Rick Maizels

Institute of Immunology and Infection Research, University of Edinburgh

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 105	2015

Other Publications

Article	Year
Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide seque... Molecular and biochemical parasitology\| PubMed ID: 12106871	2002
Molecular helminthology: an integrated approach. The American journal of tropical medicine and hygiene\| PubMed ID: 12164287	2002
Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure. The Journal of biological chemistry\| PubMed ID: 12221083	2002
Abundant larval transcript-1 and -2 genes from Brugia malayi: diversity of genomic environments but conservation of 5' promoter sequences functional in Caenorhabditis elegans. Molecular and biochemical parasitology\| PubMed ID: 12467974	2002
Immune regulation by helminth parasites: cellular and molecular mechanisms. Nature reviews. Immunology\| PubMed ID: 12949497	2003
Regulation of allergy and autoimmunity in helminth infection. Clinical reviews in allergy & immunology\| PubMed ID: 14755074	2004
Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. The Biochemical journal\| PubMed ID: 15142032	2004
Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites. Genome biology\| PubMed ID: 15186490	2004
Linked thioredoxin-glutathione systems in platyhelminths. Trends in parasitology\| PubMed ID: 15193566	2004
Resistance to helminth infection: the case for interleukin-5-dependent mechanisms. The Journal of infectious diseases\| PubMed ID: 15243913	2004
Lymphatic filariasis and Brugia timori: prospects for elimination. Trends in parasitology\| PubMed ID: 15246315	2004
Helminth parasites--masters of regulation. Immunological reviews\| PubMed ID: 15361235	2004
Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses. European journal of immunology\| PubMed ID: 15468056	2004
Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors. Immunology letters\| PubMed ID: 15585312	2005
Comparison of IgG-ELISA and IgG4-ELISA for Toxocara serodiagnosis. Acta tropica\| PubMed ID: 15589798	2005
Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infection and immunity\| PubMed ID: 15618176	2005
Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Molecular and biochemical parasitology\| PubMed ID: 15664654	2005
Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function. BMC biology\| PubMed ID: 15788098	2005
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15814720	2005
Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. The Journal of infectious diseases\| PubMed ID: 16107967	2005
Infections and allergy - helminths, hygiene and host immune regulation. Current opinion in immunology\| PubMed ID: 16202576	2005
Regulatory T cells induced by parasites and the modulation of allergic responses. Chemical immunology and allergy\| PubMed ID: 16210910	2006
Suppression of allergic airway inflammation by helminth-induced regulatory T cells. The Journal of experimental medicine\| PubMed ID: 16275759	2005
A new C-type lectin similar to the human immunoreceptor DC-SIGN mediates symbiont acquisition by a marine nematode. Applied and environmental microbiology\| PubMed ID: 16598002	2006
Molecular and cellular biology of helminth parasites IV. International journal for parasitology\| PubMed ID: 16620824	2006
F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16709852	2006
Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden. BMC infectious diseases\| PubMed ID: 16764709	2006
IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance. International immunology\| PubMed ID: 16940042	2006
O-methylated glycans from Toxocara are specific targets for antibody binding in human and animal infections. International journal for parasitology\| PubMed ID: 17087964	2007
Regulation of the immune system in metazoan parasite infections. Novartis Foundation symposium\| PubMed ID: 17534075	2007
Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection. European journal of immunology\| PubMed ID: 17563918	2007
CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17878360	2007
Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age. BMC infectious diseases\| PubMed ID: 18045464	2007
Alarming dendritic cells for Th2 induction. The Journal of experimental medicine\| PubMed ID: 18195077	2008
Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. The international journal of biochemistry & cell biology\| PubMed ID: 18249028	2008
The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products. Molecular and biochemical parasitology\| PubMed ID: 18439691	2008
Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population. The Journal of infectious diseases\| PubMed ID: 18549316	2008
Four abundant novel transcript genes from Toxocara canis with unrelated coding sequences share untranslated region tracts implicated in the control of gene expression. Molecular and biochemical parasitology\| PubMed ID: 18703093	2008
T-cell regulation in helminth parasite infections: implications for inflammatory diseases. Chemical immunology and allergy\| PubMed ID: 18802342	2008
Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941236	2008
Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection. European journal of immunology\| PubMed ID: 19089814	2009
MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages. Journal of leukocyte biology\| PubMed ID: 19179453	2009
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19234175	2009
How common is human toxocariasis? Towards standardizing our knowledge. Trends in parasitology\| PubMed ID: 19269251	2009
Generating EST libraries: trans-spliced cDNAs. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19277559	2009
Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage. Nature immunology\| PubMed ID: 25326751	2014
Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Molecular and biochemical parasitology\| PubMed ID: 19406170	2009
Parasite immunomodulation and polymorphisms of the immune system. Journal of biology\| PubMed ID: 19664200	2009
C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Parasitology international\| PubMed ID: 19751847	2009
A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk. PloS one\| PubMed ID: 19759914	2009
Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection. Immunology letters\| PubMed ID: 19766674	2009
