Christopher J.H. Porter

Drug Delivery, Monash University (Parkville Campus)

Affiliated withMonash University (Parkville Campus)

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 48	2015

Other Publications

Article	Year
Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products. The Journal of pharmacy and pharmacology\| PubMed ID: 11833493	2002
A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. Journal of pharmaceutical sciences\| PubMed ID: 11920750	2002
Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. Pharmaceutical research\| PubMed ID: 12403073	2002
Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-... Journal of pharmaceutical sciences\| PubMed ID: 12587125	2003
Desbutylhalofantrine: evaluation of QT prolongation and other cardiovascular effects after intravenous administration in vivo. Journal of cardiovascular pharmacology\| PubMed ID: 12605019	2003
An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-ba... AAPS pharmSci\| PubMed ID: 12646011	2002
A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12649363	2003
Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo? Biopharmaceutics & drug disposition\| PubMed ID: 12698498	2003
Using the polymer partitioning method to probe the thermodynamic activity of poorly water-soluble drugs solubilized in model lipid digestion products. Journal of pharmaceutical sciences\| PubMed ID: 12761815	2003
Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cann... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12807999	2003
Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12920171	2003
Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep. Pharmaceutical research\| PubMed ID: 12948012	2003
Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) contai... European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 13678797	2003
Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs. Pharmaceutical research\| PubMed ID: 14567642	2003
Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach. Journal of pharmaceutical sciences\| PubMed ID: 14705191	2004
Pharmacokinetics of recombinant human leukemia inhibitory factor in sheep. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 14872093	2004
Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetized rabbit model. The Journal of pharmacy and pharmacology\| PubMed ID: 14980003	2004
Influence of physicochemical properties on the patterns of association of a series of aliphatic esters of halofantrine with plasma lipoproteins. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 14980776	2004
Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations. Pharmaceutical research\| PubMed ID: 15032305	2004
Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids. Pharmaceutical research\| PubMed ID: 15032306	2004
Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine. Journal of pharmaceutical sciences\| PubMed ID: 15067688	2004
Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation. Pharmaceutical research\| PubMed ID: 15359575	2004
A novel cubic phase of medium chain lipid origin for the delivery of poorly water soluble drugs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15380632	2004
Lymphatic absorption is the primary contributor to the systemic availability of epoetin Alfa following subcutaneous administration to sheep. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15579493	2005
Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug. Journal of pharmaceutical sciences\| PubMed ID: 15619248	2005
The interaction of lipophilic drugs with intestinal fatty acid-binding protein. The Journal of biological chemistry\| PubMed ID: 15722357	2005
An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli. Protein expression and purification\| PubMed ID: 15914028	2005
Bile increases intestinal lymphatic drug transport in the fasted rat. Pharmaceutical research\| PubMed ID: 16132351	2005
Tissue uptake of DDT is independent of chylomicron metabolism. Archives of toxicology\| PubMed ID: 16180009	2006
The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16249368	2006
An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 16467133	2006
Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone. The Journal of pharmacy and pharmacology\| PubMed ID: 16734982	2006
An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats. Pharmaceutical research\| PubMed ID: 16858652	2006
Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach. Journal of pharmaceutical sciences\| PubMed ID: 16883557	2006
The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep. Pharmaceutical research\| PubMed ID: 16951999	2006
Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats. Molecular pharmaceutics\| PubMed ID: 17009860	2006
Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach. Journal of pharmaceutical sciences\| PubMed ID: 17051595	2007
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nature reviews. Drug discovery\| PubMed ID: 17330072	2007
Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. Pharmaceutical research\| PubMed ID: 17372700	2007
Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Chemistry & biology\| PubMed ID: 17462580	2007
A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats. International journal of pharmaceutics\| PubMed ID: 17467935	2007
Use of plasma proteins as solubilizing agents in in vitro permeability experiments: correction for unbound drug concentration using the reciprocal permeability approach. Journal of pharmaceutical sciences\| PubMed ID: 17585392	2008
