Hanry Yu

Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR)

Affiliated withAgency for Science, Technology and Research (A*STAR)National University of Singapore A*STAR

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 23	2015
Publication title Cited by 6	2021

Other Publications

Article	Year
Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. Biomaterials\| PubMed ID: 12109702	2002
Microcapsules with improved mechanical stability for hepatocyte culture. Biomaterials\| PubMed ID: 12593959	2003
Antisense telomerase induced cell growth inhibition, cell cycle arrest and telomerase activity down-regulation in gastric and colon cancer cells. Anticancer research\| PubMed ID: 12680250	2003
Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. Biomaterials\| PubMed ID: 12699678	2003
Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 12773547	2003
Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues. Life sciences\| PubMed ID: 13679242	2003
Use of ultrathin shell microcapsules of hepatocytes in bioartificial liver-assist device. Tissue engineering\| PubMed ID: 14511471	2003
Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance. Biomaterials\| PubMed ID: 14559002	2003
Strategies for the cryopreservation of microencapsulated cells. Biotechnology and bioengineering\| PubMed ID: 14705003	2004
Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials\| PubMed ID: 15020127	2004
Evaluation of collagen and methylated collagen as gene carriers. International journal of pharmaceutics\| PubMed ID: 15234800	2004
Distribution and functions of kinectin isoforms. Journal of cell science\| PubMed ID: 15316074	2004
Quantitative measurement of collagen methylation by capillary electrophoresis. Electrophoresis\| PubMed ID: 15490447	2004
Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices. Biomaterials\| PubMed ID: 15603810	2005
Application of a polyelectrolyte complex coacervation method to improve seeding efficiency of bone marrow stromal cells in a 3D culture system. Biomaterials\| PubMed ID: 15664642	2005
TGF-beta1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment. Biotechnology and bioengineering\| PubMed ID: 15669090	2005
Scalable encapsulation of hepatocytes by electrostatic spraying. Journal of biotechnology\| PubMed ID: 15831251	2005
A configurable three-dimensional microenvironment in a microfluidic channel for primary hepatocyte culture. Assay and drug development technologies\| PubMed ID: 15871691	2005
Characterization of amphoteric multilayered thin films by means of zeta potential measurements. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 15885992	2005
Encapsulating live cells with water-soluble chitosan in physiological conditions. Journal of biotechnology\| PubMed ID: 15925718	2005
Factors influencing stem cell differentiation into the hepatic lineage in vitro. Journal of gastroenterology and hepatology\| PubMed ID: 15955203	2005
Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells. Journal of biotechnology\| PubMed ID: 16026880	2005
An engineered microenvironment for multidimensional microscopy of live cells. Scanning\| PubMed ID: 16370396	2005
Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture. Tissue engineering\| PubMed ID: 16411812	2005
Detection of telomerase activity in gastric lavage fluid: a novel method to detect gastric cancer. The Journal of surgical research\| PubMed ID: 16427084	2006
3D hepatocyte monolayer on hybrid RGD/galactose substratum. Biomaterials\| PubMed ID: 16904177	2006
Kinectin-dependent assembly of translation elongation factor-1 complex on endoplasmic reticulum regulates protein synthesis. The Journal of biological chemistry\| PubMed ID: 16950774	2006
Improved hepatocyte excretory function by immediate presentation of polarity cues. Tissue engineering\| PubMed ID: 16968159	2006
[Encapsulating hepatocytes with chitosan in physiological conditions]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi\| PubMed ID: 17121357	2006
A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab on a chip\| PubMed ID: 17330160	2007
Characterization of flow direction in microchannels and zebrafish blood vessels by scanning fluorescence correlation spectroscopy. Journal of biomedical optics\| PubMed ID: 17343509	2007
Vitreous cryopreservation of cell-biomaterial constructs involving encapsulated hepatocytes. Tissue engineering\| PubMed ID: 17362134	2007
Transient inter-cellular polymeric linker. Biomaterials\| PubMed ID: 17512584	2007
Perfusion culture improves the maintenance of cultured liver tissue slices. Tissue engineering\| PubMed ID: 17518593	2007
Identification and characterization of a novel prespheroid 3-dimensional hepatocyte monolayer on galactosylated substratum. Tissue engineering\| PubMed ID: 17518743	2007
A practical guide to microfluidic perfusion culture of adherent mammalian cells. Lab on a chip\| PubMed ID: 17538709	2007
Multifunctional fluorescence correlation microscope for intracellular and microfluidic measurements. The Review of scientific instruments\| PubMed ID: 17552829	2007
