David Shima

Ocular Biology and Therapeutics, University College London Institute of Ophthalmology

Affiliated withUniversity College London Institute of Ophthalmology Hoffman-La Roche

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2015

Other Publications

Article	Year
Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. The Journal of cell biology\| PubMed ID: 12070132	2002
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. The EMBO journal\| PubMed ID: 12234928	2002
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes & development\| PubMed ID: 12381667	2002
Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science (New York, N.Y.)\| PubMed ID: 12730604	2003
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. The Journal of cell biology\| PubMed ID: 12810700	2003
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. The Journal of experimental medicine\| PubMed ID: 12900522	2003
VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Investigative ophthalmology & visual science\| PubMed ID: 14744874	2004
Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15376331	2004
Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes & development\| PubMed ID: 15545635	2004
The role of vascular endothelial growth factor in ocular health and disease. Retina (Philadelphia, Pa.)\| PubMed ID: 15689799	2005
VEGF function in vascular pathogenesis. Experimental cell research\| PubMed ID: 16330026	2006
A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16357200	2005
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nature reviews. Drug discovery\| PubMed ID: 16518379	2006
Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. The American journal of pathology\| PubMed ID: 16723717	2006
Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Molecular vision\| PubMed ID: 16735995	2006
An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17075074	2006
Inhibitory effect of an antibody to cryptic collagen type IV epitopes on choroidal neovascularization. Molecular vision\| PubMed ID: 17110907	2006
Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Investigative ophthalmology & visual science\| PubMed ID: 17325165	2007
Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration. Investigative ophthalmology & visual science\| PubMed ID: 17389510	2007
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. The American journal of pathology\| PubMed ID: 17591953	2007
Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. The Journal of biological chemistry\| PubMed ID: 17626017	2007
RGS5 expression is a quantitative measure of pericyte coverage of blood vessels. Angiogenesis\| PubMed ID: 18038251	2008
Simultaneous but not prior inhibition of VEGF165 enhances the efficacy of photodynamic therapy in multiple models of ocular neovascularization. Investigative ophthalmology & visual science\| PubMed ID: 18235012	2008
Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors. Cancer research\| PubMed ID: 18381437	2008
Delta-like 4 is indispensable in thymic environment specific for T cell development. The Journal of experimental medicine\| PubMed ID: 18824583	2008
The heparin-binding domain confers diverse functions of VEGF-A in development and disease: a structure-function study. Biochemical Society transactions\| PubMed ID: 19909247	2009
Delivery of anti-angiogenic molecular therapies for retinal disease. Drug discovery today\| PubMed ID: 20184967	2010
Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22323600	2012
Do anti-angiogenic VEGF (VEGFxxxb) isoforms exist? A cautionary tale. PloS one\| PubMed ID: 22567098	2012
Assessing a novel depot delivery strategy for noninvasive administration of VEGF/PDGF RTK inhibitors for ocular neovascular disease. Investigative ophthalmology & visual science\| PubMed ID: 23385800	2013
VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. The American journal of pathology\| PubMed ID: 23416159	2013
A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. PloS one\| PubMed ID: 23840644	2013
Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction. Investigative ophthalmology & visual science\| PubMed ID: 24845632	2014
Differential apicobasal VEGF signaling at vascular blood-neural barriers. Developmental cell\| PubMed ID: 25175707	2014