Joseph A. Trapani

Cancer Immunology Program, Peter MacCallum Cancer Centre

Affiliated withPeter MacCallum Cancer Centre

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2014

Other Publications

Article	Year
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity\| PubMed ID: 11911826	2002
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells. Immunobiology\| PubMed ID: 11999346	2002
Suppression of lymphoma and epithelial malignancies effected by interferon gamma. The Journal of experimental medicine\| PubMed ID: 12093877	2002
Tumor-mediated apoptosis of cancer-specific T lymphocytes--reversing the "kiss of death"? Cancer cell\| PubMed ID: 12242147	2002
Functional significance of the perforin/granzyme cell death pathway. Nature reviews. Immunology\| PubMed ID: 12360212	2002
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood\| PubMed ID: 12384413	2002
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12421958	2002
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. The Journal of cell biology\| PubMed ID: 12538642	2003
Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochemistry and cell biology\| PubMed ID: 12548405	2003
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity\| PubMed ID: 12648450	2003
Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis. Journal of immunological methods\| PubMed ID: 12738359	2003
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12847210	2003
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer research\| PubMed ID: 12907619	2003
Granzyme B: pro-apoptotic, antiviral and antitumor functions. Current opinion in immunology\| PubMed ID: 14499262	2003
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene\| PubMed ID: 14681682	2003
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. The Journal of biological chemistry\| PubMed ID: 14752093	2004
Granzyme M mediates a novel form of perforin-dependent cell death. The Journal of biological chemistry\| PubMed ID: 15028722	2004
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer gene therapy\| PubMed ID: 15060573	2004
Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. The Journal of biological chemistry\| PubMed ID: 15069086	2004
Assaying cytochrome C translocation during apoptosis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15173625	2004
Cytotoxic activity of the lymphocyte toxin granzyme B. Microbes and infection / Institut Pasteur\| PubMed ID: 15207822	2004
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15265951	2004
Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochemical pharmacology\| PubMed ID: 15313398	2004
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. The Journal of experimental medicine\| PubMed ID: 15365097	2004
A central role for Bid in granzyme B-induced apoptosis. The Journal of biological chemistry\| PubMed ID: 15574417	2005
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. The Journal of biological chemistry\| PubMed ID: 15576364	2005
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochemical and biophysical research communications\| PubMed ID: 15582594	2005
A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood\| PubMed ID: 15755897	2005
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9. Journal of cellular biochemistry\| PubMed ID: 15791691	2005
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. The Journal of biological chemistry\| PubMed ID: 15843372	2005
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood\| PubMed ID: 16030195	2005
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Molecular and cellular biology\| PubMed ID: 16107729	2005
The dual adverse effects of TGF-beta secretion on tumor progression. Cancer cell\| PubMed ID: 16286241	2005
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16365285	2005
Report on apoptosis and immunity, 31 May-3 June 2005, Palm Cove, Queensland, Australia. Immunology and cell biology\| PubMed ID: 16405648	2006
Addressing the mysteries of perforin function. Immunology and cell biology\| PubMed ID: 16405653	2006
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunology and cell biology\| PubMed ID: 16405654	2006
A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation\| PubMed ID: 16436955	2006
Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL. International immunology\| PubMed ID: 16574667	2006
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. The Journal of cell biology\| PubMed ID: 16606695	2006
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes\| PubMed ID: 16873683	2006
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. The Journal of biological chemistry\| PubMed ID: 16914553	2006
Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes\| PubMed ID: 16936188	2006
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. The Journal of biological chemistry\| PubMed ID: 17105733	2007
The major human and mouse granzymes are structurally and functionally divergent. The Journal of cell biology\| PubMed ID: 17116752	2006
Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17116876	2006
Perforin-mediated target-cell death and immune homeostasis. Nature reviews. Immunology\| PubMed ID: 17124515	2006
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. The Journal of cell biology\| PubMed ID: 17283185	2007
Apoptosis induced by the lymphocyte effector molecule perforin. Current opinion in immunology\| PubMed ID: 17442557	2007
The complex issue of regulating perforin expression. Trends in immunology\| PubMed ID: 17466595	2007
Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function. Blood\| PubMed ID: 17475905	2007
The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue antigens\| PubMed ID: 17661907	2007
Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans. Advances in experimental medicine and biology\| PubMed ID: 17713010	2007
