Anna Huttenlocher

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison

Affiliated withUniversity of Wisconsin-Madison

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 22	2015
Publication title Cited by 14	2017

Other Publications

Article	Year
Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment. Clinical immunology (Orlando, Fla.)\| PubMed ID: 11781063	2002
Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. Journal of cell science\| PubMed ID: 12154072	2002
RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Molecular biology of the cell\| PubMed ID: 12589061	2003
Dynamic imaging of cell-substrate contacts. Methods in enzymology\| PubMed ID: 12624919	2003
Cytokine abnormalities in a patient with eosinophilic fasciitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 12722970	2003
Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain. Neuron\| PubMed ID: 12765611	2003
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nature cell biology\| PubMed ID: 15448700	2004
Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter study. The Journal of pediatrics\| PubMed ID: 15580219	2004
Cell polarization mechanisms during directed cell migration. Nature cell biology\| PubMed ID: 15803131	2005
TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. Journal of leukocyte biology\| PubMed ID: 15845648	2005
Calpain proteases in cell adhesion and motility. International review of cytology\| PubMed ID: 16125543	2005
Regulating cell migration: calpains make the cut. Journal of cell science\| PubMed ID: 16129881	2005
Neutrophil chemotaxis in a patient with neonatal-onset multisystem inflammatory disease and Muckle-Wells syndrome. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 16279571	2005
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Molecular biology of the cell\| PubMed ID: 16280362	2006
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. The Journal of biological chemistry\| PubMed ID: 16436382	2006
Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab on a chip\| PubMed ID: 16511622	2006
The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions. Cell motility and the cytoskeleton\| PubMed ID: 16830345	2006
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Journal of leukocyte biology\| PubMed ID: 16963624	2006
Talin1 regulates TCR-mediated LFA-1 function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17114441	2006
Asymmetric localization of calpain 2 during neutrophil chemotaxis. Molecular biology of the cell\| PubMed ID: 17192410	2007
Wound healing with electric potential. The New England journal of medicine\| PubMed ID: 17229960	2007
Analysis of neutrophil chemotaxis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17416985	2007
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Experimental cell research\| PubMed ID: 17574549	2007
Integrins in cell migration. Methods in enzymology\| PubMed ID: 17697879	2007
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. Journal of cell science\| PubMed ID: 17881499	2007
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Molecular biology of the cell\| PubMed ID: 17928408	2007
Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell host & microbe\| PubMed ID: 18005715	2007
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. The Journal of cell biology\| PubMed ID: 18332219	2008
Adhesions ring: a structural comparison between podosomes and the immune synapse. European journal of cell biology\| PubMed ID: 18343530	2008
Analysis of neutrophil polarization and chemotaxis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18453114	2007
Reverse leukocyte migration can be attractive or repulsive. Trends in cell biology\| PubMed ID: 18468440	2008
The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. Molecular biology of the cell\| PubMed ID: 18480402	2008
Natural killer T-cell autoreactivity leads to a specialized activation state. Blood\| PubMed ID: 18779390	2008
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab on a chip\| PubMed ID: 18818806	2008
Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype. Arthritis and rheumatism\| PubMed ID: 18821685	2008
The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration. Journal of cell science\| PubMed ID: 18840650	2008
Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19097072	2009
Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cellular microbiology\| PubMed ID: 19207728	2009
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 19230472	2009
Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. PLoS pathogens\| PubMed ID: 19247439	2009
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. The Journal of cell biology\| PubMed ID: 19364917	2009
Selective and tunable gradient device for cell culture and chemotaxis study. Lab on a chip\| PubMed ID: 19495465	2009
The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (Cambridge, England)\| PubMed ID: 19570844	2009
Characterization of zebrafish larval inflammatory macrophages. Developmental and comparative immunology\| PubMed ID: 19619578	2009
Innate immunity: wounds burst H2O2 signals to leukocytes. Current biology : CB\| PubMed ID: 19640490	2009
Neutrophil motility in vivo using zebrafish. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19763965	2009
Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions. The Journal of biological chemistry\| PubMed ID: 19833735	2009
Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst. Molecular immunology\| PubMed ID: 19889458	2010
Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19897731	2009
Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation. Molecular biology of the cell\| PubMed ID: 19910490	2010
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). The Journal of biological chemistry\| PubMed ID: 20150423	2010
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Developmental cell\| PubMed ID: 20159593	2010
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PloS one\| PubMed ID: 20479866	2010
Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA syndrome. Arthritis and rheumatism\| PubMed ID: 20506269	2010
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood\| PubMed ID: 20592249	2010
PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20855869	2010
An arrayed high-content chemotaxis assay for patient diagnosis. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20953490	2010
Introduction to the mechanisms of directed cell migration themed issue. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20957298	2010
Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. The Journal of allergy and clinical immunology\| PubMed ID: 21167572	2011
Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish. Journal of leukocyte biology\| PubMed ID: 21248150	2011
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays. Analytical chemistry\| PubMed ID: 21261280	2011
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. The Journal of biological chemistry\| PubMed ID: 21270128	2011
Hax1 regulates neutrophil adhesion and motility through RhoA. The Journal of cell biology\| PubMed ID: 21518791	2011
Imaging podosome dynamics and matrix degradation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21748673	2011
