Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Journal

Medicine

JoVE Journal
Medicine

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JoVE Journal Medicine

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

DOI:

10.3791/52641-v

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06:24 min

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April 18, 2015

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Hyunki Kim, Sharon Samuel, John W. Totenhagen, Marie Warren, Jeffrey C. Sellers, Donald J. Buchsbaum

¹Radiology,University of Alabama at Birmingham, ²Comprehensive Cancer Center,University of Alabama at Birmingham, ³Radiation Oncology,University of Alabama at Birmingham

Chapters

00:05Title
01:25Orthotopic Pancreatic Tumor Mouse Modeling
02:41Magnetic Resonance Imaging (MRI)
05:04Results: Representative DCE-MR Images and Parametric Maps of an Orthotopic Pancreatic Tumor Xenograft
06:00Conclusion

Summary

Automatic Translation

The goal of this protocol is to apply dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for orthotopic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy.