Christopher Heeschen

Stem Cells & Cancer Group, Spanish National Cancer Research Center

Affiliated withSpanish National Cancer Research Center Queen Mary University of London Queen Mary University of London

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 27	2015

Other Publications

Article	Year
Statins have biphasic effects on angiogenesis. Circulation\| PubMed ID: 11839631	2002
Withdrawal of statins increases event rates in patients with acute coronary syndromes. Circulation\| PubMed ID: 11914253	2002
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. The Journal of clinical investigation\| PubMed ID: 12189247	2002
Withdrawal of statins in patients with acute coronary syndromes. Circulation\| PubMed ID: 12551886	2003
Prognostic significance of angiogenic growth factor serum levels in patients with acute coronary syndromes. Circulation\| PubMed ID: 12566361	2003
Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions. Circulation\| PubMed ID: 12566374	2003
Nicotine promotes arteriogenesis. Journal of the American College of Cardiology\| PubMed ID: 12575981	2003
Soluble CD40 ligand in acute coronary syndromes. The New England journal of medicine\| PubMed ID: 12646667	2003
Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes. Circulation\| PubMed ID: 12668510	2003
Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood\| PubMed ID: 12702503	2003
Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation\| PubMed ID: 12952835	2003
Second hand smoke stimulates tumor angiogenesis and growth. Cancer cell\| PubMed ID: 14522253	2003
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nature medicine\| PubMed ID: 14556003	2003
Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation\| PubMed ID: 14581410	2003
Prognostic value of placental growth factor in patients with acute chest pain. JAMA\| PubMed ID: 14747500	2004
p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization. Circulation research\| PubMed ID: 14752032	2004
Quantitative bedside testing of troponin T: is it equal to laboratory testing? The Cardiac Reader Troponin T (CARE T) study. Clinical laboratory\| PubMed ID: 15000216	2004
111In-labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 15001696	2004
Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation\| PubMed ID: 15037527	2004
Inflammatory markers and coronary artery disease. Current opinion in pharmacology\| PubMed ID: 15063355	2004
Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease. Journal of the American College of Cardiology\| PubMed ID: 15234404	2004
The role of NOS3 in stem cell mobilization. Trends in molecular medicine\| PubMed ID: 15350893	2004
The pro-apoptotic serum activity is an independent mortality predictor of patients with heart failure. European heart journal\| PubMed ID: 15351161	2004
N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes. Circulation\| PubMed ID: 15533869	2004
Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. The Journal of experimental medicine\| PubMed ID: 15623573	2005
Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. Journal of the American College of Cardiology\| PubMed ID: 15653020	2005
Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nature medicine\| PubMed ID: 15665831	2005
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells. The Journal of experimental medicine\| PubMed ID: 15928198	2005
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. The Journal of clinical investigation\| PubMed ID: 16100571	2005
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. Journal of molecular and cellular cardiology\| PubMed ID: 16199052	2005
Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease. Circulation research\| PubMed ID: 16254213	2005
Biochemical monitoring of mTOR inhibitor-based immunosuppression following kidney transplantation: a novel approach for tailored immunosuppressive therapy. Kidney international\| PubMed ID: 16316335	2005
Biomarkers in acute coronary syndromes and their role in diabetic patients. Diabetes & vascular disease research\| PubMed ID: 16334593	2005
Elevated placental growth factor levels are associated with adverse outcomes at four-year follow-up in patients with acute coronary syndromes. Journal of the American College of Cardiology\| PubMed ID: 16412852	2006
Influence of sample type and storage conditions on soluble CD40 ligand assessment. Clinical chemistry\| PubMed ID: 16527885	2006
Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for 'pleiotropic' functions of statin therapy. European heart journal\| PubMed ID: 16621868	2006
Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16902165	2006
Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16983080	2006
Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia. Circulation\| PubMed ID: 17145991	2006
Endothelial progenitor cells participate in nicotine-mediated angiogenesis. Journal of the American College of Cardiology\| PubMed ID: 17174197	2006
