Paul R. Thompson

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School

Affiliated withUniversity of Massachusetts Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 168	2015

Other Publications

Article	Year
Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. Biochemistry\| PubMed ID: 12033933	2002
Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorganic & medicinal chemistry\| PubMed ID: 12837541	2003
Selective HAT inhibitors as mechanistic tools for protein acetylation. Methods in enzymology\| PubMed ID: 14975306	2004
Regulation of the p300 HAT domain via a novel activation loop. Nature structural & molecular biology\| PubMed ID: 15004546	2004
Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 15158807	2004
Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry\| PubMed ID: 16060666	2005
A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. Journal of the American Chemical Society\| PubMed ID: 16433522	2006
Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry\| PubMed ID: 17002273	2006
Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe. Journal of the American Chemical Society\| PubMed ID: 17090024	2006
Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock? ACS chemical biology\| PubMed ID: 17168521	2006
Methyllysine analogs: rewriting the code. Nature chemical biology\| PubMed ID: 17438548	2007
Protein arginine deiminase 4: evidence for a reverse protonation mechanism. Biochemistry\| PubMed ID: 17497940	2007
A selective chemical probe for coenzyme A-requiring enzymes. Angewandte Chemie (International ed. in English)\| PubMed ID: 17768748	2007
Peptide borono lectins (PBLs): a new tool for glycomics and cancer diagnostics. Chembiochem : a European journal of chemical biology\| PubMed ID: 17924602	2007
Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry\| PubMed ID: 17960915	2007
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 17964793	2008
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature\| PubMed ID: 18273021	2008
In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1. Journal of the American Chemical Society\| PubMed ID: 18338885	2008
Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. The Journal of biological chemistry\| PubMed ID: 18499678	2008
Regulation of p53 target gene expression by peptidylarginine deiminase 4. Molecular and cellular biology\| PubMed ID: 18505818	2008
Kinetic mechanism of protein arginine methyltransferase 1. Biochemistry\| PubMed ID: 18771293	2008
The protein acetyltransferase ARD1: a novel cancer drug target? Current cancer drug targets\| PubMed ID: 18991565	2008
The tomato brassinosteroid receptor BRI1 increases binding of systemin to tobacco plasma membranes, but is not involved in systemin signaling. Plant molecular biology\| PubMed ID: 19404750	2009
An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4). Tetrahedron letters\| PubMed ID: 19587776	2008
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Current opinion in drug discovery & development\| PubMed ID: 19736621	2009
Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation. Chembiochem : a European journal of chemical biology\| PubMed ID: 20014086	2010
Characterization and inactivation of an agmatine deiminase from Helicobacter pylori. Bioorganic chemistry\| PubMed ID: 20036411	2010
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry\| PubMed ID: 20469888	2010
A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem : a European journal of chemical biology\| PubMed ID: 20480486	2010
A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1. Molecular bioSystems\| PubMed ID: 20607165	2011
Protein arginine deiminase 4: a target for an epigenetic cancer therapy. Cellular and molecular life sciences : CMLS\| PubMed ID: 20706768	2011
A fluopol-ABPP HTS assay to identify PAD inhibitors. Chemical communications (Cambridge, England)\| PubMed ID: 20740228	2010
Mechanistic studies of agmatine deiminase from multiple bacterial species. Biochemistry\| PubMed ID: 20939536	2010
Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS chemical biology\| PubMed ID: 21265574	2011
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21346230	2011
Boronic acid functionalized peptidyl synthetic lectins: combinatorial library design, peptide sequencing, and selective glycoprotein recognition. ACS combinatorial science\| PubMed ID: 21405093	2011
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21415415	2011
Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. Biochemistry\| PubMed ID: 21417440	2011
Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity. Biochemistry\| PubMed ID: 21466234	2011
Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Developmental biology\| PubMed ID: 21539830	2011
Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS genetics\| PubMed ID: 21655091	2011
Kinase consensus sequences: a breeding ground for crosstalk. ACS chemical biology\| PubMed ID: 21721511	2011
Activity-based protein profiling of protein arginine methyltransferase 1. ACS chemical biology\| PubMed ID: 21838253	2011
The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidi... Journal of medicinal chemistry\| PubMed ID: 21882827	2011
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS chemical biology\| PubMed ID: 22004374	2012
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis and rheumatism\| PubMed ID: 22034172	2012
Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). The Journal of biological chemistry\| PubMed ID: 22219200	2012
Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study. The Journal of biological chemistry\| PubMed ID: 22311970	2012
Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates. Molecular bioSystems\| PubMed ID: 22456874	2012
Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo. Nanomedicine (London, England)\| PubMed ID: 22625207	2012
Potential role for PADI-mediated histone citrullination in preimplantation development. BMC developmental biology\| PubMed ID: 22712504	2012
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22853951	2012
Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis. Biochemistry research international\| PubMed ID: 23019525	2012
Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination. Journal of the American Chemical Society\| PubMed ID: 23030787	2012
Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. BMC cancer\| PubMed ID: 23110523	2012
The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers\| PubMed ID: 23175390	2013
Activation of PAD4 in NET formation. Frontiers in immunology\| PubMed ID: 23264775	2012
The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PloS one\| PubMed ID: 23308284	2013
D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS medicinal chemistry letters\| PubMed ID: 23420624	2012
Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors. ACS chemical biology\| PubMed ID: 23557624	2013
Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers\| PubMed ID: 23576281	2014
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. The Journal of clinical investigation\| PubMed ID: 23722903	2013
Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor. ACS chemical biology\| PubMed ID: 23838530	2013
Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5. Biochemistry\| PubMed ID: 23866019	2013
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. The Journal of biological chemistry\| PubMed ID: 23946480	2013
Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. ACS chemical biology\| PubMed ID: 24274060	2014
Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. ACS chemical biology\| PubMed ID: 24358983	2014
Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circulation research\| PubMed ID: 24425713	2014
Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorganic & medicinal chemistry\| PubMed ID: 24440480	2014
A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. ACS chemical biology\| PubMed ID: 24467619	2014
Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway. Biochimica et biophysica acta\| PubMed ID: 24607566	2014
Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24671707	2014
Pluripotency: citrullination unravels stem cells. Nature chemical biology\| PubMed ID: 24743255	2014
Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates. Journal of neurochemistry\| PubMed ID: 24762056	2014
Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24838349	2014
A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 24889365	2014
Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. Biochemistry\| PubMed ID: 24989433	2014
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Annals of the rheumatic diseases\| PubMed ID: 25104775	2014
Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion. Biochemistry\| PubMed ID: 25485739	2014
Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. Journal of medicinal chemistry\| PubMed ID: 25559347	2015
Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS chemical biology\| PubMed ID: 25621824	2015
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nature chemical biology\| PubMed ID: 25622091	2015
Inhibiting protein arginine deiminases has antioxidant consequences. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25635139	2015
Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Current drug targets\| PubMed ID: 25642720	2015
Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation. Chemical reviews\| PubMed ID: 25970731	2015