Ann F. Chambers

Oncology, Western University

Research Area

Biography

Ann F. Chambers has not added Biography.
If you are Ann F. Chambers and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2015

Other Publications

Article	Year
Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. Journal of cellular biochemistry\| PubMed ID: 11787071	2002
Activated ras regulates the proliferation/apoptosis balance and early survival of developing micrometastases. Cancer research\| PubMed ID: 11830548	2002
Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer research\| PubMed ID: 11929839	2002
Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. Journal of the National Cancer Institute\| PubMed ID: 11929952	2002
Dissemination and growth of cancer cells in metastatic sites. Nature reviews. Cancer\| PubMed ID: 12154349	2002
Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma. Cancer\| PubMed ID: 12209742	2002
Cancer spread and micrometastasis development: quantitative approaches for in vivo models. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 12325121	2002
Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways. Oncogene\| PubMed ID: 12606946	2003
Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter. Clinical & experimental metastasis\| PubMed ID: 12650610	2003
Osteopontin and colon cancer progression. Clinical & experimental metastasis\| PubMed ID: 12650611	2003
Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12847283	2003
Estrous cycle influences organ-specific metastasis of B16F10 melanoma cells. Cancer research\| PubMed ID: 12941790	2003
Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin. Molecular cancer research : MCR\| PubMed ID: 14517343	2003
The role of apoptosis in tumor progression and metastasis. Current molecular medicine\| PubMed ID: 14601637	2003
Evaluating the role of serine protease inhibition in the management of tumor micrometastases. Oncology (Williston Park, N.Y.)\| PubMed ID: 14606367	2003
Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast cancer research and treatment\| PubMed ID: 14703067	2003
Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14734468	2004
Osteopontin identified as colon cancer tumor progression marker. Comptes rendus biologies\| PubMed ID: 14744111	2003
Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis. Journal of clinical laboratory analysis\| PubMed ID: 15103681	2004
A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines. The Journal of nutrition\| PubMed ID: 15173424	2004
Mapping of the functional microcirculation in vital organs using contrast-enhanced in vivo video microscopy. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15388500	2005
In vivo videomicroscopy reveals differential effects of the vascular-targeting agent ZD6126 and the anti-angiogenic agent ZD6474 on vascular function in a liver metastasis model. Angiogenesis\| PubMed ID: 15516836	2004
Therapeutic targets for antimetastatic therapy. Expert opinion on therapeutic targets\| PubMed ID: 15584860	2004
Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 15810015	2005
Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model. Cancer research\| PubMed ID: 15833874	2005
Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression. Molecular carcinogenesis\| PubMed ID: 15864800	2005
Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver metastases in preclinical models. Cancer research\| PubMed ID: 15958568	2005
Re: Medroxyprogesterone acetate and metastases: of mice and (wo)men. Journal of the National Cancer Institute\| PubMed ID: 16106028	2005
Plasma osteopontin levels are predictive of disease stage in patients with transitional cell carcinoma of the bladder. BJU international\| PubMed ID: 16153205	2005
A new model for lymphatic metastasis: development of a variant of the MDA-MB-468 human breast cancer cell line that aggressively metastasizes to lymph nodes. Clinical & experimental metastasis\| PubMed ID: 16170671	2005
Expression of osteopontin and HGF/met in adult soft tissue tumors. Cancer biology & therapy\| PubMed ID: 16258259	2005
In vivo magnetic resonance imaging of single cells in mouse brain with optical validation. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 16342157	2006
Ovarian cancer biomarkers in urine. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16428467	2006
Time-course characterization of the computed tomography contrast enhancement of an iodinated blood-pool contrast agent in mice using a volumetric flat-panel equipped computed tomography scan... Investigative radiology\| PubMed ID: 16523021	2006
Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regul... Clinical & experimental metastasis\| PubMed ID: 16691370	2005
Serial plasma osteopontin levels have prognostic value in metastatic breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16740755	2006
Molecular mechanisms of metastasis. Cancer metastasis reviews\| PubMed ID: 16770533	2006
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy. The Journal of biological chemistry\| PubMed ID: 16807238	2006
Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer. The American journal of pathology\| PubMed ID: 16816376	2006
Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435. Clinical & experimental metastasis\| PubMed ID: 16830223	2006
Dormancy of solitary metastatic cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16861927	2006
Breast cancer metastasis progression as revealed by intravital videomicroscopy. Expert review of anticancer therapy\| PubMed ID: 17020460	2006
Tumor dormancy and the role of metastasis suppressor genes in regulating ectopic growth. Future oncology (London, England)\| PubMed ID: 17026454	2006
In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 17029229	2006
In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract. Nutrition and cancer\| PubMed ID: 17176222	2006
Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation. Molecular cancer\| PubMed ID: 17227585	2007
The biology of metastasis to a sanctuary site. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17363518	2007
Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis. Breast disease\| PubMed ID: 17473368	2006-2007
Brain metastases of breast cancer. Breast disease\| PubMed ID: 17473372	2006-2007
Tumour dormancy in breast cancer: an update. Breast cancer research : BCR\| PubMed ID: 17561992	2007
Osteopontin overexpression in breast cancer: knowledge gained and possible implications for clinical management. Journal of cellular biochemistry\| PubMed ID: 17721886	2007
Osteopontin expression in normal skin and non-melanoma skin tumors. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 17938278	2008
A new breast cancer model for lymphatic metastasis. Cancer treatment and research\| PubMed ID: 17953414	2007
Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17998900	2008
The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. Breast cancer research and treatment\| PubMed ID: 18097747	2008