Low dose lipid formulations: effects on gastric emptying and biliary secretion. Pharmaceutical research\| PubMed ID: 17657595	2007
Lymphatic absorption of subcutaneously administered proteins: influence of different injection sites on the absorption of darbepoetin alfa using a sheep model. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 17875672	2007
Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition. Molecular pharmaceutics\| PubMed ID: 17953445	2007
Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. Journal of pharmaceutical sciences\| PubMed ID: 18064698	2008
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Advanced drug delivery reviews\| PubMed ID: 18068260	2008
Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Advanced drug delivery reviews\| PubMed ID: 18155316	2008
Enhancing intestinal drug solubilisation using lipid-based delivery systems. Advanced drug delivery reviews\| PubMed ID: 18155801	2008
Lipid-based systems for the enhanced delivery of poorly water soluble drugs. Advanced drug delivery reviews\| PubMed ID: 18160174	2008
The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly l-lysine dendrimers. Molecular pharmaceutics\| PubMed ID: 18393438	2008
Characterization of the drug binding specificity of rat liver fatty acid binding protein. Journal of medicinal chemistry\| PubMed ID: 18533710	2008
An evaluation of the relative roles of the unstirred water layer and receptor sink in limiting the in-vitro intestinal permeability of drug compounds of varying lipophilicity. The Journal of pharmacy and pharmacology\| PubMed ID: 18812024	2008
Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein. Molecular and cellular biochemistry\| PubMed ID: 19160019	2009
Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism. Pharmaceutical research\| PubMed ID: 19280324	2009
Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-l-lysine dendrimers. Molecular pharmaceutics\| PubMed ID: 19453158	2009
Oral bioavailability assessment and intestinal lymphatic transport of Org 45697 and Org 46035, two highly lipophilic novel immunomodulator analogues. Current drug delivery\| PubMed ID: 19534711	2009
Probing the fibrate binding specificity of rat liver fatty acid binding protein. Journal of medicinal chemistry\| PubMed ID: 19663428	2009
Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administrat... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19696095	2009
The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623). Pharmaceutical research\| PubMed ID: 20221896	2010
The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles. Pharmaceutical research\| PubMed ID: 20635194	2010
Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relev... The Journal of pharmacy and pharmacology\| PubMed ID: 20636872	2010
Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water-soluble drugs II. In-vivo evaluation. The Journal of pharmacy and pharmacology\| PubMed ID: 20636873	2010
Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation? Molecular pharmaceutics\| PubMed ID: 20958081	2010
Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility. Journal of drug targeting\| PubMed ID: 20973755	2010
Capping methotrexate Î±-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers. Molecular pharmaceutics\| PubMed ID: 21171585	2011
Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21301109	2011
Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21315119	2011
Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21497623	2011
Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte? Pharmaceutical research\| PubMed ID: 21523511	2011
Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption. Molecular pharmaceutics\| PubMed ID: 21604764	2011
Targeting the lymphatics using dendritic polymers (dendrimers). Advanced drug delivery reviews\| PubMed ID: 21683746	2011
A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 21704192	2012
Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance. Journal of pharmaceutical sciences\| PubMed ID: 21721002	2011
Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties. Nanomedicine (London, England)\| PubMed ID: 21955077	2011
Correction to "targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?". Molecular pharmaceutics\| PubMed ID: 21995681	2011
Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor... Molecular pharmaceutics\| PubMed ID: 22233281	2012
Association of Chemotherapeutic Drugs with Dendrimer Nanocarriers: An Assessment of the Merits of Covalent Conjugation Compared to Noncovalent Encapsulation. Molecular pharmaceutics\| PubMed ID: 22250750	2012
Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies. Journal of pharmaceutical sciences\| PubMed ID: 22623170	2012
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of represen... Journal of pharmaceutical sciences\| PubMed ID: 22644939	2012
Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems. Molecular pharmaceutics\| PubMed ID: 22656917	2012
Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrie... Molecular pharmaceutics\| PubMed ID: 22870936	2012
Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, ... Molecular pharmaceutics\| PubMed ID: 23030411	2012
In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization... International journal of pharmaceutics\| PubMed ID: 23178598	2013
The effect of administered dose of lipid-based formulations on the in vitro and in vivo performance of cinnarizine as a model poorly water-soluble drug. Journal of pharmaceutical sciences\| PubMed ID: 23242691	2013