Novel intra-tissue perfusion system for culturing thick liver tissue. Tissue engineering\| PubMed ID: 17708717	2007
Synthetic sandwich culture of 3D hepatocyte monolayer. Biomaterials\| PubMed ID: 17964646	2008
In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor. Leukemia research\| PubMed ID: 18160102	2008
Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection. The Analyst\| PubMed ID: 18299746	2008
A gel-free 3D microfluidic cell culture system. Biomaterials\| PubMed ID: 18455231	2008
Dendrimer hydrazides as multivalent transient inter-cellular linkers. Biomaterials\| PubMed ID: 18554713	2008
Microfabricated silicon nitride membranes for hepatocyte sandwich culture. Biomaterials\| PubMed ID: 18635259	2008
Spreading of an anchorage-dependent cell on a selectively ligand-coated substrate mediated by receptor-ligand binding. Journal of biomedical materials research. Part A\| PubMed ID: 19051302	2009
Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies. Journal of biomedical optics\| PubMed ID: 19123657	2008
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. Blood\| PubMed ID: 19144991	2009
Stem cells in microfluidics. Biotechnology progress\| PubMed ID: 19205022	2009
The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system. Biomaterials\| PubMed ID: 19394078	2009
Line scan fluorescence correlation spectroscopy for three-dimensional microfluidic flow velocity measurements. Journal of biomedical optics\| PubMed ID: 19405777	2009
The use of vitrification to preserve primary rat hepatocyte monolayer on collagen-coated poly(ethylene-terephthalate) surfaces for a hybrid liver support system. Biomaterials\| PubMed ID: 19477507	2009
A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab on a chip\| PubMed ID: 19568671	2009
Laminar-flow immediate-overlay hepatocyte sandwich perfusion system for drug hepatotoxicity testing. Biomaterials\| PubMed ID: 19646750	2009
Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. Journal of biomedical optics\| PubMed ID: 19725725	2009
Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab on a chip\| PubMed ID: 19865724	2009
Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies. Biomaterials\| PubMed ID: 19889455	2010
The steady states and dynamics of urokinase-mediated plasmin activation. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing\| PubMed ID: 19908371	2010
Cell culture on MEMS platforms: a review. International journal of molecular sciences\| PubMed ID: 20054478	2009
Cell-delivery therapeutics for liver regeneration. Advanced drug delivery reviews\| PubMed ID: 20193722	2010
Rapid construction of mechanically- confined multi- cellular structures using dendrimeric intercellular linker. Biomaterials\| PubMed ID: 20599265	2010
Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering. Biomaterials\| PubMed ID: 20691470	2010
A robust high-throughput sandwich cell-based drug screening platform. Biomaterials\| PubMed ID: 20971505	2011
Kinectin-mediated endoplasmic reticulum dynamics supports focal adhesion growth in the cellular lamella. Journal of cell science\| PubMed ID: 20980389	2010
Toward surface quantification of liver fibrosis progression. Journal of biomedical optics\| PubMed ID: 21054101	2010
Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy. Journal of biomedical optics\| PubMed ID: 21054110	2010
Purpose-driven biomaterials research in liver-tissue engineering. Trends in biotechnology\| PubMed ID: 21129798	2011
Current development of bioreactors for extracorporeal bioartificial liver (Review). Biointerphases\| PubMed ID: 21171705	2010
PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy. PloS one\| PubMed ID: 21589872	2011
Galactosylated cellulosic sponge for multi-well drug safety testing. Biomaterials\| PubMed ID: 21741702	2011
Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics. Biomicrofluidics\| PubMed ID: 21799710	2011
Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro. Biophysical journal\| PubMed ID: 22004735	2011
Spatially organized in vitro models instruct asymmetric stem cell differentiation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 22028041	2011
Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis. PloS one\| PubMed ID: 22073152	2011
Influence of cell culture configuration on the post-cryopreservation viability of primary rat hepatocytes. Biomaterials\| PubMed ID: 22079007	2012
Assessment of liver steatosis and fibrosis in rats using integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique. Journal of biomedical optics\| PubMed ID: 22112129	2011
Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development. Lab on a chip\| PubMed ID: 22146879	2012
Tethered spheroids as an in vitro hepatocyte model for drug safety screening. Biomaterials\| PubMed ID: 22189144	2012
Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS biology\| PubMed ID: 22205879	2011
Automated scoring of liver fibrosis through combined features from different collagen groups. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 22255339	2011
Hepatitis C virus network based classification of hepatocellular cirrhosis and carcinoma. PloS one\| PubMed ID: 22493692	2012
