Manuela M. Santos

Centre de recherche du Centre hospitalier de l'Université de Montréal, Institut du cancer de Montréal

Affiliated withInstitut du cancer de Montréal Université de Montréal Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 74	2015
Publication title Cited by 22	2022
Publication title	2026

Other Publications

Article	Year
Frataxin knockin mouse. FEBS letters\| PubMed ID: 11852098	2002
Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood\| PubMed ID: 12805055	2003
Iron metabolism in mice with partial frataxin deficiency. Cerebellum (London, England)\| PubMed ID: 12880182	2003
Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. Blood\| PubMed ID: 14656877	2004
Genomic structure, promoter activity, and developmental expression of the mouse homologue of the Machado-Joseph disease (MJD) gene. Genomics\| PubMed ID: 15233999	2004
Frataxin overexpressing mice. FEBS letters\| PubMed ID: 15304363	2004
Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood\| PubMed ID: 15914561	2005
Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration. Neurobiology of disease\| PubMed ID: 16442805	2006
Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16565419	2006
Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype. Journal of human genetics\| PubMed ID: 16858508	2006
Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. The American journal of pathology\| PubMed ID: 17255318	2007
Anemia upregulates lipocalin 2 in the liver and serum. Blood cells, molecules & diseases\| PubMed ID: 18519167	2008
Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis? Hepatology (Baltimore, Md.)\| PubMed ID: 19152427	2009
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood\| PubMed ID: 19204324	2009
Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis. International journal of cancer. Journal international du cancer\| PubMed ID: 20669231	2011
Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter. Journal of molecular endocrinology\| PubMed ID: 21971825	2011
Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice. The American journal of pathology\| PubMed ID: 22497726	2012
Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signaling. Inflammation\| PubMed ID: 22544439	2012
Extraction of high added value biological compounds from sardine, sardine-type fish and mackerel canning residues--a review. Materials science & engineering. C, Materials for biological applications\| PubMed ID: 23706190	2013
The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation. European journal of immunology\| PubMed ID: 24643698	2014
Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 25609138	2015
T lymphocyte-derived TNF and IFN-γ repress HFE expression in cancer cells. Molecular immunology\| PubMed ID: 25700349	2015
Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis. Scientific reports\| PubMed ID: 33273556	2020
Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains. BMC cancer\| PubMed ID: 33596864	2021
Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides. Clinical nutrition (Edinburgh, Scotland)\| PubMed ID: 34130031	2021
Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota. BMC microbiology\| PubMed ID: 34583649	2021