Shaun R. Coughlin

Cardiovascular Research Institute, University of California

Affiliated withUniversity of California University of California, San Francisco

Research Area

Biography

Shaun R. Coughlin has not added Biography.
If you are Shaun R. Coughlin and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2015
Publication title Cited by 9	2015

Other Publications

Article	Year
Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. The Journal of biological chemistry\| PubMed ID: 11850418	2002
Protection against thrombosis in mice lacking PAR3. Blood\| PubMed ID: 12384423	2002
Overview of the Alliance for Cellular Signaling. Nature\| PubMed ID: 12478301	2002
PARticipation in inflammation. The Journal of clinical investigation\| PubMed ID: 12511583	2003
The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. The Journal of biological chemistry\| PubMed ID: 12773540	2003
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood\| PubMed ID: 12869501	2003
Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood\| PubMed ID: 14504091	2004
Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. The Journal of biological chemistry\| PubMed ID: 14982936	2004
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood\| PubMed ID: 15031212	2004
PAR1 cleavage and signaling in response to activated protein C and thrombin. The Journal of biological chemistry\| PubMed ID: 15665002	2005
Essential role for Galpha13 in endothelial cells during embryonic development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15919816	2005
Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16081834	2005
Roles of protease-activated receptors in a mouse model of endotoxemia. Blood\| PubMed ID: 16434493	2006
Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17190826	2007
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (New York, N.Y.)\| PubMed ID: 17363629	2007
Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. The Journal of experimental medicine\| PubMed ID: 17438064	2007
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology\| PubMed ID: 17570216	2007
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. The Journal of clinical investigation\| PubMed ID: 17992256	2007
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. The Journal of clinical investigation\| PubMed ID: 18292814	2008
Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood\| PubMed ID: 18490515	2008
Anatomical profiling of G protein-coupled receptor expression. Cell\| PubMed ID: 18984166	2008
Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development (Cambridge, England)\| PubMed ID: 19103804	2009
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. The Journal of clinical investigation\| PubMed ID: 19603543	2009
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. The Journal of experimental medicine\| PubMed ID: 20026661	2010
Local protease signaling contributes to neural tube closure in the mouse embryo. Developmental cell\| PubMed ID: 20152175	2010
Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation\| PubMed ID: 20351302	2010
Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20930120	2010
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nature communications\| PubMed ID: 21245842	2011
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nature immunology\| PubMed ID: 21642988	2011
Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood\| PubMed ID: 21860019	2011
Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22106277	2011
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell\| PubMed ID: 23021219	2012
PAR1 contributes to influenza A virus pathogenicity in mice. The Journal of clinical investigation\| PubMed ID: 23202729	2013
High-resolution crystal structure of human protease-activated receptor 1. Nature\| PubMed ID: 23222541	2012
IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. International immunology\| PubMed ID: 23657000	2013
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature\| PubMed ID: 23995678	2013
Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25278288	2014
Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25695968	2015