Jason S. Lewis

Department of Radiology, Memorial Sloan Kettering Cancer Center

Affiliated withMemorial Sloan Kettering Cancer Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2015
Publication title Cited by 81	2015

Other Publications

Article	Year
Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magn... Cancer research\| PubMed ID: 11809694	2002
Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 11935349	2002
DOTA-D-Tyr(1)-octreotate: a somatostatin analogue for labeling with metal and halogen radionuclides for cancer imaging and therapy. Bioconjugate chemistry\| PubMed ID: 12121126	2002
Small animal imaging. current technology and perspectives for oncological imaging. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 12387842	2002
Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone). Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 12411560	2002
Molecular imaging: the application of small animal positron emission tomography. Journal of cellular biochemistry. Supplement\| PubMed ID: 12552610	2002
Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report. International journal of radiation oncology, biology, physics\| PubMed ID: 12654432	2003
In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. European journal of nuclear medicine and molecular imaging\| PubMed ID: 12692685	2003
Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG. Nuclear medicine and biology\| PubMed ID: 12831991	2003
[Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? Against. European journal of nuclear medicine and molecular imaging\| PubMed ID: 12898205	2003
Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nuclear medicine and biology\| PubMed ID: 14499330	2003
Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose. Cancer research\| PubMed ID: 14500386	2003
Basic characterization of 64Cu-ATSM as a radiotherapy agent. Nuclear medicine and biology\| PubMed ID: 15691658	2005
Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents. Nuclear medicine and biology\| PubMed ID: 15721760	2005
Dosimetry of 60/61/62/64Cu-ATSM: a hypoxia imaging agent for PET. European journal of nuclear medicine and molecular imaging\| PubMed ID: 15785955	2005
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET ima... International journal of radiation oncology, biology, physics\| PubMed ID: 15817355	2005
Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH. Journal of medicinal chemistry\| PubMed ID: 15828837	2005
Positron-emitting isotopes produced on biomedical cyclotrons. Current medicinal chemistry\| PubMed ID: 15853713	2005
A tat fusion protein-based tumor vaccine for breast cancer. Annals of surgical oncology\| PubMed ID: 15889213	2005
Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM. Nuclear medicine and biology\| PubMed ID: 16026709	2005
Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer. Cancer research\| PubMed ID: 16166318	2005
Measurement of input functions in rodents: challenges and solutions. Nuclear medicine and biology\| PubMed ID: 16243642	2005
Preparation of high specific activity (86)Y using a small biomedical cyclotron. Nuclear medicine and biology\| PubMed ID: 16253815	2005
Minimally invasive method of determining blood input function from PET images in rodents. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 16455640	2006
Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 16513617	2006
In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna. Bone\| PubMed ID: 16533624	2006
Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides. Nuclear medicine and biology\| PubMed ID: 16546676	2006
Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 16595504	2006
Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide. Journal of medicinal chemistry\| PubMed ID: 16821789	2006
Imaging oxygenation of human tumours. European radiology\| PubMed ID: 17043737	2007
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. International journal of radiation biology\| PubMed ID: 17118889	2006
64Cu-azabicyclo[3.2.2]nonane thiosemicarbazone complexes: radiopharmaceuticals for PET of topoisomerase II expression in tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 17138747	2006
Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 17204700	2007
In vivo imaging in a murine model of glioblastoma. Neurosurgery\| PubMed ID: 17290188	2007
Molecular imaging of gastrin-releasing peptide receptor-positive tumors in mice using 64Cu- and 86Y-DOTA-(Pro1,Tyr4)-bombesin(1-14). Bioconjugate chemistry\| PubMed ID: 17378600	2007
Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 17992274	2007
Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma. Nuclear medicine and biology\| PubMed ID: 17998097	2007
Synthesis, in vitro and in vivo characterization of (64)Cu(I) complexes derived from hydrophilic tris(hydroxymethyl)phosphane and 1,3,5-triaza-7-phosphaadamantane ligands. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 18043951	2008
Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone). Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 18199612	2008
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 18199615	2008
Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines. Nuclear medicine and biology\| PubMed ID: 18355682	2008
In vitro and in vivo evaluation of bifunctional bisthiosemicarbazone 64Cu-complexes for the positron emission tomography imaging of hypoxia. Journal of medicinal chemistry\| PubMed ID: 18416544	2008
An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 18552145	2008
Radiometal-labeled somatostatin analogs for applications in cancer imaging and therapy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18604948	2007
Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies. Nuclear medicine and biology\| PubMed ID: 18678350	2008
Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer. Nuclear medicine and biology\| PubMed ID: 18678357	2008
Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pil... Diseases of the colon and rectum\| PubMed ID: 18682881	2008
Synthesis and characterization of the copper(II) complexes of new N2S2-donor macrocyclic ligands: synthesis and in vivo evaluation of the (64)Cu complexes. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 19081987	2009
In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 19223400	2009
Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution. Bioconjugate chemistry\| PubMed ID: 19260733	2009
(64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nuclear medicine and biology\| PubMed ID: 19324273	2009
Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 19380404	2009
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer research\| PubMed ID: 19417132	2009
Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH. Nuclear medicine and biology\| PubMed ID: 19423001	2009
Standardized methods for the production of high specific-activity zirconium-89. Nuclear medicine and biology\| PubMed ID: 19720285	2009
Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia. Journal of inorganic biochemistry\| PubMed ID: 19932509	2010
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. PloS one\| PubMed ID: 20111600	2010
Unconventional nuclides for radiopharmaceuticals. Molecular imaging\| PubMed ID: 20128994	2010
Clickable bifunctional radiometal chelates for peptide labeling. Chemical communications (Cambridge, England)\| PubMed ID: 20177623	2010
Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU). Nuclear medicine and biology\| PubMed ID: 20447555	2010
Cerenkov luminescence imaging of medical isotopes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 20554722	2010
89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 20660376	2010
Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes. International journal of nanomedicine\| PubMed ID: 21042424	2010
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes. Journal of medicinal chemistry\| PubMed ID: 21391686	2011
Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 21421727	2011
A practical guide to the construction of radiometallated bioconjugates for positron emission tomography. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 21442098	2011
Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions. Molecular imaging\| PubMed ID: 21496448	2011
The next generation of positron emission tomography radiopharmaceuticals in oncology. Seminars in nuclear medicine\| PubMed ID: 21624561	2011
The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in... Nuclear medicine and biology\| PubMed ID: 21718944	2011
Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry. Bioconjugate chemistry\| PubMed ID: 21877749	2011
Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 21908391	2011
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature chemical biology\| PubMed ID: 21946277	2011
89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging. Bioconjugate chemistry\| PubMed ID: 22035047	2011
Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen. Cancer discovery\| PubMed ID: 22576209	2012
Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjugate chemistry\| PubMed ID: 22784215	2012
An improved strategy for the synthesis of [¹⁸F]-labeled arabinofuranosyl nucleosides. Nuclear medicine and biology\| PubMed ID: 22819195	2012
PET imaging with ⁸⁹Zr: from radiochemistry to the clinic. Nuclear medicine and biology\| PubMed ID: 22998840	2013
Annotating MYC status with 89Zr-transferrin imaging. Nature medicine\| PubMed ID: 23001181	2012
H(2)azapa: a versatile acyclic multifunctional chelator for (67)Ga, (64)Cu, (111)In, and (177)Lu. Inorganic chemistry\| PubMed ID: 23106422	2012
(89)Zr-Labeled Paramagnetic Octreotide-Liposomes for PET-MR Imaging of Cancer. Pharmaceutical research\| PubMed ID: 23224977	2012
Imaging Tumor Burden in the Brain with 89Zr-Transferrin. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23236019	2013
Antilipolytic drug boosts glucose metabolism in prostate cancer. Nuclear medicine and biology\| PubMed ID: 23454248	2013
Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23578997	2013
The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23616581	2013
Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry. Bioconjugate chemistry\| PubMed ID: 23688208	2013
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23708196	2013
Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome. PloS one\| PubMed ID: 23741342	2013
Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin. Bioorganic & medicinal chemistry letters\| PubMed ID: 23796454	2013
H(4)octapa-trastuzumab: versatile acyclic chelate system for 111In and 177Lu imaging and therapy. Journal of the American Chemical Society\| PubMed ID: 23901833	2013
Feasibility and predictability of perioperative PET and estrogen receptor ligand in patients with invasive breast cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23970364	2013
Applying PET to broaden the diagnostic utility of the clinically validated CA19.9 serum biomarker for oncology. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 24029655	2013
H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 24104523	2014
A prospective pilot study of (89)zr-j591/prostate specific membrane antigen positron emission tomography in men with localized prostate cancer undergoing radical prostatectomy. The Journal of urology\| PubMed ID: 24135437	2014
Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter. European journal of nuclear medicine and molecular imaging\| PubMed ID: 24173571	2014
(18)F-labeled-bioorthogonal liposomes for in vivo targeting. Bioconjugate chemistry\| PubMed ID: 24180480	2013
Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals. Inorganic chemistry\| PubMed ID: 24313747	2014
Influence of free fatty acids on glucose uptake in prostate cancer cells. Nuclear medicine and biology\| PubMed ID: 24440212	2014
Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24573553	2014
Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and int... European journal of nuclear medicine and molecular imaging\| PubMed ID: 24604591	2014
Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer. Science signaling\| PubMed ID: 24667376	2014
Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives. Molecular pharmaceutics\| PubMed ID: 24779727	2014
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24785505	2014
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis. ChemistryOpen\| PubMed ID: 24808990	2014
Alternative chelator for ⁸⁹Zr radiopharmaceuticals: radiolabeling and evaluation of 3,4,3-(LI-1,2-HOPO). Journal of medicinal chemistry\| PubMed ID: 24814511	2014
In vivo imaging of GLP-1R with a targeted bimodal PET/fluorescence imaging agent. Bioconjugate chemistry\| PubMed ID: 24856928	2014
Development of a minimal saponin vaccine adjuvant based on QS-21. Nature chemistry\| PubMed ID: 24950335	2014
Targeting breast tumors with pH (low) insertion peptides. Molecular pharmaceutics\| PubMed ID: 25004202	2014
A modular labeling strategy for in vivo PET and near-infrared fluorescence imaging of nanoparticle tumor targeting. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 25060196	2014
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes & development\| PubMed ID: 25128497	2014
⁸⁹Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer. European journal of nuclear medicine and molecular imaging\| PubMed ID: 25143071	2014
What a difference a carbon makes: H₄octapa vs H₄C3octapa, ligands for In-111 and Lu-177 radiochemistry. Inorganic chemistry\| PubMed ID: 25192223	2014
Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression. European journal of medicinal chemistry\| PubMed ID: 25240701	2014
Chemoenzymatic strategy for the synthesis of site-specifically labeled immunoconjugates for multimodal PET and optical imaging. Bioconjugate chemistry\| PubMed ID: 25418333	2014
Annotating STEAP1 regulation in prostate cancer with 89Zr immuno-PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 25453051	2014