Regulation of pathogenesis and immunity in helminth infections. The Journal of experimental medicine\| PubMed ID: 19770272	2009
Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum. European journal of immunology\| PubMed ID: 20063313	2010
Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. European journal of immunology\| PubMed ID: 20306466	2010
CD11c depletion severely disrupts Th2 induction and development in vivo. The Journal of experimental medicine\| PubMed ID: 20819926	2010
Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms. Journal of cell science\| PubMed ID: 20826456	2010
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. The Journal of experimental medicine\| PubMed ID: 20876311	2010
Heligmosomoides polygyrus: one species still. Trends in parasitology\| PubMed ID: 21159557	2011
Regulatory and activated T cells in human Schistosoma haematobium infections. PloS one\| PubMed ID: 21347311	2011
Defeating sepsis by misleading MyD88. Nature immunology\| PubMed ID: 21423223	2011
Immunology. Eosinophils forestall obesity. Science (New York, N.Y.)\| PubMed ID: 21474746	2011
Schistosome infection intensity is inversely related to auto-reactive antibody levels. PloS one\| PubMed ID: 21573157	2011
Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21576507	2011
Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor. Chemistry & biology\| PubMed ID: 21609838	2011
Diversity and dialogue in immunity to helminths. Nature reviews. Immunology\| PubMed ID: 21610741	2011
Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21705620	2011
Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins. Journal of proteomics\| PubMed ID: 21722761	2011
Addendum: Defeating sepsis by misleading MyD88. Nature immunology\| PubMed ID: 21772287	2011
Immune modulation and modulators in Heligmosomoides polygyrus infection. Experimental parasitology\| PubMed ID: 21875581	2012
Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21964031	2011
Wild immunology: converging on the real world. Annals of the New York Academy of Sciences\| PubMed ID: 22032399	2011
Regulatory T cells in infection. Advances in immunology\| PubMed ID: 22118407	2011
T cells in helminth infection: the regulators and the regulated. Trends in immunology\| PubMed ID: 22398370	2012
Forum: Immunology: Allergy challenged. Nature\| PubMed ID: 22538601	2012
Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics. PLoS neglected tropical diseases\| PubMed ID: 22666510	2012
Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. European journal of immunology\| PubMed ID: 22706967	2012
Cutting edge: in the absence of TGF-β signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-γ production renders mice more susceptible to helminth infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22753928	2012
Prevention of birch pollen-related food allergy by mucosal treatment with multi-allergen-chimers in mice. PloS one\| PubMed ID: 22768077	2012
Susceptibility and immunity to helminth parasites. Current opinion in immunology\| PubMed ID: 22795966	2012
Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion. Infection and immunity\| PubMed ID: 22851746	2012
Antibodies and IL-3 support helminth-induced basophil expansion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22930820	2012
Helminth infections and host immune regulation. Clinical microbiology reviews\| PubMed ID: 23034321	2012
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus. Seminars in immunopathology\| PubMed ID: 23053394	2012
A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation. PLoS neglected tropical diseases\| PubMed ID: 23209850	2012
Immunomodulation by helminth parasites: defining mechanisms and mediators. International journal for parasitology\| PubMed ID: 23291463	2013
ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. European journal of immunology\| PubMed ID: 23319295	2013
Toxocara canis: molecular basis of immune recognition and evasion. Veterinary parasitology\| PubMed ID: 23351972	2013
Gain of function in the immune system caused by a ryanodine receptor 1 mutation. Journal of cell science\| PubMed ID: 23704352	2013
Oesophagostomum dentatum extract modulates T cell-dependent immune responses to bystander antigens and prevents the development of allergy in mice. PloS one\| PubMed ID: 23844022	2013
Into the wild: digging at immunology's evolutionary roots. Nature immunology\| PubMed ID: 23959175	2013
Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity. PLoS pathogens\| PubMed ID: 23966853	2013
Helminths and immunological tolerance. Transplantation\| PubMed ID: 24025322	2014
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. The Journal of experimental medicine\| PubMed ID: 24101381	2013
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo. European journal of immunology\| PubMed ID: 24185641	2014
Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunology and cell biology\| PubMed ID: 24492801	2014
The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. PLoS pathogens\| PubMed ID: 24586152	2014
Vaccination against helminth parasite infections. Expert review of vaccines\| PubMed ID: 24606541	2014
Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi Infections: a study in Indonesian transmigrants. Parasites & vectors\| PubMed ID: 24685183	2014
Inflammatory Bowel Disease. Evolution, medicine, and public health\| PubMed ID: 24747119	2014
Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis. Molecular & cellular proteomics : MCP\| PubMed ID: 24994561	2014
Immunology. How helminths go viral. Science (New York, N.Y.)\| PubMed ID: 25082688	2014
MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25114104	2014
Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites. Gut microbes\| PubMed ID: 25144609	2014
MHC-II: a mutual support system for ILCs and T cells? Immunity\| PubMed ID: 25148019	2014
Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. Nature communications\| PubMed ID: 25421927	2014
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature communications\| PubMed ID: 25575242	2015
Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection. Frontiers in immunology\| PubMed ID: 25691884	2015
Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell acti... Experimental parasitology\| PubMed ID: 25728231	2015
Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immu... PLoS pathogens\| PubMed ID: 25816012	2015