Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Developmental Biology / Human Pluripotent Stem Cell Based Developmental…
JoVE Journal
Developmental Biology

A subscription to JoVE is required to view this content.

JoVE Journal Developmental Biology
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Electroporation of Primate Cerebral Organoids (Video) | JoVE
Journal (Developmental Biology)
Electroporation of Primate Cerebral Organoids (Video) | JoVE
Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
Journal (Developmental Biology)
Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
 

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Article DOI: 10.3791/52333-v • 17:28 min • June 17th, 2015
June 17th, 2015 •
*1, *2, 1, 1, 1, 3, 3, 4, 2, 1, *2, *1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
* These authors contributed equally

Chapters

Summary
Automatic Translation

The protocols describe two in vitro developmental toxicity test systems (UKK and UKN1) based on human embryonic stem cells and transcriptome studies. The test systems predict human developmental toxicity hazard, and may contribute to reduce animal studies, costs and the time required for chemical safety testing.

Tags

Human Pluripotent Stem Cells Developmental Toxicity Assays Chemical Safety Screening Systems Biology Data Generation In Vitro Toxicity Testing Potential Drugs Time Course Of Development Regulatory Mechanisms Systems Biology Approaches UKK Test System Human Embryonic Stem Cells (hESC) Embryoid Bodies Three Germ Layers Human-specific Early Embryonic Toxicity/teratogenicity UKN1 Test System Neuroectodermal Progenitor (NEP) Cells Early Neural Development Developmental Neurotoxicity Epigenetic Changes Transcriptome Microarray Studies Toxicity Biomarkers
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter