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JoVE Journal
Immunology and Infection

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The Mesenteric Lymph Duct Cannulated Rat Model

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Article DOI: 10.3791/52389
March 6th, 2015


Summary March 6th, 2015

Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.

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