Eugene C. Butcher

Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine

Affiliated withStanford University School of Medicine Palo Alto Veterans Institute for Research Veterans Affairs Palo Alto Health Care System

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 15	2015
Publication title	2025

Other Publications

Article	Year
Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. The Journal of experimental medicine\| PubMed ID: 11781372	2002
Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. The American journal of pathology\| PubMed ID: 11786428	2002
Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy. Biology of reproduction\| PubMed ID: 11804946	2002
The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. The Journal of experimental medicine\| PubMed ID: 11805153	2002
Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11823530	2002
Chemokines and the tissue-specific migration of lymphocytes. Immunity\| PubMed ID: 11825560	2002
Correlation of tissue distribution, developmental phenotype, and intestinal homing receptor expression of antigen-specific B cells during the murine anti-rotavirus immune response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11859103	2002
Chemokines in rapid leukocyte adhesion triggering and migration. Seminars in immunology\| PubMed ID: 11978080	2002
Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. The Journal of experimental medicine\| PubMed ID: 11994419	2002
Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice. The American journal of pathology\| PubMed ID: 12000715	2002
Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood\| PubMed ID: 12070001	2002
Cytokine control of memory B cell homing machinery. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12165486	2002
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers. Journal of virology\| PubMed ID: 12388703	2002
Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12391210	2002
Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine. The Journal of clinical investigation\| PubMed ID: 12393843	2002
Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression. Trends in immunology\| PubMed ID: 12401396	2002
Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypes. Journal of hepatology\| PubMed ID: 12480562	2003
Rotavirus-specific B cells induced by recent infection in adults and children predominantly express the intestinal homing receptor alpha4beta7. Virology\| PubMed ID: 12504544	2003
Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12538855	2003
CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood\| PubMed ID: 12595306	2003
A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12646646	2003
CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. The Journal of clinical investigation\| PubMed ID: 12671049	2003
Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways. The Journal of experimental medicine\| PubMed ID: 12756264	2003
Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12816993	2003
Chemokines in lymphocyte trafficking and intestinal immunity. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 12851648	2003
Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 12920244	2003
Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12960320	2003
Chemokines in the systemic organization of immunity. Immunological reviews\| PubMed ID: 12969310	2003
Plasma-cell homing. Nature reviews. Immunology\| PubMed ID: 14523388	2003
RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing. Immunity\| PubMed ID: 14738762	2004
Method for analyzing signaling networks in complex cellular systems. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14745015	2004
Targeting T cell responses by selective chemokine receptor expression. Seminars in immunology\| PubMed ID: 15001177	2003
Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsive. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15187103	2004
An integrative biology approach for analysis of drug action in models of human vascular inflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15208272	2004
Unique gene expression program of human germinal center T helper cells. Blood\| PubMed ID: 15213097	2004
Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15240673	2004
Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay and drug development technologies\| PubMed ID: 15357924	2004
CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. The Journal of experimental medicine\| PubMed ID: 15381732	2004
Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children. Journal of virology\| PubMed ID: 15452217	2004
Systems biology in drug discovery. Nature biotechnology\| PubMed ID: 15470465	2004
Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. European journal of immunology\| PubMed ID: 15484189	2004
Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15611246	2005
Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15611250	2005
Modified representational difference analysis: isolation of differentially expressed mRNAs from rare cell populations. Analytical biochemistry\| PubMed ID: 15620887	2005
Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. Journal of cell science\| PubMed ID: 15840656	2005
Can cell systems biology rescue drug discovery? Nature reviews. Drug discovery\| PubMed ID: 15915152	2005
Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15955842	2005
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16034071	2005
Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. The Journal of biological chemistry\| PubMed ID: 16096270	2005
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nature immunology\| PubMed ID: 16116468	2005
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. The Journal of clinical investigation\| PubMed ID: 16239966	2005
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16533754	2006
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nature immunology\| PubMed ID: 16582913	2006
Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16670280	2006
A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16785489	2006
Chemoattractants, extracellular proteases, and the integrated host defense response. Experimental hematology\| PubMed ID: 16863908	2006
Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Experimental hematology\| PubMed ID: 16863918	2006
T cell chemotaxis in a simple microfluidic device. Lab on a chip\| PubMed ID: 17066171	2006
Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditions. Biology of reproduction\| PubMed ID: 17151351	2007
The germinal center response is impaired in the absence of T cell-expressed CXCR5. European journal of immunology\| PubMed ID: 17171760	2007
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nature immunology\| PubMed ID: 17259988	2007
Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17339469	2007
Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in mice. International immunology\| PubMed ID: 17513879	2007
Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. The Journal of biological chemistry\| PubMed ID: 17635925	2007
iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17878364	2007
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood\| PubMed ID: 17989315	2008
Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18566372	2008
Lymphocyte electrotaxis in vitro and in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18684937	2008
Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nature immunology\| PubMed ID: 18711435	2008
Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. The Journal of experimental medicine\| PubMed ID: 18794339	2008
