Joseph A. Trapani

Joseph A. Trapani

Cancer Immunology Program, Peter MacCallum Cancer Centre

Affiliated withPeter MacCallum Cancer Centre

Research Area

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JoVE Journal Publications

ArticleTotal : 1
Year
A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
Publication title

Cited by 12

2014

Other Publications

Article
Year
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.

Immunity| PubMed ID: 11911826

2002
2002
Suppression of lymphoma and epithelial malignancies effected by interferon gamma.

The Journal of experimental medicine| PubMed ID: 12093877

2002
2002
Functional significance of the perforin/granzyme cell death pathway.

Nature reviews. Immunology| PubMed ID: 12360212

2002
2002
2002
2003
Expression of IFI 16 in epithelial cells and lymphoid tissues.

Histochemistry and cell biology| PubMed ID: 12548405

2003
2003
2003
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 12847210

2003
2003
Granzyme B: pro-apoptotic, antiviral and antitumor functions.

Current opinion in immunology| PubMed ID: 14499262

2003
2003
2004
Granzyme M mediates a novel form of perforin-dependent cell death.

The Journal of biological chemistry| PubMed ID: 15028722

2004
2004
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.

The Journal of biological chemistry| PubMed ID: 15069086

2004
Assaying cytochrome C translocation during apoptosis.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 15173625

2004
Cytotoxic activity of the lymphocyte toxin granzyme B.

Microbes and infection / Institut Pasteur| PubMed ID: 15207822

2004
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 15265951

2004
Cytotoxic lymphocytes; instigators of dramatic target cell death.

Biochemical pharmacology| PubMed ID: 15313398

2004
2004
A central role for Bid in granzyme B-induced apoptosis.

The Journal of biological chemistry| PubMed ID: 15574417

2005
2005
2005
2005
2005
2005
2005
2005
2005
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 16365285

2005
2006
Addressing the mysteries of perforin function.

Immunology and cell biology| PubMed ID: 16405653

2006
2006
2006
2006
2006
2006
2006
2006
2007
2006
Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17116876

2006
Perforin-mediated target-cell death and immune homeostasis.

Nature reviews. Immunology| PubMed ID: 17124515

2006
2007
Apoptosis induced by the lymphocyte effector molecule perforin.

Current opinion in immunology| PubMed ID: 17442557

2007
The complex issue of regulating perforin expression.

Trends in immunology| PubMed ID: 17466595

2007
2007
2007
Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans.

Advances in experimental medicine and biology| PubMed ID: 17713010

2007
A common fold mediates vertebrate defense and bacterial attack.

Science (New York, N.Y.)| PubMed ID: 17717151

2007
2007
Cloning and characterisation of Ifi206: a new murine HIN-200 family member.

Journal of cellular biochemistry| PubMed ID: 17786933

2008
2007
2008
The role of p202 in regulating hematopoietic cell proliferation and differentiation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research| PubMed ID: 18370867

2008
The MACPF/CDC family of pore-forming toxins.

Cellular microbiology| PubMed ID: 18564372

2008
2008
2008
2008
Perforin-mediated suppression of B-cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19196996

2009
2009
2009
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19487666

2009
2009
Proteolytic activation of the cytotoxic phenotype during human NK cell development.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 19570824

2009
The battlefield of perforin/granzyme cell death pathways.

Journal of leukocyte biology| PubMed ID: 19915166

2010
Endolysosomal proteases and their inhibitors in immunity.

Nature reviews. Immunology| PubMed ID: 19935806

2009
Incentives: encouraging adventurous ideas.

Science (New York, N.Y.)| PubMed ID: 20056875

2010
Cathepsin H is an additional convertase of pro-granzyme B.

The Journal of biological chemistry| PubMed ID: 20435891

2010
2010
2010
2010
2010
A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 20585036

2010
2010
2011
2011
2010
2010
2011
2011
2011
2011
2012
2012
Activated mouse B cells lack expression of granzyme B.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 22427643

2012
2012
2012
A novel role for granzymes in anti-tumor immunity.

Oncoimmunology| PubMed ID: 22720248

2012
2012
2013
2013
Cloning and characterising an unusual perforin from chicken (Gallus gallus).

Developmental and comparative immunology| PubMed ID: 23680640

2013
2013
Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 23831595

2013
Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 23885110

2013
2013
2013
2013
2014
The perforin pore facilitates the delivery of cationic cargos.

The Journal of biological chemistry| PubMed ID: 24558045

2014
Granzyme h is a novel protease expressed by human mast cells.

International archives of allergy and immunology| PubMed ID: 25342632

2014
A Method for Detecting Intracellular Perforin in Mouse Lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 25348626

2014
2014