Bruno Kyewski

Division of Developmental Immunology, German Cancer Research Center (DKFZ)

Affiliated withGerman Cancer Research Center (DKFZ)

Research Area

Biography

Bruno Kyewski has not added Biography.
If you are Bruno Kyewski and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2015

Other Publications

Article	Year
Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends in immunology\| PubMed ID: 12103357	2002
Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes. The Journal of experimental medicine\| PubMed ID: 12566411	2003
Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nature medicine\| PubMed ID: 12910264	2003
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. The Journal of experimental medicine\| PubMed ID: 14734521	2004
CREB function is required for normal thymic cellularity and post-irradiation recovery. European journal of immunology\| PubMed ID: 15214044	2004
Self-representation in the thymus: an extended view. Nature reviews. Immunology\| PubMed ID: 15343368	2004
Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory. International journal of oncology\| PubMed ID: 15375534	2004
Regulating self-tolerance by deregulating gene expression. Current opinion in immunology\| PubMed ID: 15511667	2004
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. The Journal of experimental medicine\| PubMed ID: 15983066	2005
Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire. Cancer research\| PubMed ID: 16024649	2005
Linking signalling pathways, thymic stroma integrity and autoimmunity. Trends in immunology\| PubMed ID: 16039157	2005
Conflicts of interest: the responsibility of the authors and editors of the International Journal of Cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 16482565	2006
A central role for central tolerance. Annual review of immunology\| PubMed ID: 16551260	2006
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16709665	2006
Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues. Immunology letters\| PubMed ID: 16876259	2006
Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. European journal of immunology\| PubMed ID: 17323415	2007
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy. Cancer research\| PubMed ID: 17440107	2007
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature\| PubMed ID: 17687331	2007
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells. European journal of immunology\| PubMed ID: 18000951	2007
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18180458	2008
How promiscuity promotes tolerance: the case of myasthenia gravis. Annals of the New York Academy of Sciences\| PubMed ID: 18567865	2008
Immunology. A breath of Aire for the periphery. Science (New York, N.Y.)\| PubMed ID: 18687943	2008
The thymus medulla slowly yields its secrets. Annals of the New York Academy of Sciences\| PubMed ID: 19076347	2008
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. The Journal of experimental medicine\| PubMed ID: 19564355	2009
Obligation for cell line authentication: appeal for concerted action. International journal of cancer. Journal international du cancer\| PubMed ID: 19882693	2010
Antigen presentation in the thymus for positive selection and central tolerance induction. Nature reviews. Immunology\| PubMed ID: 19935803	2009
Aire, master of many trades. Cell\| PubMed ID: 20085700	2010
Chronic inflammation is regarded as a strong promoter of tumorigenesis. International journal of cancer. Journal international du cancer\| PubMed ID: 20564540	2010
How thymic antigen presenting cells sample the body's self-antigens. Current opinion in immunology\| PubMed ID: 20832274	2010
Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20966351	2010
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions. Blood\| PubMed ID: 21372153	2011
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. The Journal of clinical investigation\| PubMed ID: 21436590	2011
Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance. Human molecular genetics\| PubMed ID: 21642385	2011
DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Molecular immunology\| PubMed ID: 22036612	2011
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nature immunology\| PubMed ID: 22179202	2012
The classical dichotomy between presentation of endogenous antigens via the MHC class I pathway and exogenous antigens via the MHC class-II pathway. Current opinion in immunology\| PubMed ID: 22305303	2012
An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23269248	2013
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. European journal of immunology\| PubMed ID: 23589212	2013
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23980163	2013
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nature reviews. Immunology\| PubMed ID: 24830344	2014
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells. European journal of immunology\| PubMed ID: 24846220	2014
Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages. Immunity\| PubMed ID: 25148026	2014
Love is in the Aire: mTECs share their assets. Immunity\| PubMed ID: 25238088	2014
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25552543	2015
Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome. Journal of autoimmunity\| PubMed ID: 25911201	2015
Materno-fetal transfer of preproinsulin through the neonatal Fc receptor prevents autoimmune diabetes. Diabetes\| PubMed ID: 25918233	2015
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction. Immunity\| PubMed ID: 26070482	2015