FUSE: a profit maximization approach for functional summarization of biological networks. BMC bioinformatics\| PubMed ID: 22536894	2012
HGF regulates the activation of TGF-β1 in rat hepatocytes and hepatic stellate cells. Journal of cellular physiology\| PubMed ID: 22718393	2013
Hepatocyte function within a stacked double sandwich culture plate cylindrical bioreactor for bioartificial liver system. Biomaterials\| PubMed ID: 22889484	2012
Development of a modified vitrification strategy suitable for subsequent scale-up for hepatocyte preservation. Cryobiology\| PubMed ID: 22940432	2012
Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1. Biophysical journal\| PubMed ID: 23009856	2012
Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza. PloS one\| PubMed ID: 23119022	2012
Mechanical compaction directly modulates the dynamics of bile canaliculi formation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23233209	2013
Direct detection of collagenous proteins by fluorescently labeled collagen mimetic peptides. Bioconjugate chemistry\| PubMed ID: 23253177	2013
Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fib... Human gene therapy\| PubMed ID: 23527815	2013
Spatiotemporal quantification of cell dynamics in the lung following influenza virus infection. Journal of biomedical optics\| PubMed ID: 23545853	2013
Scalable cell alignment on optical media substrates. Biomaterials\| PubMed ID: 23601659	2013
In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques. ALTEX\| PubMed ID: 23861079	2013
A cellular pathway involved in Clara cell to alveolar type II cell differentiation after severe lung injury. PloS one\| PubMed ID: 23940685	2013
Scalable alignment of three-dimensional cellular constructs in a microfluidic chip. Lab on a chip\| PubMed ID: 23969512	2013
Correlation of MR elastography with morphometric quantification of liver fibrosis (Fibro-C-Index) in chronic hepatitis B. Magnetic resonance in medicine\| PubMed ID: 24166665	2014
Label-free virus identification and characterization using electrochemical impedance spectroscopy. Electrophoresis\| PubMed ID: 24285469	2014
qFibrosis: a fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients. Journal of hepatology\| PubMed ID: 24583249	2014
Experimenting liver fibrosis diagnostic by two photon excitation microscopy and Bag-of-Features image classification. Scientific reports\| PubMed ID: 24717650	2014
Scalable spheroid model of human hepatocytes for hepatitis C infection and replication. Molecular pharmaceutics\| PubMed ID: 24761996	2014
Reassignment of scattered emission photons in multifocal multiphoton microscopy. Scientific reports\| PubMed ID: 24898470	2014
The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation. PLoS computational biology\| PubMed ID: 24901250	2014
Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. Respiratory research\| PubMed ID: 25265939	2014
On-chip controlled surfactant-DNA coil-globule transition by rapid solvent exchange using hydrodynamic flow focusing. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 25351469	2014
In vivo label-free quantification of liver microcirculation using dual-modality microscopy. Journal of biomedical optics\| PubMed ID: 25388810	2014
HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening. Journal of applied toxicology : JAT\| PubMed ID: 25512232	2015
Differential remodeling of extracellular matrices by breast cancer initiating cells. Journal of biophotonics\| PubMed ID: 25597396	2015
Modulation of integrin and E-cadherin-mediated adhesions to spatially control heterogeneity in human pluripotent stem cell differentiation. Biomaterials\| PubMed ID: 25736499	2015
A method for human teratogen detection by geometrically confined cell differentiation and migration. Scientific reports\| PubMed ID: 25966467	2015
Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface. Journal of biophotonics\| PubMed ID: 26131709	2015
Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stress. Journal of neurochemistry\| PubMed ID: 26195140	2015
Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model. Journal of applied toxicology : JAT\| PubMed ID: 26201057	2015
Second harmonic generation microscopy is a novel technique for differential diagnosis of breast fibroepithelial lesions. Journal of clinical pathology\| PubMed ID: 26209730	2015
Corrigendum: A method for human teratogen detection by geometrically confined cell differentiation and migration. Scientific reports\| PubMed ID: 26237348	2015
Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Biomaterials\| PubMed ID: 26310107	2015
Constrained spheroids for prolonged hepatocyte culture. Biomaterials\| PubMed ID: 26708088	2016
Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension. Nature cell biology\| PubMed ID: 26878396	2016
Functionally Enhanced Human Stem Cell Derived Hepatocytes in Galactosylated Cellulosic Sponges for Hepatotoxicity Testing. Molecular pharmaceutics\| PubMed ID: 27157693	2016
Fluorescent probes for nanoscopy: four categories and multiple possibilities. Journal of biophotonics\| PubMed ID: 27221311	2017
