Friedrich Koch-Nolte

Institute of Immunology, University Medical Center, Hamburg

Affiliated withUniversity Medical Center, Hamburg

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 24	2015

Other Publications

Article	Year
Complex regulation of the human gene for the Z-DNA binding protein DLM-1. Nucleic acids research\| PubMed ID: 11842111	2002
Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. The Biochemical journal\| PubMed ID: 11879200	2002
The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Protein science : a publication of the Protein Society\| PubMed ID: 12070318	2002
Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2). Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 12077446	2002
Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus. Journal of molecular evolution\| PubMed ID: 12187378	2002
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat. Journal of molecular biology\| PubMed ID: 12270706	2002
Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Molecular and cellular biology\| PubMed ID: 12370300	2002
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12370338	2002
Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine. Analytical biochemistry\| PubMed ID: 12633608	2003
Analysis of subcellular calcium signals in T-lymphocytes. Cellular signalling\| PubMed ID: 12781871	2003
Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat. Biochemistry\| PubMed ID: 12939142	2003
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Immunity\| PubMed ID: 14563321	2003
Triggering of T-cell apoptosis by toxin-related ecto-ADP-ribosyltransferase ART2. Annals of the New York Academy of Sciences\| PubMed ID: 15033737	2003
T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells. Annals of the New York Academy of Sciences\| PubMed ID: 15033788	2003
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling. Current medicinal chemistry\| PubMed ID: 15078170	2004
T cells of different developmental stages differ in sensitivity to apoptosis induced by extracellular NAD. Developmental immunology\| PubMed ID: 15144016	2002
FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation\| PubMed ID: 15257041	2004
Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts. Blood\| PubMed ID: 15657180	2005
A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15659550	2005
CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15749861	2005
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. Endocrinology\| PubMed ID: 16037377	2005
Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization. Cellular immunology\| PubMed ID: 16165114	2005
A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens. Cellular immunology\| PubMed ID: 16168396	2005
Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats. Immunogenetics\| PubMed ID: 16195877	2005
In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs). BMC genomics\| PubMed ID: 16202152	2005
The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system. Transplant immunology\| PubMed ID: 16223672	2005
"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 16261419	2005
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation. Cellular immunology\| PubMed ID: 16271711	2005
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 16297791	2005
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16511307	2006
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 16573547	2006
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585549	2006
Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes. Asian journal of andrology\| PubMed ID: 16625277	2006
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells. Annals of medicine\| PubMed ID: 16720433	2006
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains. Nucleic acids research\| PubMed ID: 16990255	2006
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17015823	2006
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 17234520	2007
Emerging functions of extracellular pyridine nucleotides. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 17380199	2006
Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17575259	2007
NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17579037	2007
CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells. PloS one\| PubMed ID: 17710154	2007
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17928361	2008
Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17947697	2007
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Molecular and cellular biology\| PubMed ID: 17991898	2008
Structure of mouse ADP-ribosylhydrolase 3 (mARH3). Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 18323597	2008
Extracellular NAD and ATP: Partners in immune cell modulation. Purinergic signalling\| PubMed ID: 18404420	2007
Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation. Purinergic signalling\| PubMed ID: 18404449	2007
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 18508690	2008
High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18768840	2008
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Molecular and cellular biology\| PubMed ID: 19075008	2009
ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells. Journal of leukocyte biology\| PubMed ID: 19164130	2009
Emerging roles of NAD+ and its metabolites in cell signaling. Science signaling\| PubMed ID: 19211509	2009
NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19234185	2009
Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7. Purinergic signalling\| PubMed ID: 19234763	2009
Activation of the P2X7 ion channel by soluble and covalently bound ligands. Purinergic signalling\| PubMed ID: 19255877	2009
Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes. Purinergic signalling\| PubMed ID: 19404775	2009
Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19407395	2009
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity. Medical microbiology and immunology\| PubMed ID: 19529959	2009
Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19542469	2009
Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E). Cellular microbiology\| PubMed ID: 19552697	2009
A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. Journal of autoimmunity\| PubMed ID: 19796917	2010
Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends in biochemical sciences\| PubMed ID: 20106667	2010
Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells. Molecular imaging\| PubMed ID: 20643024	2010
ADP-ribosylation of arginine. Amino acids\| PubMed ID: 20652610	2011
Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20940265	2011
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. The Journal of experimental medicine\| PubMed ID: 20975043	2010
Compartmentation of NAD+-dependent signalling. FEBS letters\| PubMed ID: 21443875	2011
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. The Journal of biological chemistry\| PubMed ID: 21454673	2011
Progress in the function and regulation of ADP-Ribosylation. Science signaling\| PubMed ID: 21610250	2011
CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia. PloS one\| PubMed ID: 21625615	2011
Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death. Molecular immunology\| PubMed ID: 21641039	2011
Strategies for the identification of arginine ADP-ribosylation sites. Journal of proteomics\| PubMed ID: 21784185	2011
Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci. Hybridoma (2005)\| PubMed ID: 21851231	2011
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. FEBS letters\| PubMed ID: 21896273	2011
Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation. The Journal of biological chemistry\| PubMed ID: 22613720	2012
Extracellular NAD(+): a danger signal hindering regulatory T cells. Microbes and infection / Institut Pasteur\| PubMed ID: 22634347	2012
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation. PloS one\| PubMed ID: 22848454	2012
CD8-β ADP-ribosylation affects CD8(+) T-cell function. European journal of immunology\| PubMed ID: 23575529	2013
The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs. The FEBS journal\| PubMed ID: 23627412	2013
Physiology of ADP-ribosylation. The FEBS journal\| PubMed ID: 23773547	2013
CD38 controls the innate immune response against Listeria monocytogenes. Infection and immunity\| PubMed ID: 23980105	2013
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17. Biochimica et biophysica acta\| PubMed ID: 24135057	2013
Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells. Journal of leukocyte biology\| PubMed ID: 24212099	2014
Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB). Human mutation\| PubMed ID: 24375680	2014
Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. Cellular microbiology\| PubMed ID: 24444337	2014
Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24469807	2014
In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies. Contrast media & molecular imaging\| PubMed ID: 24523058	2014
ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells. Current topics in microbiology and immunology\| PubMed ID: 25048544	2015
ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses. Cellular and molecular life sciences : CMLS\| PubMed ID: 25292337	2015
Nanobodies as modulators of inflammation: potential applications for acute brain injury. Frontiers in cellular neuroscience\| PubMed ID: 25374510	2014
Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT. Scientific reports\| PubMed ID: 25597743	2015
The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation. Journal of autoimmunity\| PubMed ID: 25640206	2015
Tuning IL-2 signaling by ADP-ribosylation of CD25. Scientific reports\| PubMed ID: 25753532	2015