Willard M. Freeman

Department of Physiology, University of Oklahoma College of Medicine

Affiliated withUniversity of Oklahoma College of Medicine oklahoma medical research foundation Oklahoma City Veterans Affairs Medical Center

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 83	2015
Publication title Cited by 2	2023

Other Publications

Article	Year
Changes in rat frontal cortex gene expression following chronic cocaine. Brain research. Molecular brain research\| PubMed ID: 12117546	2002
Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. Neurochemical research\| PubMed ID: 12462416	2002
Systematic screening of gene expression using a cDNA macroarray. Methods in molecular medicine\| PubMed ID: 12506701	2003
Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity. Neurotoxicology\| PubMed ID: 12520757	2002
Use of microarray technologies in toxicology research. Neurotoxicology\| PubMed ID: 12782098	2003
An interactive database of cocaine-responsive gene expression. TheScientificWorldJournal\| PubMed ID: 12805995	2002
Functional genomic analysis in pain research using hybridization arrays. Methods in molecular medicine\| PubMed ID: 15131342	2004
Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats. Journal of neurochemistry\| PubMed ID: 15140200	2004
Proteomics for protein expression profiling in neuroscience. Neurochemical research\| PubMed ID: 15176464	2004
Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology\| PubMed ID: 15183009	2004
Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Journal of neuroscience research\| PubMed ID: 15846778	2005
Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration. Alcohol and alcoholism (Oxford, Oxfordshire)\| PubMed ID: 16581821	2006
Depletion of abundant proteins from non-human primate serum for biomarker studies. Proteomics\| PubMed ID: 16619306	2006
Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes\| PubMed ID: 16936187	2006
Plasma proteomics: a noninvasive window on pathology and pediatric cardiac surgery. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 16966860	2006
Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 17851536	2008
Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatric research\| PubMed ID: 18317239	2008
Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior. Pharmacology, biochemistry, and behavior\| PubMed ID: 18466961	2008
Twenty-five years of quantitative PCR for gene expression analysis. BioTechniques\| PubMed ID: 18474036	2008
Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC medical genomics\| PubMed ID: 18554398	2008
Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina. The European journal of neuroscience\| PubMed ID: 18662330	2008
Human embryonic and mesenchymal stem cells express different nuclear proteomes. Stem cells and development\| PubMed ID: 18821827	2009
Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18931054	2009
Correlating human and animal studies of cocaine abuse and gene expression. Annals of the New York Academy of Sciences\| PubMed ID: 18991951	2008
Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemico-biological interactions\| PubMed ID: 19038236	2009
The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin. Molecular & cellular proteomics : MCP\| PubMed ID: 19049959	2009
The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome. Proteome science\| PubMed ID: 19323824	2009
Pediatric cardiopulmonary bypass circuits: a review of studies conducted at the Penn State Pediatric Cardiac Research Laboratories. The Journal of extra-corporeal technology\| PubMed ID: 19361042	2009
FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK). Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 19380174	2010
Gene expression changes following extinction testing in a heroin behavioral incubation model. BMC neuroscience\| PubMed ID: 19664213	2009
The use of neuroproteomics in drug abuse research. Drug and alcohol dependence\| PubMed ID: 19926406	2010
Circulating cytokines as biomarkers of alcohol abuse and alcoholism. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20020329	2010
Transcriptomic comparison of the retina in two mouse models of diabetes. Journal of ocular biology, diseases, and informatics\| PubMed ID: 20157355	2009
Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration. Proteomics. Clinical applications\| PubMed ID: 20161123	2009
Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. BMC neuroscience\| PubMed ID: 20187946	2010
Classification of alcohol abuse by plasma protein biomarkers. Biological psychiatry\| PubMed ID: 20299005	2010
Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatric research\| PubMed ID: 20308938	2010
Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders. Alcoholism, clinical and experimental research\| PubMed ID: 20374220	2010
Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome. Journal of neurochemistry\| PubMed ID: 20374424	2010
Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury. Investigative ophthalmology & visual science\| PubMed ID: 20554620	2010
Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice. Proteome science\| PubMed ID: 20565803	2010
Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization. Proteome science\| PubMed ID: 21092202	2010
Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys. Alcoholism, clinical and experimental research\| PubMed ID: 21118275	2011
2-D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells. Proteomics. Clinical applications\| PubMed ID: 21136975	2009
Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. PloS one\| PubMed ID: 21249158	2011
TPH2 in the ventral tegmental area of the male rat brain. Brain research bulletin\| PubMed ID: 21272616	2011
Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)\| PubMed ID: 21303580	2011
Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiology of disease\| PubMed ID: 21440628	2011
Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. BMC medical genomics\| PubMed ID: 21575160	2011
Age-related alterations in retinal neurovascular and inflammatory transcripts. Molecular vision\| PubMed ID: 21633715	2011
The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions. Frontiers in aging neuroscience\| PubMed ID: 21647399	2011
Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. The Journal of endocrinology\| PubMed ID: 21750148	2011
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. Journal of neuroinflammation\| PubMed ID: 21989322	2011
A Longitudinal Analysis of Circulating Stress-Related Proteins and Chronic Ethanol Self-Administration in Cynomolgus Macaques. Alcoholism, clinical and experimental research\| PubMed ID: 22141444	2011
The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Artificial organs\| PubMed ID: 22250822	2012
Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. Journal of neurochemistry\| PubMed ID: 22269040	2012
Nanoliposomal minocycline for ocular drug delivery. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22465498	2013
Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. Journal of molecular neuroscience : MN\| PubMed ID: 22562814	2012
Quantification of Hepatic UDP glucuronosyltransferase 1A splice variant expression and correlation of UDP glucuronosyltransferase 1A1 variant expression with glucuronidation activity. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22661630	2012
Protein biomarkers of alcohol abuse. Expert review of proteomics\| PubMed ID: 22967079	2012
Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition. The European journal of neuroscience\| PubMed ID: 23438185	2013
Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. Cellular and molecular neurobiology\| PubMed ID: 23525710	2013
Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing. Epigenetics & chromatin\| PubMed ID: 24279302	2013
Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways. Journal of biomechanics\| PubMed ID: 24720889	2014
Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats. Experimental eye research\| PubMed ID: 24931083	2014
Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 24994846	2014
Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data. BMC bioinformatics\| PubMed ID: 26423047	2015
CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 26786204	2016
Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordrecht, Netherlands)\| PubMed ID: 27091453	2016
Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle. Age (Dordrecht, Netherlands)\| PubMed ID: 27444179	2016
Role of DNA methylation in the dietary restriction mediated cellular memory. GeroScience\| PubMed ID: 28477138	2017
Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy. Journal of neurochemistry\| PubMed ID: 28902411	2017
Sexually divergent DNA methylation patterns with hippocampal aging. Aging cell\| PubMed ID: 28948711	2017
Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Molecular metabolism\| PubMed ID: 29398615	2018
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic ... The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 29893815	2019
The role of DNA methylation in epigenetics of aging. Pharmacology & therapeutics\| PubMed ID: 30419258	2019
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 30706998	2019
Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 31074767	2020
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia. GeroScience\| PubMed ID: 32394347	2020
Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer. Scientific reports\| PubMed ID: 32457453	2020
Exercising your mind. Science (New York, N.Y.)\| PubMed ID: 32646988	2020
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. Neurobiology of aging\| PubMed ID: 32846275	2020
Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. International journal of oncology\| PubMed ID: 33174020	2020
Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Communications biology\| PubMed ID: 33214681	2020
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α. eLife\| PubMed ID: 33289482	2020
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion. Mechanisms of ageing and development\| PubMed ID: 33383072	2021
Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells. American journal of respiratory cell and molecular biology\| PubMed ID: 33444514	2021
Long-term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 34546662	2021
Litter expansion alters metabolic homeostasis in a sex specific manner. PloS one\| PubMed ID: 34587168	2021
Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function. GeroScience\| PubMed ID: 34606039	2021
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging. Aging cell\| PubMed ID: 34655509	2021
Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addiction biology\| PubMed ID: 34825430	2022
The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation. Cells\| PubMed ID: 34831437	2021
Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging cell\| PubMed ID: 35199907	2022
Minimizing the Confounds of Cell-Isolation Techniques on Transcriptomic and Translatomic Profiles of Purified Microglia. eNeuro\| PubMed ID: 35228310	2022
Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex. Molecular neurobiology\| PubMed ID: 35589920	2022
An RNA-seq study of the mPFC of rats with different addiction phenotypes. Brain research bulletin\| PubMed ID: 36223840	2022
Translatomic response of retinal Müller glia to acute and chronic stress. Neurobiology of disease\| PubMed ID: 36423879	2022
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 36516471	2023
Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36653629	2023
Chromosomal and gonadal factors regulate microglial sex effects in the aging brain. Brain research bulletin\| PubMed ID: 36804773	2023