David Cribbs

Institute for Brain Aging and Dementia, University of California, Irvine (UCI)

Affiliated withUniversity of California, Irvine (UCI)

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 14	2007
Publication title Cited by 25	2007
Publication title Cited by 19	2007

Other Publications

Article	Year
A P-insertion screen identifying novel X-linked essential genes in Drosophila. Mechanisms of development\| PubMed ID: 11744370	2002
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus. Genetics\| PubMed ID: 11861561	2002
Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell\| PubMed ID: 12150923	2002
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neuroscience letters\| PubMed ID: 12213643	2002
Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development. Development (Cambridge, England)\| PubMed ID: 12490563	2003
Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice. Neuroscience letters\| PubMed ID: 12565127	2003
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochemical research\| PubMed ID: 12608703	2003
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. International immunology\| PubMed ID: 12663680	2003
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiology of disease\| PubMed ID: 12742739	2003
Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumors. Clinical & experimental metastasis\| PubMed ID: 14598882	2003
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. European journal of immunology\| PubMed ID: 14635031	2003
Caspase-mediated degeneration in Alzheimer's disease. The American journal of pathology\| PubMed ID: 15277211	2004
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron\| PubMed ID: 15294141	2004
Mimotopes of conformational epitopes in fibrillar beta-amyloid. Journal of neuroimmunology\| PubMed ID: 15465592	2004
Patterned cell culture inside microfluidic devices. Lab on a chip\| PubMed ID: 15616747	2005
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15661919	2005
Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts. Developmental biology\| PubMed ID: 15680366	2005
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nature methods\| PubMed ID: 16094385	2005
Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. Journal of neuroinflammation\| PubMed ID: 16332263	2005
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch. Vaccine\| PubMed ID: 16368167	2006
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine\| PubMed ID: 16460841	2006
Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant. Journal of cellular biochemistry\| PubMed ID: 16741971	2006
Novel approaches for immunotherapeutic intervention in Alzheimer's disease. Neurochemistry international\| PubMed ID: 16765487	2006
The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways. Development genes and evolution\| PubMed ID: 16773339	2006
Relapsing polychondritis with features of dementia with Lewy bodies. Acta neuropathologica\| PubMed ID: 16832629	2006
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. The Journal of biological chemistry\| PubMed ID: 17056594	2006
External force-assisted cell positioning inside microfluidic devices. Biomedical microdevices\| PubMed ID: 17091393	2007
Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates. DNA and cell biology\| PubMed ID: 17132088	2006
Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182597	2007
Distinct roles for Mediator Cdk8 module subunits in Drosophila development. The EMBO journal\| PubMed ID: 17290221	2007
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers. The Journal of biological chemistry\| PubMed ID: 17545160	2007
Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 17656824	2007
Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization. DNA and cell biology\| PubMed ID: 17961074	2008
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18003852	2007
Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18057195	2007
Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B). Neurochemistry international\| PubMed ID: 18079022	2008
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18385314	2008
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. Journal of neuroinflammation\| PubMed ID: 18400101	2008
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PloS one\| PubMed ID: 18461171	2008
Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster. Development (Cambridge, England)\| PubMed ID: 18508864	2008
Cross-regulatory protein-protein interactions between Hox and Pax transcription factors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18755899	2008
Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice. Journal of neuroinflammation\| PubMed ID: 18823564	2008
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18832152	2008
DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype. Journal of neuroimmunology\| PubMed ID: 18838175	2008
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau patho... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19020010	2008
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I. CNS & neurological disorders drug targets\| PubMed ID: 19275632	2009
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part II. CNS & neurological disorders drug targets\| PubMed ID: 19355929	2009
A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta neuropathologica\| PubMed ID: 19360426	2009
Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19439591	2009
Abeta DNA vaccination for Alzheimer's disease: focus on disease prevention. CNS & neurological disorders drug targets\| PubMed ID: 20205639	2010
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiology of disease\| PubMed ID: 20451612	2010
Low concentrations of anti-AÎ² antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology. Human gene therapy\| PubMed ID: 20528468	2010
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. Journal of Alzheimer's disease : JAD\| PubMed ID: 20555131	2010
Microfluidic Multicompartment Device for Neuroscience Research. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20725530	2003
Anti-11[E]-pyroglutamate-modified amyloid Î² antibodies cross-react with other pathological AÎ² species: relevance for immunotherapy. Journal of neuroimmunology\| PubMed ID: 20864186	2010
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Annals of the New York Academy of Sciences\| PubMed ID: 20955427	2010
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid Î² peptide. Molecular immunology\| PubMed ID: 20970857	2010
An amyloid Î²(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiology of aging\| PubMed ID: 21546126	2011
Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma. Cellular immunology\| PubMed ID: 21641588	2011
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. The American journal of pathology\| PubMed ID: 21704011	2011
Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy. Stroke; a journal of cerebral circulation\| PubMed ID: 21903962	2011
Frontal Cortex Neuropathology in Dementia Pugilistica. Journal of neurotrauma\| PubMed ID: 22017610	2011
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PloS one\| PubMed ID: 22046234	2011
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal Î²-catenin pathway function in an Alzheimer's disease model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22095718	2011
Delivery of a DNA Vaccine for Alzheimer's Disease by Electroporation versus Gene Gun Generates Potent and Similar Immune Responses. Neuro-degenerative diseases\| PubMed ID: 22301697	2012