Noninvasive quantification of tumor volume in preclinical liver metastasis models using contrast-enhanced x-ray computed tomography. Investigative radiology\| PubMed ID: 18197061	2008
Experimental metastasis assays in the chick embryo. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]\| PubMed ID: 18228449	2004
Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis. Cancer genetics and cytogenetics\| PubMed ID: 18262045	2008
Influence of diet on metastasis and tumor dormancy. Clinical & experimental metastasis\| PubMed ID: 18386136	2009
Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer. Breast cancer research and treatment\| PubMed ID: 18437556	2009
Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1. International journal of cancer. Journal international du cancer\| PubMed ID: 18470911	2008
BRMS1 suppresses breast cancer metastasis in multiple experimental models of metastasis by reducing solitary cell survival and inhibiting growth initiation. Clinical & experimental metastasis\| PubMed ID: 18543067	2008
Contrast-enhanced microcomputed tomography using intraperitoneal contrast injection for the assessment of tumor-burden in liver metastasis models. Investigative radiology\| PubMed ID: 18580331	2008
Ex-vivo cellular MRI with b-SSFP: quantitative benefits of 3T over 1.5 T. Magma (New York, N.Y.)\| PubMed ID: 18581153	2008
Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays. Breast cancer research : BCR\| PubMed ID: 18638373	2008
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer research\| PubMed ID: 18676848	2008
Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression. Cancer genetics and cytogenetics\| PubMed ID: 18786440	2008
New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target? APMIS : acta pathologica, microbiologica, et immunologica Scandinavica\| PubMed ID: 18834402	2008
Introduction to special issue on 'epigenetic and physiological regulation of metastasis'. Clinical & experimental metastasis\| PubMed ID: 18925360	2009
Chapter 9. Intravital videomicroscopy in angiogenesis research. Methods in enzymology\| PubMed ID: 19007666	2008
Effect of anti-fibrinolytic therapy on experimental melanoma metastasis. Clinical & experimental metastasis\| PubMed ID: 19082867	2009
Putative growth characteristics of micrometastatic breast cancer. Breast cancer research : BCR\| PubMed ID: 19090969	2008
New dual monoclonal ELISA for measuring plasma osteopontin as a biomarker associated with survival in prostate cancer: clinical validation and comparison of multiple ELISAs. Clinical chemistry\| PubMed ID: 19325010	2009
MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer research\| PubMed ID: 19549886	2009
Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and g... International journal of oncology\| PubMed ID: 19578743	2009
Tumor dormancy and metastasis. Advances in cancer research\| PubMed ID: 19595307	2009
Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches. Future oncology (London, England)\| PubMed ID: 19792975	2009
Three-dimensional imaging and quantification of both solitary cells and metastases in whole mouse liver by magnetic resonance imaging. Cancer research\| PubMed ID: 19843857	2009
Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number. PloS one\| PubMed ID: 20084286	2010
Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 20304630	2010
Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 20458274	2010
Role of the metastasis-promoting protein osteopontin in the tumour microenvironment. Journal of cellular and molecular medicine\| PubMed ID: 20597997	2010
Does tumour dormancy offer a therapeutic target? Nature reviews. Cancer\| PubMed ID: 21048784	2010
The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis. Clinical & experimental metastasis\| PubMed ID: 21234655	2011
Gene signatures of breast cancer progression and metastasis. Breast cancer research : BCR\| PubMed ID: 21345283	2011
Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21502940	2011
Pre- and post-translational regulation of osteopontin in cancer. Journal of cell communication and signaling\| PubMed ID: 21516514	2011
Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer. Molecular cancer research : MCR\| PubMed ID: 21665937	2011
In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 21698713	2011
In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach. Investigative radiology\| PubMed ID: 21788908	2011
Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models. Cancer biology & therapy\| PubMed ID: 21795853	2011
Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line. International journal of cancer. Journal international du cancer\| PubMed ID: 21823118	2012
Î²1-integrin: a potential therapeutic target in the battle against cancer recurrence. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21900388	2011
An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis (1) (1) This article is part of Special Issue entitled Asilomar Chromatin and h... Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 22047058	2011
Imaging the impact of chemically inducible proteins on cellular dynamics in vivo. PloS one\| PubMed ID: 22276156	2012
Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN. PloS one\| PubMed ID: 22545097	2012
Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22700400	2012
In Vivo Magnetic Resonance Imaging for Investigating the Development and Distribution of Experimental Brain Metastases due to Breast Cancer. Translational oncology\| PubMed ID: 22741041	2012
Brain metastases from breast cancer: lessons from experimental magnetic resonance imaging studies and clinical implications. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 24306136	2014
Hypoxia promotes tumor cell motility via RhoA and ROCK1 signaling pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24398519	2014
Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial. Breast cancer research : BCR\| PubMed ID: 24451146	2014
Radiation-induced lung injury after concurrent neoadjuvant chemoradiotherapy for locally advanced breast cancer. Acta oncologica (Stockholm, Sweden)\| PubMed ID: 24456500	2014
A method to validate quantitative high-frequency power doppler ultrasound with fluorescence in vivo video microscopy. Ultrasound in medicine & biology\| PubMed ID: 24798391	2014
Cyclin A2, a novel regulator of EMT. Cellular and molecular life sciences : CMLS\| PubMed ID: 24879294	2014
BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis. Molecular oncology\| PubMed ID: 24974076	2014
Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 25099519	2014
Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. Cell reports\| PubMed ID: 25176655	2014
Stage of breast cancer progression influences cellular response to activation of the WNT/planar cell polarity pathway. Scientific reports\| PubMed ID: 25204426	2014
An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25278743	2009
CORRIGENDUM: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway. Scientific reports\| PubMed ID: 25613050	2015