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nature immunology\| PubMed ID: 18836452	2008
An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941222	2008
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. The Journal of biological chemistry\| PubMed ID: 19010784	2009
A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nature medicine\| PubMed ID: 19029985	2008
Modeling the role of homologous receptor desensitization in cell gradient sensing. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19050250	2008
Chemerin and the recruitment of NK cells to diseased skin. Acta biochimica Polonica\| PubMed ID: 19543554	2009
NMR assignment of human chemerin, a novel chemoattractant. Biomolecular NMR assignments\| PubMed ID: 19636857	2007
Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19864606	2009
Dynamic T cell migration program provides resident memory within intestinal epithelium. The Journal of experimental medicine\| PubMed ID: 20156972	2010
Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20833836	2010
Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation. Arthritis and rheumatism\| PubMed ID: 20848566	2010
Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20966033	2011
IL-17 regulates adipogenesis, glucose homeostasis, and obesity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21037091	2010
Panhematin provides a therapeutic benefit in experimental pancreatitis. Gut\| PubMed ID: 21159893	2011
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21220329	2011
Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21715684	2011
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21998451	2011
Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Endocrinology\| PubMed ID: 22186410	2012
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity\| PubMed ID: 22444632	2012
Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis. American journal of physiology. Cell physiology\| PubMed ID: 22460713	2012
Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis. Inflammatory bowel diseases\| PubMed ID: 22488927	2012
Expression, Regulation, and Function of Atypical Chemerin Receptor CCRL2 on Endothelial Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22696441	2012
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. The Journal of experimental medicine\| PubMed ID: 22734047	2012
The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses. The Journal of experimental medicine\| PubMed ID: 22753924	2012
Chemerin is an antimicrobial agent in human epidermis. PloS one\| PubMed ID: 23527010	2013
Thymus-homing dendritic cells in central tolerance. European journal of immunology\| PubMed ID: 23616226	2013
Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses. The Journal of clinical investigation\| PubMed ID: 23635775	2013
Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23677472	2013
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nature immunology\| PubMed ID: 24292363	2014
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing. Nature immunology\| PubMed ID: 25173345	2014
Absence of Nkx2-3 homeodomain transcription factor reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25320278	2014
Leukocyte chemoattractant receptors in human disease pathogenesis. Annual review of pathology\| PubMed ID: 25387059	2015
A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PloS one\| PubMed ID: 25437209	2014
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nature immunology\| PubMed ID: 25531831	2015
Expression of the mucosal homing receptor alpha4beta7 correlates with the ability of CD8+ memory T cells to clear rotavirus infection. Journal of virology\| PubMed ID: 9420279	1998
Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific c... The Journal of experimental medicine\| PubMed ID: 10974041	2000
alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus. The Journal of clinical investigation\| PubMed ID: 11120761	2000
Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. The Journal of clinical investigation\| PubMed ID: 11238560	2001
Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. The Journal of experimental medicine\| PubMed ID: 11413192	2001
Rules of chemokine receptor association with T cell polarization in vivo. The Journal of clinical investigation\| PubMed ID: 11696578	2001
CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. The Journal of experimental medicine\| PubMed ID: 11714760	2001
Can cell systems biology rescue drug discovery? Ernst Schering Research Foundation workshop\| PubMed ID: 17249501	2007
Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal immunology\| PubMed ID: 23235743	2013
Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid. Mucosal immunology\| PubMed ID: 26129652	2016
Leukocyte Trafficking to the Small Intestine and Colon. Gastroenterology\| PubMed ID: 26551552	2016
Vitamin D immunoregulation through dendritic cells. Immunology\| PubMed ID: 27040466	2016
Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo. Blood\| PubMed ID: 27207787	2016
Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge. JCI insight\| PubMed ID: 28352656	2017
Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28972089	2017
A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 29606504	2018
Gut-Selective Integrin-Targeted Therapies for Inflammatory Bowel Disease. Journal of Crohn's & colitis\| PubMed ID: 29767705	2018
Single-cell analysis of early progenitor cells that build coronary arteries. Nature\| PubMed ID: 29973725	2018
Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature. Circulation\| PubMed ID: 30586708	2019
Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry. Bio-protocol\| PubMed ID: 30637296	2018
DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30718413	2019
Papain-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry. Bio-protocol\| PubMed ID: 31032379	2018
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nature medicine\| PubMed ID: 31086348	2019
Exploration of Cell Development Pathways through High-Dimensional Single Cell Analysis in Trajectory Space. iScience\| PubMed ID: 32058956	2020
Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32205425	2020
A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature. Frontiers in cardiovascular medicine\| PubMed ID: 32426372	2020
Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema. American journal of respiratory and critical care medicine\| PubMed ID: 32515984	2020
A molecular map of murine lymph node blood vascular endothelium at single cell resolution. Nature communications\| PubMed ID: 32732867	2020
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. Cell reports\| PubMed ID: 33264627	2020
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss. Circulation research\| PubMed ID: 33375813	2021
A CD22-Shp1 phosphatase axis controls integrin β display and B cell function in mucosal immunity. Nature immunology\| PubMed ID: 33589816	2021
Development of follicular dendritic cells in lymph nodes depends on retinoic acid-mediated signaling. Development (Cambridge, England)\| PubMed ID: 34528674	2021
An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression. Nature communications\| PubMed ID: 36460642	2022
Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 37641406	2023
Secreted IgM modulates IL-10 expression in B cells. Nature communications\| PubMed ID: 38182585	2024
Endothelial cell Notch signaling programs cancer-associated fibroblasts to promote tumor immune evasion. Research square\| PubMed ID: 38947054	2024
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS. Nature\| PubMed ID: 39293486	2024
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes. Cell\| PubMed ID: 39708807	2025