Carl Cotman

Institute for Brain Aging and Dementia, University of California, Irvine (UCI)

Affiliated withUniversity of California, Irvine (UCI)

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 14	2007
Publication title Cited by 25	2007
Publication title Cited by 19	2007

Other Publications

Article	Year
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neuroscience bulletin\| PubMed ID: 22233886	2012
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11854529	2002
Exercise enhances and protects brain function. Exercise and sport sciences reviews\| PubMed ID: 11991541	2002
The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular medicine\| PubMed ID: 12025818	2002
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behavioral neuroscience\| PubMed ID: 12049325	2002
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta neuropathologica\| PubMed ID: 12070657	2002
Exercise: a behavioral intervention to enhance brain health and plasticity. Trends in neurosciences\| PubMed ID: 12086747	2002
Achieving and maintaining cognitive vitality with aging. Mayo Clinic proceedings. Mayo Clinic\| PubMed ID: 12108606	2002
Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. Journal of neuroscience research\| PubMed ID: 12111841	2002
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Archives of general psychiatry\| PubMed ID: 12150646	2002
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neuroscience letters\| PubMed ID: 12213643	2002
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiology of aging\| PubMed ID: 12392784	2002
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences\| PubMed ID: 12480733	2002
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiology of disease\| PubMed ID: 12505426	2002
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 12551965	2003
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochemical research\| PubMed ID: 12608703	2003
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. International immunology\| PubMed ID: 12663680	2003
Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug news & perspectives\| PubMed ID: 12677194	2002
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (New York, N.Y.)\| PubMed ID: 12702875	2003
Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain research\| PubMed ID: 12706240	2003
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiology of disease\| PubMed ID: 12742739	2003
Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. The Journal of comparative neurology\| PubMed ID: 12900930	2003
Locomotor activity rhythms in dogs vary with age and cognitive status. Behavioral neuroscience\| PubMed ID: 12931965	2003
Response latency in Canis familiaris: mental ability or mental strategy? Behavioral neuroscience\| PubMed ID: 14570555	2003
Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiology of disease\| PubMed ID: 14678756	2003
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental gerontology\| PubMed ID: 15130670	2004
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neuroscience letters\| PubMed ID: 15157993	2004
Isolated executive impairment and associated frontal neuropathology. Dementia and geriatric cognitive disorders\| PubMed ID: 15178954	2004
Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behavioural brain research\| PubMed ID: 15219721	2004
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. The Journal of clinical investigation\| PubMed ID: 15232619	2004
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15282285	2004
Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury. Journal of neuroscience research\| PubMed ID: 15352216	2004
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15385603	2004
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Annals of the New York Academy of Sciences\| PubMed ID: 15591009	2004
Patterned cell culture inside microfluidic devices. Lab on a chip\| PubMed ID: 15616747	2005
The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiology of aging\| PubMed ID: 15653179	2005
Voluntary wheel running improves recovery from a moderate spinal cord injury. Journal of neurotrauma\| PubMed ID: 15665610	2005
Activation of complement pathways after contusion-induced spinal cord injury. Journal of neurotrauma\| PubMed ID: 15684772	2004
Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of aging\| PubMed ID: 15708450	2005
The role of caspase cleavage of tau in Alzheimer disease neuropathology. Journal of neuropathology and experimental neurology\| PubMed ID: 15751224	2005
A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 15795044	2005
Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 15795055	2005
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15858047	2005
Exercise-induced gene expression changes in the rat spinal cord. Gene expression\| PubMed ID: 15892452	2005
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta neuropathologica\| PubMed ID: 15986225	2005
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nature methods\| PubMed ID: 16094385	2005
Nutritional management of brain aging in dogs. Journal of the American Veterinary Medical Association\| PubMed ID: 16178393	2005
The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo. Neurochemical research\| PubMed ID: 16187222	2005
BioVision: an application for the automated image analysis of histological sections. Neurobiology of aging\| PubMed ID: 16271803	2006
Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Archives of neurology\| PubMed ID: 16344336	2006
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine\| PubMed ID: 16460841	2006
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiology of learning and memory\| PubMed ID: 16616528	2006
Neurobiology of exercise. Obesity (Silver Spring, Md.)\| PubMed ID: 16648603	2006
Musashi1 antigen expression in human fetal germinal matrix development. Experimental neurology\| PubMed ID: 16777095	2006
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer... Neurobiology of aging\| PubMed ID: 17055614	2008
External force-assisted cell positioning inside microfluidic devices. Biomedical microdevices\| PubMed ID: 17091393	2007
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiology of aging\| PubMed ID: 17092609	2008
Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochemistry international\| PubMed ID: 17118492	2007
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Investigative ophthalmology & visual science\| PubMed ID: 17197552	2007
Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiology of disease\| PubMed ID: 17292615	2007
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. The European journal of neuroscience\| PubMed ID: 17439482	2007
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiology of aging\| PubMed ID: 17467122	2008
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiology of learning and memory\| PubMed ID: 17587610	2007
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behavioural brain research\| PubMed ID: 17698211	2007
Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends in neurosciences\| PubMed ID: 17765329	2007
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Molecular neurodegeneration\| PubMed ID: 17897471	2007
Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain research\| PubMed ID: 18036576	2008
Voluntary running attenuates age-related deficits following SCI. Experimental neurology\| PubMed ID: 18164294	2008
Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free radical biology & medicine\| PubMed ID: 18258206	2008
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. Journal of neuroinflammation\| PubMed ID: 18400101	2008
Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. The Journal of comparative neurology\| PubMed ID: 18792072	2008
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18832152	2008
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochemical research\| PubMed ID: 18846423	2009
Healthy brain aging: a meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 18945646	2008
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. Journal of Alzheimer's disease : JAD\| PubMed ID: 19096165	2008
Axonal mRNA in uninjured and regenerating cortical mammalian axons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19369540	2009
Î²-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiology of aging\| PubMed ID: 19540623	2011
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 19560099	2009
Physical activity and the maintenance of cognition: learning from animal models. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 19595972	2007
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Experimental gerontology\| PubMed ID: 19735717	2009
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19901336	2009
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature genetics\| PubMed ID: 20154673	2010
AÎ² aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiology of aging\| PubMed ID: 20434811	2012
BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiology of aging\| PubMed ID: 20447733	2012
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiology of disease\| PubMed ID: 20451612	2010
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. Journal of Alzheimer's disease : JAD\| PubMed ID: 20463402	2010
Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20660265	2010
Microfluidic Multicompartment Device for Neuroscience Research. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20725530	2003
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PloS one\| PubMed ID: 20838618	2010
Mild stress facilitates learning and exercise improves retention in aged mice. Experimental gerontology\| PubMed ID: 20951791	2011
Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordrecht, Netherlands)\| PubMed ID: 21336566	2012
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature genetics\| PubMed ID: 21460841	2011
An amyloid Î²(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiology of aging\| PubMed ID: 21546126	2011
Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PloS one\| PubMed ID: 21931796	2011
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PloS one\| PubMed ID: 22046234	2011
Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in É›4 carriers. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 22226798	2012