Paul D. W. Eckford

Programme in Molecular Structure and Function, Hospital for Sick Children

Affiliated withHospital for Sick Children

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2015

Other Publications

Article	Year
Reconstitution of membrane transporters. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12824648	2003
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids. The Biochemical journal\| PubMed ID: 15799713	2005
New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter. Journal of bioenergetics and biomembranes\| PubMed ID: 16691487	2005
P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 17215888	2006
Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. The Journal of biological chemistry\| PubMed ID: 18344567	2008
Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport. Biochemistry\| PubMed ID: 19049391	2008
ABC efflux pump-based resistance to chemotherapy drugs. Chemical reviews\| PubMed ID: 19583429	2009
The reconstituted Escherichia coli MsbA protein displays lipid flippase activity. The Biochemical journal\| PubMed ID: 20412049	2010
Targeting the regulation of CFTR channels. The Biochemical journal\| PubMed ID: 21726198	2011
Structural basis for alginate secretion across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21778407	2011
Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy. Essays in biochemistry\| PubMed ID: 21967060	2011
Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator. Journal of medicinal chemistry\| PubMed ID: 22074181	2011
Identification and validation of hits from high throughput screens for CFTR modulators. Current pharmaceutical design\| PubMed ID: 22229556	2012
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent m... The Journal of biological chemistry\| PubMed ID: 22942289	2012
Functional Rescue of F508del-CFTR Using Small Molecule Correctors. Frontiers in pharmacology\| PubMed ID: 23055971	2012
Proton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membrane. mBio\| PubMed ID: 24023388	2013
VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface. Chemistry & biology\| PubMed ID: 24726831	2014