Keiji Itaka

Graduate School of Medicine, The University of Tokyo

Affiliated withThe University of Tokyo the university of tokyo

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2015

Other Publications

Article	Year
Recent development of nonviral gene delivery systems with virus-like structures and mechanisms. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18955136	2009
3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials\| PubMed ID: 19215979	2009
Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19337232	2009
Intranuclear fluorescence resonance energy transfer analysis of plasmid DNA decondensation from nonviral gene carriers. The journal of gene medicine\| PubMed ID: 19396931	2009
Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking. Molecular pharmaceutics\| PubMed ID: 19434856	2008
A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo. Cancer research\| PubMed ID: 19654315	2009
Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 20043959	2010
Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit. The Journal of biological chemistry\| PubMed ID: 20145241	2010
Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials\| PubMed ID: 20153891	2010
Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1. Molecular pharmaceutics\| PubMed ID: 20178335	2010
Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles. Angewandte Chemie (International ed. in English)\| PubMed ID: 20209539	2010
Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials\| PubMed ID: 20304483	2010
Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfectio... Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21571018	2011
Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. Journal of the American Chemical Society\| PubMed ID: 21879762	2011
Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles. Biomaterials\| PubMed ID: 21993237	2012
Progress and prospects of polyplex nanomicelles for plasmid DNA delivery. Current gene therapy\| PubMed ID: 22023475	2011
Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials\| PubMed ID: 22200535	2012
PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22334020	2012
Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials\| PubMed ID: 22444644	2012
Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22484197	2012
In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle. PloS one\| PubMed ID: 23418537	2013
Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice an... Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23422727	2013
Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nature communications\| PubMed ID: 23939267	2013
An injectable spheroid system with genetic modification for cell transplantation therapy. Biomaterials\| PubMed ID: 24388386	2014
Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials\| PubMed ID: 24439417	2014
Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24657809	2014
Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials\| PubMed ID: 24720877	2014
Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. Journal of the American Chemical Society\| PubMed ID: 25133991	2014
Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25449800	2015
Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25599855	2015
A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle. Soft matter\| PubMed ID: 25711768	2015
Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation. Drug delivery and translational research\| PubMed ID: 25787177	2012
Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity. Pharmaceutics\| PubMed ID: 26213960	2015