A common fold mediates vertebrate defense and bacterial attack. Science (New York, N.Y.)\| PubMed ID: 17717151	2007
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends in immunology\| PubMed ID: 17766182	2007
Cloning and characterisation of Ifi206: a new murine HIN-200 family member. Journal of cellular biochemistry\| PubMed ID: 17786933	2008
Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer research\| PubMed ID: 18056471	2007
Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules. Methods (San Diego, Calif.)\| PubMed ID: 18314055	2008
The role of p202 in regulating hematopoietic cell proliferation and differentiation. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 18370867	2008
The MACPF/CDC family of pore-forming toxins. Cellular microbiology\| PubMed ID: 18564372	2008
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral immunology\| PubMed ID: 18788942	2008
A renaissance in understanding the multiple and diverse functions of granzymes? Immunity\| PubMed ID: 19006688	2008
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. Journal of medicinal chemistry\| PubMed ID: 19007200	2008
Perforin-mediated suppression of B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19196996	2009
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 19242371	2009
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity\| PubMed ID: 19446473	2009
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19487666	2009
Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19525394	2009
Proteolytic activation of the cytotoxic phenotype during human NK cell development. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19570824	2009
The battlefield of perforin/granzyme cell death pathways. Journal of leukocyte biology\| PubMed ID: 19915166	2010
Endolysosomal proteases and their inhibitors in immunity. Nature reviews. Immunology\| PubMed ID: 19935806	2009
Incentives: encouraging adventurous ideas. Science (New York, N.Y.)\| PubMed ID: 20056875	2010
Cathepsin H is an additional convertase of pro-granzyme B. The Journal of biological chemistry\| PubMed ID: 20435891	2010
Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS biology\| PubMed ID: 20436908	2010
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology\| PubMed ID: 20497254	2010
Perforin: structure, function, and role in human immunopathology. Immunological reviews\| PubMed ID: 20536554	2010
Functional dissection of the granzyme family: cell death and inflammation. Immunological reviews\| PubMed ID: 20536556	2010
A role for granzyme M in TLR4-driven inflammation and endotoxicosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20585036	2010
Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining. Biological chemistry\| PubMed ID: 20731542	2010
Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function. Immunology and cell biology\| PubMed ID: 20975734	2011
The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood\| PubMed ID: 20978269	2011
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature\| PubMed ID: 21037563	2010
Tumor ablation by gene-modified T cells in the absence of autoimmunity. Cancer research\| PubMed ID: 21098715	2010
Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin. Immunology and cell biology\| PubMed ID: 21263463	2011
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity\| PubMed ID: 21658975	2011
Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles. Bioorganic & medicinal chemistry\| PubMed ID: 21664824	2011
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21709155	2011
Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin. Blood\| PubMed ID: 22186995	2012
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorganic & medicinal chemistry\| PubMed ID: 22244072	2012
Activated mouse B cells lack expression of granzyme B. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22427643	2012
Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC evolutionary biology\| PubMed ID: 22551122	2012
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends in immunology\| PubMed ID: 22608996	2012
A novel role for granzymes in anti-tumor immunity. Oncoimmunology\| PubMed ID: 22720248	2012
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. PloS one\| PubMed ID: 22792290	2012
Surprisingly variable "dangers, toils, and snares" faced by humans and mice. Blood\| PubMed ID: 23349371	2013
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood\| PubMed ID: 23377437	2013
Cloning and characterising an unusual perforin from chicken (Gallus gallus). Developmental and comparative immunology\| PubMed ID: 23680640	2013
Human perforin mutations and susceptibility to multiple primary cancers. Oncoimmunology\| PubMed ID: 23734337	2013
Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23831595	2013
Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23885110	2013
Defining the interaction of perforin with calcium and the phospholipid membrane. The Biochemical journal\| PubMed ID: 24070258	2013
Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. Journal of medicinal chemistry\| PubMed ID: 24195776	2013
Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function. Frontiers in immunology\| PubMed ID: 24376445	2013
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21. International immunology\| PubMed ID: 24497611	2014
The perforin pore facilitates the delivery of cationic cargos. The Journal of biological chemistry\| PubMed ID: 24558045	2014
Granzyme h is a novel protease expressed by human mast cells. International archives of allergy and immunology\| PubMed ID: 25342632	2014
A Method for Detecting Intracellular Perforin in Mouse Lymphocytes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25348626	2014
TRAIL(+) NK Cells Control CD4(+) T Cell Responses during Chronic Viral Infection to Limit Autoimmunity. Immunity\| PubMed ID: 25367576	2014