and verbal memory in the early stages of Huntington's disease. Journal of neurology\| PubMed ID: 23180175	2013
Nature, nurture and neurobiology: Gene-environment interactions in neuropsychiatric disorders. Neurobiology of disease\| PubMed ID: 23314279	2013
Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice. Molecular and cellular neurosciences\| PubMed ID: 23384443	2013
Depression-related behaviours displayed by female C57BL/6J mice during abstinence from chronic ethanol consumption are rescued by wheel-running. The European journal of neuroscience\| PubMed ID: 23551162	2013
Tandem repeat polymorphisms. Preface. Advances in experimental medicine and biology\| PubMed ID: 23560300	2012
Tandem repeat polymorphisms: Mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility. Advances in experimental medicine and biology\| PubMed ID: 23560301	2012
Towards environmental construct validity in animal models of CNS disorders: optimizing translation of preclinical studies. CNS & neurological disorders drug targets\| PubMed ID: 23574171	2013
Characterizing social behavior in genetically targeted mouse models of brain disorders. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23719910	2013
A Tale of Two Maladies? Pathogenesis of Depression with and without the Huntington's Disease Gene Mutation. Frontiers in neurology\| PubMed ID: 23847583	2013
Translating preclinical environmental enrichment studies for the treatment of autism and other brain disorders: comment on Woo and Leon (2013). Behavioral neuroscience\| PubMed ID: 23895065	2013
Positive environmental modification of depressive phenotype and abnormal hypothalamic-pituitary-adrenal axis activity in female C57BL/6J mice during abstinence from chronic ethanol consumpti... Frontiers in pharmacology\| PubMed ID: 23898297	2013
Short-term memory acquisition in female Huntington's disease mice is vulnerable to acute stress. Behavioural brain research\| PubMed ID: 23916759	2013
Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology\| PubMed ID: 23939410	2013
Epigenetic modifications in trinucleotide repeat diseases. Trends in molecular medicine\| PubMed ID: 23953480	2013
Cortisol and depression in pre-diagnosed and early stage Huntington's disease. Psychoneuroendocrinology\| PubMed ID: 24074804	2013
Decanalization mediating gene-environment interactions in schizophrenia and other psychiatric disorders with neurodevelopmental etiology. Frontiers in behavioral neuroscience\| PubMed ID: 24312026	2013
Beyond loss of frataxin: the complex molecular pathology of Friedreich ataxia. Discovery medicine\| PubMed ID: 24411698	2014
Noninvasive strategies to optimise brain plasticity: from basic research to clinical perspectives. Neural plasticity\| PubMed ID: 24490088	2013
Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain. Human molecular genetics\| PubMed ID: 24634145	2014
Vascular endothelial growth factor and brain-derived neurotrophic factor in quetiapine treated first-episode psychosis. Schizophrenia research and treatment\| PubMed ID: 24672724	2014
Novel ethological endophenotypes in a transgenic mouse model of Huntington's disease. Behavioural brain research\| PubMed ID: 24747660	2015
Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling. Hippocampus\| PubMed ID: 24802968	2014
High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice. Neurobiology of disease\| PubMed ID: 24825316	2014
Identifying novel interventional strategies for psychiatric disorders: integrating genomics, 'enviromics' and gene-environment interactions in valid preclinical models. British journal of pharmacology\| PubMed ID: 24846457	2014
Antidepressant-Like Effect of the Norepinephrine-Dopamine Reuptake Inhibitor Bupropion in a Mouse Model of Huntington's Disease with Dopaminergic Dysfunction. Journal of Huntington's disease\| PubMed ID: 25063334	2012
Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice. Neurobiology of disease\| PubMed ID: 25088714	2014
Ethological endophenotypes are altered by elevated stress hormone levels in both Huntington's disease and wildtype mice. Behavioural brain research\| PubMed ID: 25101541	2014
Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain. Biochimica et biophysica acta\| PubMed ID: 25159716	2014
'Super-Enrichment' Reveals Dose-Dependent Therapeutic Effects of Environmental Stimulation in a Transgenic Mouse Model of Huntington's Disease. Journal of Huntington's disease\| PubMed ID: 25300333	2014
Sexually dimorphic dopaminergic dysfunction in a transgenic mouse model of Huntington's disease. Pharmacology, biochemistry, and behavior\| PubMed ID: 25316307	2014
Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of Autism. Neuroscience letters\| PubMed ID: 25592157	2015