Silica-lipid hybrid (SLH) formulations enhance the oral bioavailability and efficacy of celecoxib: An in vivo evaluation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23353808	2013
Strategies to address low drug solubility in discovery and development. Pharmacological reviews\| PubMed ID: 23383426	2013
A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport. Pharmaceutical research\| PubMed ID: 23430484	2013
Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation. Molecular pharmaceutics\| PubMed ID: 23480483	2013
PEGylation of interferon Î±2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23499718	2013
Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis. Molecular pharmaceutics\| PubMed ID: 23631696	2013
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of ty... Pharmaceutical research\| PubMed ID: 23661145	2013
In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the inte... European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 23684915	2013
The impact of lymphatic transport on the systemic disposition of lipophilic drugs. Journal of pharmaceutical sciences\| PubMed ID: 23696002	2013
The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs. Molecular pharmaceutics\| PubMed ID: 23697606	2013
A simple quantitative approach for the determination of long and medium chain lipids in bio-relevant matrices by high performance liquid chromatography with refractive index detection. AAPS PharmSciTech\| PubMed ID: 23733513	2013
Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent. Molecular pharmaceutics\| PubMed ID: 23750747	2013
Computational prediction of drug solubility in lipid based formulation excipients. Pharmaceutical research\| PubMed ID: 23771564	2013
Lipid absorption triggers drug supersaturation at the intestinal unstirred water layer and promotes drug absorption from mixed micelles. Pharmaceutical research\| PubMed ID: 23793990	2013
Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway. Pharmaceutical research\| PubMed ID: 23824582	2013
Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections. Antimicrobial agents and chemotherapy\| PubMed ID: 23917323	2013
PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23954628	2013
Gastric pre-processing is an important determinant of the ability of medium-chain lipid solution formulations to enhance oral bioavailability in rats. Journal of pharmaceutical sciences\| PubMed ID: 23983139	2013
Recent advances in lipid-based formulation technology. Pharmaceutical research\| PubMed ID: 24158727	2013
The lymphatic system plays a major role in the intravenous and subcutaneous pharmacokinetics of trastuzumab in rats. Molecular pharmaceutics\| PubMed ID: 24350780	2014
Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility. Chemical communications (Cambridge, England)\| PubMed ID: 24394756	2014
Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24398334	2014
Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of d... Journal of pharmaceutical sciences\| PubMed ID: 24470073	2014
Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation dig... Pharmaceutical research\| PubMed ID: 24477676	2014
Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration. Antimicrobial agents and chemotherapy\| PubMed ID: 24550334	2014
Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24637466	2014
Lipid-based formulations solidified via adsorption onto the mesoporous carrier Neusilin® US2: effect of drug type and formulation composition on in vitro pharmaceutical performance. Journal of pharmaceutical sciences\| PubMed ID: 24740767	2014
Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24801249	2014
The influence of intestinal lymphatic transport on the systemic exposure and brain deposition of a novel highly lipophilic compound with structural similarity to cholesterol. The Journal of pharmacy and pharmacology\| PubMed ID: 24821499	2014
Subcutaneous drug delivery and the role of the lymphatics. Drug discovery today. Technologies\| PubMed ID: 24981760	2005
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system. Journal of pharmaceutical sciences\| PubMed ID: 24985238	2014
Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components. Molecular pharmaceutics\| PubMed ID: 24987935	2014
'Stealth' lipid-based formulations: Poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25058571	2014
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein. ACS chemical biology\| PubMed ID: 25144524	2014
In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 25152213	2014
An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formu... Molecular pharmaceutics\| PubMed ID: 25265395	2014
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels. The AAPS journal\| PubMed ID: 25274609	2014
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase. Pharmaceutical research\| PubMed ID: 25288015	2014
Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug. Pharmaceutical research\| PubMed ID: 25446770	2014
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats. Molecular pharmaceutics\| PubMed ID: 25485615	2014
Optimal PEGylation can Improve the Exposure of Interferon in the Lungs Following Pulmonary Administration. Journal of pharmaceutical sciences\| PubMed ID: 25631360	2015
Size and rigidity of cylindrical polymer brushes dictate long circulating properties in vivo. ACS nano\| PubMed ID: 25634484	2015
PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneo... Molecular pharmaceutics\| PubMed ID: 25644368	2015