Kinectin-dependent ER transport supports the focal complex maturation required for chemotaxis in shallow gradients. Journal of cell science\| PubMed ID: 27221621	2016
Aggregation and protein corona formation on gold nanoparticles affect viability and liver functions of primary rat hepatocytes. Nanomedicine (London, England)\| PubMed ID: 27527273	2016
Heralding a new paradigm in 3D tumor modeling. Biomaterials\| PubMed ID: 27639438	2016
Butein and Its Role in Chronic Diseases. Advances in experimental medicine and biology\| PubMed ID: 27671826	2016
A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions. Lab on a chip\| PubMed ID: 27722715	2016
Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Scientific reports\| PubMed ID: 28120901	2017
Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis. Journal of hepatology\| PubMed ID: 28189756	2017
25-Hydroxyvitamin D induces osteogenic differentiation of human mesenchymal stem cells. Scientific reports\| PubMed ID: 28211493	2017
3D Culture as a Clinically Relevant Model for Personalized Medicine. SLAS technology\| PubMed ID: 28277923	2017
Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals. Stem cells translational medicine\| PubMed ID: 28297582	2017
A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells. Biotechnology and bioengineering\| PubMed ID: 28542705	2017
Development of a classification model for non-alcoholic steatohepatitis (NASH) using confocal Raman micro-spectroscopy. Journal of biophotonics\| PubMed ID: 28635128	2017
Mechanosensing in liver regeneration. Seminars in cell & developmental biology\| PubMed ID: 28768152	2017
In Vitro Micropatterned Human Pluripotent Stem Cell Test (µP-hPST) for Morphometric-Based Teratogen Screening. Scientific reports\| PubMed ID: 28819231	2017
A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing. Scientific reports\| PubMed ID: 29109520	2017
Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model. BMC systems biology\| PubMed ID: 29322934	2017
Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer. Biomaterials\| PubMed ID: 29353739	2018
TGFβ1-mediated suppression of cytochrome P450(CYP) induction responses in rat hepatocyte-fibroblast co-cultures. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 29366910	2018
Directed Differentiation of Adult Liver Derived Mesenchymal Like Stem Cells into Functional Hepatocytes. Scientific reports\| PubMed ID: 29434311	2018
A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion. Bioengineering (Basel, Switzerland)\| PubMed ID: 29642502	2018
Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29768267	2018
Datasets describing the growth and molecular features of hepatocellular carcinoma patient-derived xenograft cells grown in a three-dimensional macroporous hydrogel. Data in brief\| PubMed ID: 29900213	2018
PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell research\| PubMed ID: 29934616	2018
Constrained spheroids/organoids in perfusion culture. Methods in cell biology\| PubMed ID: 30037466	2018
Author Correction: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell research\| PubMed ID: 30038297	2018
Metabolic Remodeling during Liver Regeneration. Developmental cell\| PubMed ID: 30344111	2018
Deep learning enables automated scoring of liver fibrosis stages. Scientific reports\| PubMed ID: 30375454	2018
Cleavable cellulosic sponge for functional hepatic cell culture and retrieval. Biomaterials\| PubMed ID: 30784769	2019
Self-assembling amyloid-like peptides as exogenous second harmonic probes for bioimaging applications. Journal of biophotonics\| PubMed ID: 31162811	2019
Hepatic spheroids used as an in vitro model to study malaria relapse. Biomaterials\| PubMed ID: 31195301	2019
Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy. Nature communications\| PubMed ID: 31409824	2019
Sequential drug delivery for liver diseases. Advanced drug delivery reviews\| PubMed ID: 31734169	2019
IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease. Clinical science (London, England : 1979)\| PubMed ID: 31934720	2020
Decellularized liver as a translucent ex vivo model for vascular embolization evaluation. Biomaterials\| PubMed ID: 32070824	2020
Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing. Scientific reports\| PubMed ID: 32179810	2020
Biomimetic niches reveal the minimal cues to trigger apical lumen formation in single hepatocytes. Nature materials\| PubMed ID: 32341512	2020
Functional Stem Cell Sorting via Integrative Droplet Synchronization. Analytical chemistry\| PubMed ID: 32378402	2020
Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials\| PubMed ID: 32827796	2020
Hydrogel-based colorectal cancer organoid co-culture models. Acta biomaterialia\| PubMed ID: 33388439	2020
Substrate Stiffness Modulates the Maturation of Human Pluripotent Stem-Cell-Derived Hepatocytes. ACS biomaterials science & engineering\| PubMed ID: 33440598	2016
Three-Dimensional Macroporous Sponge for the Culture of Hepatocellular Carcinoma Patient-Derived Xenograft Organoids. SLAS technology\| PubMed ID: 33775155	2021