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1. Journal of cellular biochemistry\| PubMed ID: 17203465	2007
Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circulation research\| PubMed ID: 17272807	2007
Influence of sample type on soluble CD40 ligand assessment in patients with acute coronary syndromes. Thrombosis research\| PubMed ID: 17337289	2007
Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. Journal of the American College of Cardiology\| PubMed ID: 17572250	2007
Nonbone marrow-derived endothelial progenitor cells: what is their exact location? Circulation research\| PubMed ID: 17967790	2007
Genetically engineered stem cells for therapeutic gene delivery. Current gene therapy\| PubMed ID: 17969558	2007
Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine. Ultrasound in medicine & biology\| PubMed ID: 17996357	2008
Metastatic cancer stem cells: a new target for anti-cancer therapy? Cell cycle (Georgetown, Tex.)\| PubMed ID: 18256530	2008
Concentration of bone marrow total nucleated cells by a point-of-care device provides a high yield and preserves their functional activity. Cell transplantation\| PubMed ID: 18351022	2008
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell stem cell\| PubMed ID: 18371365	2007
More good reasons for adherence to statin therapy during acute coronary syndromes. European heart journal\| PubMed ID: 18676969	2008
The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche. Circulation research\| PubMed ID: 18776043	2008
Prostaglandin E positively modulates endothelial progenitor cell homeostasis: an advanced treatment modality for autologous cell therapy. Journal of vascular research\| PubMed ID: 19142013	2009
cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis. PloS one\| PubMed ID: 19287493	2009
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer. Gastroenterology\| PubMed ID: 19501590	2009
Add some fat to vascular progenitor cell therapy. Circulation research\| PubMed ID: 19542018	2009
Pancreatic cancer stem cells--insights and perspectives. Expert opinion on biological therapy\| PubMed ID: 19723015	2009
Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis. Frontiers in bioscience (Elite edition)\| PubMed ID: 20036905	2010
Cancer stem cells in solid tumors. Seminars in cancer biology\| PubMed ID: 20371287	2010
Pancreatic cancer stem cells - update and future perspectives. Molecular oncology\| PubMed ID: 20580623	2010
Combination of injectable multiple growth factor-releasing scaffolds and cell therapy as an advanced modality to enhance tissue neovascularization. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20689075	2010
Adiponectin pretreatment counteracts the detrimental effect of a diabetic environment on endothelial progenitors. Diabetes\| PubMed ID: 21270275	2011
Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiatin... Stem cells (Dayton, Ohio)\| PubMed ID: 21308861	2011
Pancreatic cancer stem cells: new insights and perspectives. Journal of gastroenterology\| PubMed ID: 21698355	2011
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell stem cell\| PubMed ID: 22056140	2011
EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22096026	2012
Stem cells as the root of pancreatic ductal adenocarcinoma. Experimental cell research\| PubMed ID: 22119145	2012
Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22199368	2012
Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22421149	2012
Immuno-targeting of pancreatic cancer stem cells: A new therapeutic strategy against a devastating disease? Oncoimmunology\| PubMed ID: 22754787	2012
Metastatic cancer stem cells--quo vadis? Clinical chemistry\| PubMed ID: 23288488	2013
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Cell cycle (Georgetown, Tex.)\| PubMed ID: 23428904	2013
Stem cells & pancreatic cancer. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 23561967	2013
Standing out from the crowd: cancer stem cells in hepatocellular carcinoma. Cancer cell\| PubMed ID: 23597561	2013
Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. PloS one\| PubMed ID: 23825539	2013
Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells. PloS one\| PubMed ID: 24204632	2013
Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Molecular cancer therapeutics\| PubMed ID: 24785258	2014
Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice. Gastroenterology\| PubMed ID: 25127677	2014
Intracellular autofluorescence: a biomarker for epithelial cancer stem cells. Nature methods\| PubMed ID: 25262208	2014
K-RasV14I recapitulates Noonan syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25359213	2014
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells. Cancer research\| PubMed ID: 25368022	2014
Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25717063	2015
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment. Gut\| PubMed ID: 25841238	2015
The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells. Gut\| PubMed ID: 25887381	2015