Scott J. Hultgren

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine

Affiliated withWashington University School of Medicine

Research Area

Medicine

Biography

Scott J. Hultgren has not added Biography.
If you are Scott J. Hultgren and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 49	2015

Other Publications

Article	Year
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. The Journal of biological chemistry\| PubMed ID: 11744708	2002
Real-time and equilibrium (19)F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11792867	2002
Role of Escherichia coli curli operons in directing amyloid fiber formation. Science (New York, N.Y.)\| PubMed ID: 11823641	2002
Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Cellular microbiology\| PubMed ID: 11856170	2002
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Molecular microbiology\| PubMed ID: 12010488	2002
Innate defense evicts bacterial squatters. Nature immunology\| PubMed ID: 12087414	2002
Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic Escherichia coli. International journal of antimicrobial agents\| PubMed ID: 12135832	2002
Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin. Journal of bacteriology\| PubMed ID: 12270835	2002
Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis. Journal of bacteriology\| PubMed ID: 12399496	2002
Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria. Journal of combinatorial chemistry\| PubMed ID: 12425608	2002
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation. Cell\| PubMed ID: 12437927	2002
Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli. Infection and immunity\| PubMed ID: 12438384	2002
Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract. International reviews of immunology\| PubMed ID: 12486816	2002
CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infection and immunity\| PubMed ID: 12595465	2003
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12655047	2003
Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly. Journal of bacteriology\| PubMed ID: 12700251	2003
Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides. Bioorganic & medicinal chemistry\| PubMed ID: 12713835	2003
Intracellular bacterial biofilm-like pods in urinary tract infections. Science (New York, N.Y.)\| PubMed ID: 12843396	2003
Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria. Organic & biomolecular chemistry\| PubMed ID: 12929660	2003
Targeting virulence for antimicrobial chemotherapy. Current opinion in pharmacology\| PubMed ID: 14559097	2003
Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14739341	2004
Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney international\| PubMed ID: 14871399	2004
The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. Journal of bacteriology\| PubMed ID: 14996796	2004
Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein. The Journal of urology\| PubMed ID: 15017266	2004
P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli. Journal of bacteriology\| PubMed ID: 15205435	2004
Structural biology: anthrax hijacks host receptor. Nature\| PubMed ID: 15318206	2004
Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis. Trends in microbiology\| PubMed ID: 15337164	2004
Host subversion by formation of intracellular bacterial communities in the urinary tract. Microbes and infection / Institut Pasteur\| PubMed ID: 15380779	2004
Fiber assembly by the chaperone-usher pathway. Biochimica et biophysica acta\| PubMed ID: 15546670	2004
Catalysis of protein folding by chaperones in pathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15583129	2004
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Molecular microbiology\| PubMed ID: 15659162	2005
Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors. Infection and immunity\| PubMed ID: 15664970	2005
Interaction of uropathogenic Escherichia coli with host uroepithelium. Current opinion in microbiology\| PubMed ID: 15694857	2005
Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli. Journal of medicinal chemistry\| PubMed ID: 15715464	2005
Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins. Organic & biomolecular chemistry\| PubMed ID: 15731876	2005
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infection and immunity\| PubMed ID: 15784592	2005
Blueprinting the regulatory response of Escherichia coli to the urinary tract. Trends in microbiology\| PubMed ID: 15936653	2005
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infection and immunity\| PubMed ID: 15972487	2005
Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization. Infection and immunity\| PubMed ID: 16239570	2005
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli. Journal of bacteriology\| PubMed ID: 16267292	2005
NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly. Organic & biomolecular chemistry\| PubMed ID: 16294247	2005
The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16303867	2005
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase. PLoS pathogens\| PubMed ID: 16333395	2005
Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein. Molecular microbiology\| PubMed ID: 16420357	2006
LRP6 holds the key to the entry of anthrax toxin. Cell\| PubMed ID: 16564002	2006
Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16585510	2006
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Molecular cell\| PubMed ID: 16793551	2006
