Here, real-time monitoring of tumor cell metabolism, combined with an in vivo chicken embryo chorio-allantoic membrane (CAM) model of metastasis, are used to evaluate novel anti-cancer targets/agents for their ability to sensitize tumor cells to DNA damaging chemotherapeutics.
Rytelewski, M., Buensuceso, A., Leong, H. S., Deroo, B. J., Chambers, A. F., Koropatnick, J. Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo. J. Vis. Exp. (96), e52388, doi:10.3791/52388 (2015).