Marcel Leist

Department of Biology, University of Konstanz

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 47	2015

Other Publications

Article	Year
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11971016	2002
Burning up TNF toxicity for cancer therapy. Nature medicine\| PubMed ID: 12091900	2002
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion. Cancer research\| PubMed ID: 12499245	2002
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression. Brain research\| PubMed ID: 12706247	2003
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12746497	2003
Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. Journal of neurochemistry\| PubMed ID: 14675162	2004
Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347. Journal of neurochemistry\| PubMed ID: 14720219	2004
Lysosomes in cell death. Oncogene\| PubMed ID: 15077151	2004
Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice. BMC neuroscience\| PubMed ID: 15134587	2004
Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science (New York, N.Y.)\| PubMed ID: 15247477	2004
Sensitization to the lysosomal cell death pathway upon immortalization and transformation. Cancer research\| PubMed ID: 15289336	2004
Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15294995	2004
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools. European journal of pharmacology\| PubMed ID: 15321729	2004
The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin. Journal of neurochemistry\| PubMed ID: 15525344	2004
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis. The Journal of cell biology\| PubMed ID: 15716378	2005
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. Journal of neurochemistry\| PubMed ID: 15748162	2005
CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice. European journal of pharmacology\| PubMed ID: 15904918	2005
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16000623	2005
The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function. Journal of neurochemistry\| PubMed ID: 16405499	2006
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. The European journal of neuroscience\| PubMed ID: 16420437	2006
A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption. Journal of neurochemistry\| PubMed ID: 16478524	2006
Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. The European journal of neuroscience\| PubMed ID: 16817864	2006
Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 16835629	2007
The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. Journal of neuroimmunology\| PubMed ID: 16996144	2006
[What can a chair on alternatives to animal experimentation effectuate?]. ALTEX\| PubMed ID: 17086353	2006
Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 17088947	2006
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippoc... Experimental neurology\| PubMed ID: 17157835	2007
Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation. Neuroreport\| PubMed ID: 17413657	2007
Wide spectrum modulation by KP-544 in models relevant for neuronal survival. Neuroreport\| PubMed ID: 17413659	2007
Pathological apoptosis in the developing brain. Apoptosis : an international journal on programmed cell death\| PubMed ID: 17453164	2007
Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor. Journal of neuroscience methods\| PubMed ID: 17524492	2007
The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells. The Journal of biological chemistry\| PubMed ID: 17804404	2007
Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels. Brain research\| PubMed ID: 18028884	2007
Molecular basis for detection of invading pathogens in the brain. Journal of neuroscience research\| PubMed ID: 18061944	2008
Food for thought... on the real success of 3R approaches. ALTEX\| PubMed ID: 18360724	2008
High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO). Thrombosis and haemostasis\| PubMed ID: 18392330	2008
Food for thought ... on the evolution of toxicology and the phasing out of animal testing. ALTEX\| PubMed ID: 18551232	2008
The dawning of a new age of toxicology. ALTEX\| PubMed ID: 18551234	2008
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX\| PubMed ID: 18841314	2008
Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems. Analytical biochemistry\| PubMed ID: 19454261	2009
The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. ALTEX\| PubMed ID: 19565166	2009
Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicology and applied pharmacology\| PubMed ID: 19647008	2009
The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening. Lab on a chip\| PubMed ID: 20221557	2010
Food for thought ... on education in alternative methods in toxicology. ALTEX\| PubMed ID: 20383471	2009
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX\| PubMed ID: 20390237	2010
The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology. ALTEX\| PubMed ID: 20390240	2010
Erythropoietin: not just about erythropoiesis. Lancet\| PubMed ID: 20609950	2010
Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20881186	2010
Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. The Journal of biological chemistry\| PubMed ID: 21081502	2011
Food for thought ... considerations and guidelines for basic test method descriptions in toxicology. ALTEX\| PubMed ID: 21240472	2010
TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21282508	2011
Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 21342877	2011
Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 21385734	2011
Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. Journal of neurochemistry\| PubMed ID: 21434924	2011
Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology\| PubMed ID: 22008243	2011
GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells. Glia\| PubMed ID: 22072312	2012
Critical evaluation of the use of dogs in biomedical research and testing in Europe. ALTEX\| PubMed ID: 22130483	2011
A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation. ALTEX\| PubMed ID: 22130484	2011
Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry. Chembiochem : a European journal of chemical biology\| PubMed ID: 22162214	2011
Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing. Archives of toxicology\| PubMed ID: 22187068	2012
Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology\| PubMed ID: 22206971	2012
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX\| PubMed ID: 22307314	2012
Locally resolved membrane binding affinity of the N-terminus of α-synuclein. Biochemistry\| PubMed ID: 22494024	2012
Control of Aβ release from human neurons by differentiation status and RET signaling. Neurobiology of aging\| PubMed ID: 22534065	2013
Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells. Environmental health perspectives\| PubMed ID: 22571897	2012
Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages. Antioxidants & redox signaling\| PubMed ID: 22578329	2012
Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment. PloS one\| PubMed ID: 22590590	2012
Compound selection for in vitro modeling of developmental neurotoxicity. Frontiers in bioscience (Landmark edition)\| PubMed ID: 22652791	2012
Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Human molecular genetics\| PubMed ID: 22723015	2012
Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions. ALTEX\| PubMed ID: 22847254	2012
Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods. ALTEX\| PubMed ID: 23138508	2012
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX\| PubMed ID: 23138511	2012
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Archives of toxicology\| PubMed ID: 23179753	2013
A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles. Archives of toxicology\| PubMed ID: 23203475	2013
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. Journal of neurochemistry\| PubMed ID: 23452040	2013
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Archives of toxicology\| PubMed ID: 23503654	2013
Metabolomics in toxicology and preclinical research. ALTEX\| PubMed ID: 23665807	2013
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. ALTEX\| PubMed ID: 23665808	2013
Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants. Archives of toxicology\| PubMed ID: 23670202	2013
Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing. Archives of toxicology\| PubMed ID: 23943209	2013
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. ALTEX\| PubMed ID: 24173167	2013
A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems. ALTEX\| PubMed ID: 24173170	2013
Test systems of developmental toxicity: state-of-the art and future perspectives. Archives of toxicology\| PubMed ID: 24190503	2013
Targeting chelatable iron as a therapeutic modality in Parkinson's disease. Antioxidants & redox signaling\| PubMed ID: 24251381	2014
Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chemical research in toxicology\| PubMed ID: 24383497	2014
Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development. Basic & clinical pharmacology & toxicology\| PubMed ID: 24476462	2014
Instruments for assessing risk of bias and other methodological criteria of animal studies: omission of well-established methods. Environmental health perspectives\| PubMed ID: 24583401	2014
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities. ALTEX\| PubMed ID: 24687333	2014
Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons. Neurotoxicology\| PubMed ID: 24726791	2014
Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 24845351	2014
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Archives of toxicology\| PubMed ID: 24935251	2014
Current approaches and future role of high content imaging in safety sciences and drug discovery. ALTEX\| PubMed ID: 25027442	2014
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX\| PubMed ID: 25027500	2014
Lineage-specific regulation of epigenetic modifier genes in human liver and brain. PloS one\| PubMed ID: 25054330	2014
Consensus report on the future of animal-free systemic toxicity testing. ALTEX\| PubMed ID: 25061899	2014
Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 25199799	2014
Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nature communications\| PubMed ID: 25208761	2014
Alpha-synuclein binds to the inner membrane of mitochondria in an α-helical conformation. Chembiochem : a European journal of chemical biology\| PubMed ID: 25209675	2014
Toxicogenomics directory of chemically exposed human hepatocytes. Archives of toxicology\| PubMed ID: 25399406	2014
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Archives of toxicology\| PubMed ID: 25618548	2015
Systems Toxicology: The Future of Risk Assessment. International journal of toxicology\| PubMed ID: 25804424	2015
From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data. Archives of toxicology\| PubMed ID: 25851820	2015
Prevention of human dopaminergic neurodegeneration in an astrocytes co-culture system allowing endogenous drug metabolism. British journal of pharmacology\| PubMed ID: 25989025	2015