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Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
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JoVE Journal Neuroscience
Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

DOI:
10.3791/52329-v

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09:35 min

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January 20, 2015

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, , , , ,
1Florey Institute of Neuroscience and Mental Health,The University of Melbourne

Chapters

  • 00:05Title
  • 02:07Environmental Manipulations
  • 04:19Osmotic Pump and Brain Infusion Cannula Implants for Drug Infusion
  • 07:28Results: Representative Environmental Manipulation Effects on Substantia Nigra Pars Compacta (SNc) Tyrosine Hydroxylase Immunopositive (TH+) Neurons
  • 08:42Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes two different environmental manipulations and a concurrent brain infusion protocol to study environmentally-induced brain changes underlying adaptive behavior and brain repair in adult mice.

Tags

Keywords: MidbrainDopamine NeuronsEnvironmental ModulationBrain PlasticityTyrosine HydroxylaseEnriched EnvironmentSynaptic InputParkinson’s DiseaseADHDSchizophreniaDrug Addiction

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