Donald J. Buchsbaum

Radiation Oncology, University of Alabama at Birmingham

Affiliated withUniversity of Alabama at Birmingham

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2015

Other Publications

Article	Year
Model prediction of treatment planning for dose-fractionated radioimmunotherapy. Cancer\| PubMed ID: 11877755	2002
Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: a sensitive method for assessing 5-fluorocytosine toxicity in vitro. Analytical biochemistry\| PubMed ID: 11814289	2002
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. Cancer research\| PubMed ID: 11830532	2002
Targeted radiotherapy with [(90)Y]-SMT 487 in mice bearing human nonsmall cell lung tumor xenografts induced to express human somatostatin receptor subtype 2 with an adenoviral vector. Cancer\| PubMed ID: 11877760	2002
Rationales, evidence, and design considerations for fractionated radioimmunotherapy. Cancer\| PubMed ID: 11877764	2002
De novo synthesis of a new diethylenetriaminepentaacetic acid (DTPA) bifunctional chelating agent. Bioconjugate chemistry\| PubMed ID: 11906270	2002
Synthesis of the first diethylenetriaminepentahydroxamic acid (DTPH) bifunctional chelating agent. Bioconjugate chemistry\| PubMed ID: 11906271	2002
Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice. Radiology\| PubMed ID: 11997547	2002
Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12161185	2002
Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation. International journal of radiation oncology, biology, physics\| PubMed ID: 12419447	2002
Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiati... Molecular cancer therapeutics\| PubMed ID: 12481438	2002
An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma. International journal of radiation oncology, biology, physics\| PubMed ID: 12605984	2003
Invited commentary: targeting of 125I-labeled B lymphocyte stimulator. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 12621011	2003
Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery. Bioconjugate chemistry\| PubMed ID: 12643740	2003
Three-dimensional dose model for the comparison of 177Lu-HuCC49DeltaCH2 and 177Lu-HuCC49 radioimunotherapy in mice bearing intraperitoneal xenografts. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 12804050	2003
Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody. The Journal of surgical research\| PubMed ID: 12850474	2003
Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14506165	2003
Imaging and therapy of tumors induced to express somatostatin receptor by gene transfer using radiolabeled peptides and single chain antibody constructs. Seminars in nuclear medicine\| PubMed ID: 14735457	2004
Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells. International journal of radiation oncology, biology, physics\| PubMed ID: 14967455	2004
Anti-EGFR-mediated radiosensitization as a result of augmented EGFR expression. International journal of radiation oncology, biology, physics\| PubMed ID: 15142629	2004
Gene expression imaging with radiolabeled peptides. Annals of nuclear medicine\| PubMed ID: 15359919	2004
Site-specifically traced drug release and biodistribution of a paclitaxel-antibody conjugate toward improvement of the linker structure. Bioconjugate chemistry\| PubMed ID: 15546192	2004
Adenovirus-mediated FLT1-targeted proapoptotic gene therapy of human prostate cancer. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15564138	2004
Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract\| PubMed ID: 15585383	2004
Radiotargeted gene therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 15653667	2005
The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry\| PubMed ID: 15653686	2005
Intraperitoneal radioimmunotherapy with a humanized anti-TAG-72 (CC49) antibody with a deleted CH2 region. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 16248766	2005
Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. Gynecologic oncology\| PubMed ID: 16271751	2006
Intraperitoneal pretarget radioimmunotherapy with CC49 fusion protein. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16299250	2005
Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16361565	2005
Gene delivery and gene therapy of prostate cancer. Expert opinion on drug delivery\| PubMed ID: 16370939	2006
Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array: Application to hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma. The Journal of molecular diagnostics : JMD\| PubMed ID: 16436637	2006
TRAIL receptor-targeted therapy. Future oncology (London, England)\| PubMed ID: 16922616	2006
Pretargeted radioimmunotherapy. International journal of radiation oncology, biology, physics\| PubMed ID: 16979441	2006
Treatment with gemcitabine and TRA-8 anti-death receptor-5 mAb reduces pancreatic adenocarcinoma cell viability in vitro and growth in vivo. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract\| PubMed ID: 17114015	2006
Oncolytic HSV-1 for the treatment of brain tumours. Herpes : the journal of the IHMF\| PubMed ID: 17147910	2006
Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Gynecologic oncology\| PubMed ID: 17303227	2007
High-resolution single-photon emission computed tomography and X-ray computed tomography imaging of Tc-99m-labeled anti-DR5 antibody in breast tumor xenografts. Molecular cancer therapeutics\| PubMed ID: 17363481	2007
Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer. Surgery\| PubMed ID: 17383523	2007
Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response. Annals of surgical oncology\| PubMed ID: 17453292	2007
ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib. Cancer biology & therapy\| PubMed ID: 17457047	2007
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its therapeutic potential in breast and gynecologic cancers. Gynecologic oncology\| PubMed ID: 17602728	2007
TRAIL-receptor antibodies as a potential cancer treatment. Future oncology (London, England)\| PubMed ID: 17661715	2007
Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17875786	2007
Brief overview of preclinical and clinical studies in the development of intraperitoneal radioimmunotherapy for ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17875801	2007
EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients. The Journal of surgical research\| PubMed ID: 17950068	2007
TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth. Molecular cancer therapeutics\| PubMed ID: 18089714	2007
Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model. Gynecologic oncology\| PubMed ID: 18177927	2008
Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18381960	2008
Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5. International journal of radiation oncology, biology, physics\| PubMed ID: 18474311	2008
Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects. Vaccine\| PubMed ID: 18598733	2008
Molecular targeted therapies for pancreatic cancer. American journal of surgery\| PubMed ID: 18718222	2008
Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene. Molecular cancer therapeutics\| PubMed ID: 18790765	2008
Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging. Cancer research\| PubMed ID: 18922909	2008
In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts. ORL; journal for oto-rhino-laryngology and its related specialties\| PubMed ID: 18931526	2009
Preclinical studies and clinical utilization of monoclonal antibodies in epithelial ovarian cancer. Gynecologic oncology\| PubMed ID: 19232697	2009
Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Molecular pharmacology\| PubMed ID: 19395473	2009
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19509148	2009
Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society\| PubMed ID: 19574765	2009
Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression. Molecular cancer therapeutics\| PubMed ID: 19887544	2009
Monoclonal antibodies in the treatment of pancreatic cancer. Immunotherapy\| PubMed ID: 20046965	2009
A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer. Pancreas\| PubMed ID: 20182395	2010
DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapy. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 20383593	2011
Overcoming TRAIL resistance in ovarian carcinoma. Gynecologic oncology\| PubMed ID: 20638107	2010
KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model. Clinical & experimental metastasis\| PubMed ID: 20844932	2010
Anti-tumor activity of an anti-DR5 monoclonal antibody, TRA-8, in combination with taxane/platinum-based chemotherapy in an ovarian cancer model. Gynecologic oncology\| PubMed ID: 21211830	2011
Combined modality therapy with TRAIL or agonistic death receptor antibodies. Cancer biology & therapy\| PubMed ID: 21263219	2011
Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. Molecular cancer research : MCR\| PubMed ID: 21357440	2011
Early therapy evaluation of combined cetuximab and irinotecan in orthotopic pancreatic tumor xenografts by dynamic contrast-enhanced magnetic resonance imaging. Molecular imaging\| PubMed ID: 21496446	2011
Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21531776	2011
Treatment of small cell lung cancer with TRA-8 in combination with cisplatin and radiation. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 21722984	2011
Effect of anti-DR5 and chemotherapy on basal-like breast cancer. Breast cancer research and treatment\| PubMed ID: 21901385	2011
Basal-like breast cancer stem cells are sensitive to anti-DR5 mediated cytotoxicity. Breast cancer research and treatment\| PubMed ID: 21915634	2012
Relationship between galectin-3 expression and TRAIL sensitivity in breast cancer. Expert review of anticancer therapy\| PubMed ID: 21916572	2011
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PloS one\| PubMed ID: 21935467	2011
The use of retinoids in ovarian cancer: a review of the literature. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society\| PubMed ID: 22146768	2012
The impact of novel retinoids in combination with platinum chemotherapy on ovarian cancer stem cells. Gynecologic oncology\| PubMed ID: 22155260	2012
Progress in cancer therapy. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 22233333	2012
A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model. Pancreas\| PubMed ID: 22258068	2012
A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer. Gynecologic oncology\| PubMed ID: 22910694	2012
Chapter seven--Cancer treatment with gene therapy and radiation therapy. Advances in cancer research\| PubMed ID: 23021246	2012
ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell lines. Cancer research\| PubMed ID: 23358684	2013
The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells. PloS one\| PubMed ID: 23469146	2013
Lung resistance-related protein (LRP) expression in malignant ascitic cells as a prognostic marker for advanced ovarian serous carcinoma. Annals of surgical oncology\| PubMed ID: 23525731	2013
Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 23836505	2014
Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers. Molecular cancer therapeutics\| PubMed ID: 23883585	2013
The Wnt/β-catenin pathway in ovarian cancer: a review. Gynecologic oncology\| PubMed ID: 24125749	2013
Monoclonal antibody-based immunotherapy of ovarian cancer: targeting ovarian cancer cells with the B7-H3-specific mAb 376.96. Gynecologic oncology\| PubMed ID: 24216048	2014
Will detection of microRNA biomarkers in blood improve the diagnosis and survival of patients with pancreatic cancer? JAMA\| PubMed ID: 24449314	2014
Effect of niclosamide on basal-like breast cancers. Molecular cancer therapeutics\| PubMed ID: 24552774	2014
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug. Cancer letters\| PubMed ID: 24732808	2014
Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer. Gynecologic oncology\| PubMed ID: 24736023	2014
Recurrent read-through fusion transcripts in breast cancer. Breast cancer research and treatment\| PubMed ID: 24929677	2014
Pazopanib combined with radiation: in vivo model of interaction. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 24945464	2014
Combination therapy with anti-DR5 antibody and tamoxifen for triple negative breast cancer. Cancer biology & therapy\| PubMed ID: 25084100	2014
Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival? World journal of stem cells\| PubMed ID: 25258665	2014
S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase. Scientific reports\| PubMed ID: 25677816	2015