Maturation of intracellular Escherichia coli communities requires SurA. Infection and immunity\| PubMed ID: 16861667	2006
Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli. Bioorganic & medicinal chemistry\| PubMed ID: 16904898	2006
Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16968784	2006
Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infection and immunity\| PubMed ID: 17074856	2007
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17098869	2006
Filamentation by Escherichia coli subverts innate defenses during urinary tract infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17172451	2006
Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod. Molecular bioSystems\| PubMed ID: 17308668	2007
Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cellular microbiology\| PubMed ID: 17490405	2007
Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli. Journal of bacteriology\| PubMed ID: 17496084	2007
Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled. The Journal of biological chemistry\| PubMed ID: 17504765	2007
Crystal structure of the P pilus rod subunit PapA. PLoS pathogens\| PubMed ID: 17511517	2007
Sticky fibers and uropathogenesis: bacterial adhesins in the urinary tract. Future microbiology\| PubMed ID: 17661687	2006
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. Molecular microbiology\| PubMed ID: 18036139	2008
The biology and future prospects of antivirulence therapies. Nature reviews. Microbiology\| PubMed ID: 18079741	2008
Detection of intracellular bacterial communities in human urinary tract infection. PLoS medicine\| PubMed ID: 18092884	2007
Morphological plasticity as a bacterial survival strategy. Nature reviews. Microbiology\| PubMed ID: 18157153	2008
Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infection and immunity\| PubMed ID: 18411285	2008
Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infection and immunity\| PubMed ID: 18474655	2008
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell\| PubMed ID: 18485872	2008
Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli. Bioorganic & medicinal chemistry letters\| PubMed ID: 18499455	2008
Streptozocin-induced diabetic mouse model of urinary tract infection. Infection and immunity\| PubMed ID: 18644886	2008
G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cellular microbiology\| PubMed ID: 18754853	2008
Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19131513	2009
Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli. PLoS pathogens\| PubMed ID: 19229321	2009
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. Journal of bacteriology\| PubMed ID: 19286802	2009
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell host & microbe\| PubMed ID: 19454350	2009
Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development. Infection and immunity\| PubMed ID: 19528211	2009
A murine model of urinary tract infection. Nature protocols\| PubMed ID: 19644462	2009
QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Molecular microbiology\| PubMed ID: 19703104	2009
Structural biology of the chaperone-usher pathway of pilus biogenesis. Nature reviews. Microbiology\| PubMed ID: 19820722	2009
Bacterial adhesion--a source of alternate antibiotic targets. IDrugs : the investigational drugs journal\| PubMed ID: 19844856	2009
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nature chemical biology\| PubMed ID: 19915538	2009
Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018753	2009
Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis. Infection and immunity\| PubMed ID: 20086090	2010
Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis. Infection and immunity\| PubMed ID: 20123719	2010
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infection and immunity\| PubMed ID: 20176795	2010
The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili. Molecular microbiology\| PubMed ID: 20199591	2010
A tale of two pili: assembly and function of pili in bacteria. Trends in microbiology\| PubMed ID: 20378353	2010
Structure-based drug design and optimization of mannoside bacterial FimH antagonists. Journal of medicinal chemistry\| PubMed ID: 20507142	2010
Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. Journal of medicinal chemistry\| PubMed ID: 20586493	2010
Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections. Infection and immunity\| PubMed ID: 20696830	2010
Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS pathogens\| PubMed ID: 20811584	2010
Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli. Microbes and infection / Institut Pasteur\| PubMed ID: 21182979	2011
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin. Structure (London, England : 1993)\| PubMed ID: 21300288	2011
Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity. European journal of medicinal chemistry\| PubMed ID: 21316127	2011
A central metabolic circuit controlled by QseC in pathogenic Escherichia coli. Molecular microbiology\| PubMed ID: 21542868	2011
Antitoxins: therapy for stressed bacteria. Nature chemical biology\| PubMed ID: 21587255	2011
Update on biofilm infections in the urinary tract. World journal of urology\| PubMed ID: 21590469	2012
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature\| PubMed ID: 21637253	2011
CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation. Molecular microbiology\| PubMed ID: 21645131	2011
Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infection and immunity\| PubMed ID: 21690238	2011
Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection. Infection and immunity\| PubMed ID: 21807904	2011
Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Science translational medicine\| PubMed ID: 22089451	2011
Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections? European biophysics journal : EBJ\| PubMed ID: 22237603	2012
Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation. Journal of the American Chemical Society\| PubMed ID: 22260746	2012
Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization. Journal of the American Chemical Society\| PubMed ID: 22360307	2012
Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS microbiology reviews\| PubMed ID: 22404313	2012
Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22431310	2012
Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. Journal of medicinal chemistry\| PubMed ID: 22449031	2012
Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study. Bioorganic & medicinal chemistry\| PubMed ID: 22464688	2012
The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22493266	2012
What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli. Virulence\| PubMed ID: 22546905	2012
Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22645361	2012
Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection. Infection and immunity\| PubMed ID: 22665375	2012
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrobial agents and chemotherapy\| PubMed ID: 22733070	2012
The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. mBio\| PubMed ID: 22829678	2012
Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors. Journal of bacteriology\| PubMed ID: 22984258	2012
Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli. Infection and immunity\| PubMed ID: 22988014	2012
Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific. The Journal of infectious diseases\| PubMed ID: 23002447	2012
Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infection and immunity\| PubMed ID: 23132492	2013
Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics. Virulence\| PubMed ID: 23154288	2012
Dissection of pilus tip assembly by the FimD usher monomer. Journal of molecular biology\| PubMed ID: 23295826	2013
Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infection and immunity\| PubMed ID: 23460515	2013
AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis. Infection and immunity\| PubMed ID: 23460519	2013
The complex interactions of bacterial pathogens and host defenses. Current opinion in microbiology\| PubMed ID: 23518336	2013
Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harbor perspectives in medicine\| PubMed ID: 23545571	2013
Structural and energetic basis of folded-protein transport by the FimD usher. Nature\| PubMed ID: 23579681	2013
Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection. Science translational medicine\| PubMed ID: 23658245	2013
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. The Journal of infectious diseases\| PubMed ID: 23737602	2013
Estrogen and recurrent UTI: what are the facts? Science translational medicine\| PubMed ID: 23785033	2013
From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections. Current urology reports\| PubMed ID: 23832844	2013
Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. Journal of bacteriology\| PubMed ID: 23913319	2013
Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24003161	2013
Escherichia coli biofilms have an organized and complex extracellular matrix structure. mBio\| PubMed ID: 24023384	2013
Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24062463	2013
Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24191013	2013
Molecular basis of usher pore gating in Escherichia coli pilus biogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24297893	2013
Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Organic & biomolecular chemistry\| PubMed ID: 24531242	2014
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG. Nature\| PubMed ID: 25219853	2014
EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice. Science translational medicine\| PubMed ID: 25232179	2014
Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli. mBio\| PubMed ID: 25352623	2014
Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection. Current opinion in infectious diseases\| PubMed ID: 25517222	2015
A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. mBio\| PubMed ID: 25550323	2015
Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection. PLoS pathogens\| PubMed ID: 25569799	2015
Chaos controlled: discovery of a powerful amyloid inhibitor. Molecular cell\| PubMed ID: 25658202	2015
Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice. Pathogens and disease\| PubMed ID: 25663347	2015
Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25675528	2015
Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity. mBio\| PubMed ID: 25827417	2015
Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nature reviews. Microbiology\| PubMed ID: 25853778	2015
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS pathogens\| PubMed ID: 25927232	2015
Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice. Pathogens and disease\| PubMed ID: 25986378	2015
The pilus usher controls protein interactions via domain masking and is functional as an oligomer. Nature structural & molecular biology\| PubMed ID: 26052892	2015