Integrins in cell migration. Cold Spring Harbor perspectives in biology\| PubMed ID: 21885598	2011
A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21900181	2011
Live imaging of LFA-1-dependent T-cell motility and stop signals. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21909914	2012
Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Developmental cell\| PubMed ID: 22014524	2011
Contact-dependent T cell activation and T cell stopping require talin1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22075696	2011
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature\| PubMed ID: 22101434	2011
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cellular microbiology\| PubMed ID: 22188170	2012
Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts. Journal of cell science\| PubMed ID: 22303001	2012
The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis. The Journal of biological chemistry\| PubMed ID: 22679023	2012
Spatiotemporal regulation of Src and its substrates at invadosomes. European journal of cell biology\| PubMed ID: 22823952	2012
Neutrophil reverse migration becomes transparent with zebrafish. Advances in hematology\| PubMed ID: 22844288	2012
Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood\| PubMed ID: 22915642	2012
The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. Journal of cell science\| PubMed ID: 22946052	2012
The role of microtubules in neutrophil polarity and migration in live zebrafish. Journal of cell science\| PubMed ID: 22992461	2012
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. The Journal of cell biology\| PubMed ID: 23045550	2012
Innate immune response to Streptococcus iniae infection in zebrafish larvae. Infection and immunity\| PubMed ID: 23090960	2013
Leukocyte migration from a fish eye's view. Journal of cell science\| PubMed ID: 23104739	2012
Citrullination of fibronectin modulates synovial fibroblast behavior. Arthritis research & therapy\| PubMed ID: 23127210	2012
Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab on a chip\| PubMed ID: 23229806	2013
ECM: chemoattraction but not adhesion. Blood\| PubMed ID: 23449615	2013
Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. Journal of leukocyte biology\| PubMed ID: 23475575	2013
Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab on a chip\| PubMed ID: 23503983	2013
Rational design of a ligand-controlled protein conformational switch. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23569285	2013
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens\| PubMed ID: 23592999	2013
Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 23595955	2013
Interstitial leukocyte migration in vivo. Current opinion in cell biology\| PubMed ID: 23797028	2013
The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation. Biochemical pharmacology\| PubMed ID: 23928188	2013
Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation. PeerJ\| PubMed ID: 24010013	2013
WRAMPing up calcium in migrating cells by localized ER transport. Developmental cell\| PubMed ID: 24091010	2013
Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunological reviews\| PubMed ID: 24117827	2013
Heat shock modulates neutrophil motility in zebrafish. PloS one\| PubMed ID: 24367659	2013
The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages. Blood\| PubMed ID: 24421327	2014
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24497204	2014
Spinning disk confocal imaging of neutrophil migration in zebrafish. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24504955	2014
Characterizing asthma from a drop of blood using neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24711384	2014
Choosing Wisely: the American College of Rheumatology's Top 5 for pediatric rheumatology. Arthritis care & research\| PubMed ID: 24756998	2014
Inflammation and wound repair. Seminars in immunology\| PubMed ID: 24853879	2014
Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae. Eukaryotic cell\| PubMed ID: 24879123	2014
Reply: To PMID 24497204. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24891318	2014
Editorial overview: cell adhesion and migration. Current opinion in cell biology\| PubMed ID: 25179864	2014
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science (New York, N.Y.)\| PubMed ID: 25213377	2014
Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis. Arthritis research & therapy\| PubMed ID: 25280866	2014
Live imaging and gene expression analysis in zebrafish identifies a link between neutrophils and epithelial to mesenchymal transition. PloS one\| PubMed ID: 25372289	2014
Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. The Journal of cell biology\| PubMed ID: 25488917	2014
In vivo imaging and characterization of actin microridges. PloS one\| PubMed ID: 25629723	2015
Neutrophils in host defense: new insights from zebrafish. Journal of leukocyte biology\| PubMed ID: 25717145	2015
Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. The Journal of experimental medicine\| PubMed ID: 25870200	2015
Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development (Cambridge, England)\| PubMed ID: 26015541	2015
Strategies from UW-Madison for rescuing biomedical research in the US. eLife\| PubMed ID: 26122792	2015
Neutrophils in pediatric autoimmune disease. Current opinion in rheumatology\| PubMed ID: 26147757	2015
Neutrophils, wounds, and cancer progression. Developmental cell\| PubMed ID: 26218320	2015
Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D. Biomedical microdevices\| PubMed ID: 26354879	2015
Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. Cellular microbiology\| PubMed ID: 26468080	2016
Neutrophils in the Tumor Microenvironment. Trends in immunology\| PubMed ID: 26700397	2016
Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion. The Journal of biological chemistry\| PubMed ID: 27129278	2016
Neutrophil migration in infection and wound repair: going forward in reverse. Nature reviews. Immunology\| PubMed ID: 27231052	2016
Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration. Developmental cell\| PubMed ID: 27459068	2016
A Zebrafish Model of Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells, and Neutrophils in the Establishment and Control of Sustained Fungemia. Infection and immunity\| PubMed ID: 27481252	2016
The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps. PLoS pathogens\| PubMed ID: 27622514	2016
zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae. Zebrafish\| PubMed ID: 27676647	2017
Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere\| PubMed ID: 27830189	2016
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27837107	2016
Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell reports\| PubMed ID: 28467895	2017
Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell reports\| PubMed ID: 28538177	2017
Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae. Fungal genetics and biology : FG & B\| PubMed ID: 28559109	2017
Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell reports\| PubMed ID: 28591586	2017
Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PloS one\| PubMed ID: 28658259	2017
Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. Journal of cell science\| PubMed ID: 28972134	2017