Neil R. Cashman

Department of Neurology, University of British Columbia

Affiliated withUniversity of British Columbia

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2015

Other Publications

Article	Year
Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form. The Journal of biological chemistry\| PubMed ID: 12161431	2002
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. The Journal of biological chemistry\| PubMed ID: 12356748	2002
A letter from CMAJ's editorial board to the CMA. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 12451066	2002
Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. AJNR. American journal of neuroradiology\| PubMed ID: 12637300	2003
Induced adaptive resistance to oxidative stress in the CNS: a discussion on possible mechanisms and their therapeutic potential. Current drug metabolism\| PubMed ID: 12678694	2003
A prion protein epitope selective for the pathologically misfolded conformation. Nature medicine\| PubMed ID: 12778138	2003
Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 12861047	2003
Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. The Journal of biological chemistry\| PubMed ID: 14734542	2004
Prion diseases--close to effective therapy? Nature reviews. Drug discovery\| PubMed ID: 15459678	2004
Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis. Molecular & cellular proteomics : MCP\| PubMed ID: 15501831	2004
Post-poliomyelitis syndrome. Muscle & nerve\| PubMed ID: 15599928	2005
Progress in prion vaccines and immunotherapies. Expert opinion on biological therapy\| PubMed ID: 15709913	2005
Current and future molecular diagnostics for prion diseases. Expert review of molecular diagnostics\| PubMed ID: 16824033	2006
Decreased cell surface prion protein in mouse models of prion disease. Neuroreport\| PubMed ID: 17259851	2007
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nature medicine\| PubMed ID: 17486090	2007
Species barriers for chronic wasting disease by in vitro conversion of prion protein. Biochemical and biophysical research communications\| PubMed ID: 17964288	2007
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18296640	2008
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. PLoS genetics\| PubMed ID: 18802454	2008
Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding. Protein engineering, design & selection : PEDS\| PubMed ID: 19602568	2009
Prion protein expression and release by mast cells after activation. The Journal of infectious diseases\| PubMed ID: 19642931	2009
Design and delivery of a cryptic PrP(C) epitope for induction of PrP(Sc)-specific antibody responses. Vaccine\| PubMed ID: 19925901	2010
Electrostatics in the stability and misfolding of the prion protein: salt bridges, self energy, and solvation. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 20453937	2010
Immunotherapy for prion diseases: opportunities and obstacles. Immunotherapy\| PubMed ID: 20635933	2010
Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21041683	2010
Preface. Prion research in perspective. Journal of toxicology and environmental health. Part A\| PubMed ID: 21218335	2011
Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions. Journal of toxicology and environmental health. Part A\| PubMed ID: 21218344	2011
Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21283077	2011
A theory for the anisotropic and inhomogeneous dielectric properties of proteins. Physical chemistry chemical physics : PCCP\| PubMed ID: 21359369	2011
Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach. PloS one\| PubMed ID: 21448279	2011
An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21478263	2011
Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies. Biochemistry\| PubMed ID: 21800884	2011
The prion protein binds thiamine. The FEBS journal\| PubMed ID: 21848803	2011
Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide. Biochemical and biophysical research communications\| PubMed ID: 21871872	2011
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21930926	2011
Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study. BMC neurology\| PubMed ID: 22032272	2011
Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit. Journal of toxicology and environmental health. Part A\| PubMed ID: 22043906	2011
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis. PloS one\| PubMed ID: 22493728	2012
A special focus issue on the materials of Prion 2011 meeting in Montreal, Canada. Prion\| PubMed ID: 22634715	2012
Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics. PloS one\| PubMed ID: 23393562	2013
Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: potential implications for immunotherapy of familial prion diseases. Prion\| PubMed ID: 23787697	2013
PrP(Sc)-specific antibodies do not induce prion disease or misfolding of PrP(C) in highly susceptible Tga20 mice. Prion\| PubMed ID: 24105298	2013
The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24133259	2013
The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. The Journal of biological chemistry\| PubMed ID: 24225951	2013
Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis. Prion\| PubMed ID: 24394345	2014
Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes. Prion\| PubMed ID: 24401607	2013
Interpretation of cerebrospinal fluid protein tests in the diagnosis of sporadic Creutzfeldt-Jakob disease: an evidence-based approach. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 24446456	2014
Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes. Vaccine\| PubMed ID: 24486363	2014
Safety, specificity and immunogenicity of a PrP(Sc)-specific prion vaccine based on the YYR disease specific epitope. Prion\| PubMed ID: 24509522	2014
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24550511	2014
Update on the provisional estimation of developing iatrogenic variant Creutzfeldt-Jakob disease from human islet cell transplantation procedures. Transplantation\| PubMed ID: 24933255	2014
Intermediate CAG repeat expansion in the ATXN2 gene is a unique genetic risk factor for ALS--a systematic review and meta-analysis of observational studies. PloS one\| PubMed ID: 25148523	2014
A meta-analysis of observational studies of the association between chronic occupational exposure to lead and amyotrophic lateral sclerosis. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine\| PubMed ID: 25479292	2014
Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding. Prion\| PubMed ID: 25551548	2014
From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis. Neurobiology of disease\| PubMed ID: 25701498	2015