Michael K. Lee

Department of Neuroscience, University of Minnesota

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2015

Other Publications

Article	Year
Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice. Neurobiology of aging\| PubMed ID: 11804700	2002
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12084935	2002
No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. American heart journal\| PubMed ID: 12514653	2003
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Human molecular genetics\| PubMed ID: 14645205	2004
Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations. Journal of neurochemistry\| PubMed ID: 14690528	2004
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15317865	2004
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Human molecular genetics\| PubMed ID: 15525661	2005
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15684072	2005
Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiology of aging\| PubMed ID: 15917102	2005
Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity. Journal of neurochemistry\| PubMed ID: 15935070	2005
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15944382	2005
Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice. Neurobiology of disease\| PubMed ID: 16230020	2006
Ruptured left gastric artery aneurysm: unique presentation with hemothorax and hemomediastinum. Cardiovascular and interventional radiology\| PubMed ID: 16283575	2006
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16399671	2006
Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis. Cancer research\| PubMed ID: 16585202	2006
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16597723	2006
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Experimental neurology\| PubMed ID: 17254569	2007
Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases. Neurobiology of aging\| PubMed ID: 17316906	2008
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. The American journal of pathology\| PubMed ID: 17872978	2007
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Human molecular genetics\| PubMed ID: 17981811	2008
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19010849	2008
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19091971	2008
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron\| PubMed ID: 20152114	2010
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human molecular genetics\| PubMed ID: 20185556	2010
Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice. Journal of Alzheimer's disease : JAD\| PubMed ID: 20966549	2011
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. PloS one\| PubMed ID: 21304957	2011
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PloS one\| PubMed ID: 21494637	2011
Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease. Parkinsonism & related disorders\| PubMed ID: 22265140	2012
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Human molecular genetics\| PubMed ID: 22357653	2012
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22399752	2012
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22399753	2012
Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24727327	2014