in-vivo-percutaneous-needle-based-optical-coherence-tomography-renal

<em>In Vivo</em>, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Optical coherence tomography (OCT) is the optical equivalent of ultrasound imaging, based on the backscattering of near infrared light. OCT provides real ...

Academic Medical Center

Focal therapy has gained attention in the treatment of small renal masses. However its use is encased by scarce data on long-term outcomes and low evidence regarding perioperative complications. Our purpose is to review the emerging data in the past 18 months.

Focal therapy in the management of small renal masses.

To evaluate the efficacy of the self-retaining barbed suture (SRBS) in renal defect repair during partial nephrectomy (PN), by assessing perioperative outcomes.

Partial nephrectomy: is there an advantage of the self-retaining barbed suture in the perioperative period? A matched case-control comparison.

To assess the use of prognostic factors and models in renal-cell carcinoma (RCC) and to gain insight in the motivations precluding prognosis estimation and the use of prognosticators.

Prognostic models and factors for patients with renal-cell carcinoma: a survey on their use among urologists.

Developments in optical diagnostics have potential for less invasive diagnosis of upper urinary tract urothelial carcinoma (UUT-UC). This systematic review provides an overview of technology, applications, and limitations of recently developed optical diagnostics in the upper urinary tract and outlines their potential for future clinical applications. In addition, current evidence was evaluated.

Optical diagnostics for upper urinary tract urothelial cancer: technology, thresholds, and clinical applications.

Ninety-five percent of all urothelial carcinomas are located in the bladder and 5% in the upper urinary tract. Therefore, upper urinary tract urothelial carcinoma is relatively rare, with an incidence of 2.1-2.4 per 100,000 persons per year. Diagnosis is based on imaging, endoscopy, urine cytology and histology. Histopathological diagnosis of upper urinary tract tumours is essential for choice of therapy and follow-up, as both tumour grade and stage are important prognostic factors. Radical nephroureterectomy is the standard treatment, but has a direct effect on kidney function. For this reason, an increasing number of patients with low-risk tumours undergo kidney-sparing surgery to maintain kidney function. After kidney-sparing surgery intensive follow-up of the ipsilateral upper urinary tract is mandatory because of a five-year recurrence-free survival rate of 17-63%, depending on tumour grade. Current diagnostics all have their limitations. Nowadays, research focuses on improving diagnosis in order to be able to offer better individual treatment.

[Urothelial carcinoma in the upper urinary tract: developments in diagnostics, treatment and follow-up].

Although tissue ablation by irreversible electroporation (IRE) has been characterized as nonthermal, the application of frequent repetitive high-intensity electric pulses has the potential of substantially heating the targeted tissue and causing thermal damage. This study evaluates the risk of possible thermal damage by measuring temperature development and distribution during IRE of porcine kidney tissue.

Article	Year
Focal therapy in the management of small renal masses. Current opinion in urology\| PubMed ID: 22773057	2012
Partial nephrectomy: is there an advantage of the self-retaining barbed suture in the perioperative period? A matched case-control comparison. World journal of urology\| PubMed ID: 22956042	2012
Prognostic models and factors for patients with renal-cell carcinoma: a survey on their use among urologists. Journal of endourology / Endourological Society\| PubMed ID: 23379666	2013
Optical diagnostics for upper urinary tract urothelial cancer: technology, thresholds, and clinical applications. Journal of endourology / Endourological Society\| PubMed ID: 25178057	2015
[Urothelial carcinoma in the upper urinary tract: developments in diagnostics, treatment and follow-up]. Nederlands tijdschrift voor geneeskunde\| PubMed ID: 25227883	2014
Irreversible electroporation of the porcine kidney: Temperature development and distribution. Urologic oncology\| PubMed ID: 25557146	2014

Patricia J. Zondervan

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