Kezhong Zhang

Center for Molecular Medicine and Genetics, Wayne State University

Research Area

Biography

Kezhong Zhang has not added Biography.
If you are Kezhong Zhang and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 73	2016

Other Publications

Article	Year
Genetic mechanisms of age regulation of protein C and blood coagulation. The Journal of biological chemistry\| PubMed ID: 11719515	2002
New function for age-related stability element in conferring strict tissue-specific expression of human factor IX and protein C genes. Thrombosis and haemostasis\| PubMed ID: 12353089	2002
Limitation in use of heterologous reporter genes for gene promoter analysis. Silencer activity associated with the cloramphenicol acetyltransferase reporter gene. The Journal of biological chemistry\| PubMed ID: 12473656	2003
Bone marrow stromal cells as a genetic platform for systemic delivery of therapeutic proteins in vivo: human factor IX model. The journal of gene medicine\| PubMed ID: 12516047	2003
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. The Journal of biological chemistry\| PubMed ID: 12738777	2003
Unfolding the toxicity of cholesterol. Nature cell biology\| PubMed ID: 12951604	2003
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature\| PubMed ID: 15029200	2004
Signaling the unfolded protein response from the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 15070890	2004
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. Journal of chemical neuroanatomy\| PubMed ID: 15363493	2004
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. The Journal of clinical investigation\| PubMed ID: 15690081	2005
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (San Diego, Calif.)\| PubMed ID: 15804613	2005
The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology\| PubMed ID: 16432136	2006
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell\| PubMed ID: 16469704	2006
From endoplasmic-reticulum stress to the inflammatory response. Nature\| PubMed ID: 18650916	2008
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods in enzymology\| PubMed ID: 18662581	2008
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element bind... Hepatology (Baltimore, Md.)\| PubMed ID: 18704925	2008
Association study of semaphorin 5A with risk of Parkinson's disease in a Chinese Han population. Brain research\| PubMed ID: 18950607	2008
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19011102	2008
An age-related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416882	2009
Regulation of apoptosis by the unfolded protein response. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19609758	2009
ER stress controls iron metabolism through induction of hepcidin. Science (New York, N.Y.)\| PubMed ID: 19679815	2009
Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. American journal of translational research\| PubMed ID: 20182583	2010
Integration of ER stress, oxidative stress and the inflammatory response in health and disease. International journal of clinical and experimental medicine\| PubMed ID: 20369038	2010
The comparison of clonidine, arginine and both combined: a growth hormone stimulation test to differentiate multiple system atrophy from idiopathic Parkinson's disease. Journal of neurology\| PubMed ID: 20405138	2010
Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. American journal of physiology. Cell physiology\| PubMed ID: 20554909	2010
Role of unfolded protein response in lipogenesis. World journal of hepatology\| PubMed ID: 21160998	2010
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. Methods in enzymology\| PubMed ID: 21266239	2011
Unfolded protein response in cancer: the physician's perspective. Journal of hematology & oncology\| PubMed ID: 21345215	2011
Real-world exposure of airborne particulate matter triggers oxidative stress in an animal model. International journal of physiology, pathophysiology and pharmacology\| PubMed ID: 21383899	2010
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. The EMBO journal\| PubMed ID: 21407177	2011
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon meta... Hepatology (Baltimore, Md.)\| PubMed ID: 22095841	2011
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. American journal of translational research\| PubMed ID: 22347525	2012
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. Toxicology letters\| PubMed ID: 22414386	2012
Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes. Biochemistry research international\| PubMed ID: 22506114	2012
ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC cancer\| PubMed ID: 22681620	2012
Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells. The Biochemical journal\| PubMed ID: 22690709	2012
Endoplasmic reticulum stress and lipid metabolism. Biochemistry research international\| PubMed ID: 22778961	2012
Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. Journal of hepatology\| PubMed ID: 22902548	2013
Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. American journal of translational research\| PubMed ID: 22937203	2012
Aquaporin-assisted and ER-mediated mitochondrial fission: a hypothesis. Micron (Oxford, England : 1993)\| PubMed ID: 23416165	2013
Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. American journal of translational research\| PubMed ID: 23573366	2013
The association between glycogen synthase kinase 3 beta (GSK3-Î²) polymorphisms and Parkinson's disease susceptibility: A meta-analysis. Gene\| PubMed ID: 23628795	2013
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. The EMBO journal\| PubMed ID: 23942232	2013
The serine-threonine kinase Inositol-requiring enzyme 1 Î± (IRE1Î±) promotes IL-4 production in T helper cells. The Journal of biological chemistry\| PubMed ID: 24100031	2013
Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area. PloS one\| PubMed ID: 24386416	2013
Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21. Endocrinology\| PubMed ID: 24424044	2014
Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study. Psychoneuroendocrinology\| PubMed ID: 24703171	2014
Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24735884	2014
Correlations between plasma levels of amino acids and nonmotor symptoms in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 25059457	2015
PM2.5 in Beijing - temporal pattern and its association with influenza. Environmental health : a global access science source\| PubMed ID: 25471661	2014
Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells. Proteomics\| PubMed ID: 25546123	2015
Endoplasmic reticulum stress response and transcriptional reprogramming. Frontiers in genetics\| PubMed ID: 25709614	2014
Cross talk between ER stress, oxidative stress, and inflammation in health and disease. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25804758	2015
Genome-wide identification, evolutionary, and expression analyses of histone H3 variants in plants. BioMed research international\| PubMed ID: 25815311	2015
SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. Scientific reports\| PubMed ID: 25985281	2015
Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment. The International journal of neuroscience\| PubMed ID: 26004911	2016
Plasma antioxidant status and motor features in de novo Chinese Parkinson's disease patients. The International journal of neuroscience\| PubMed ID: 26010212	2016
Reduced plasma serotonin and 5-hydroxyindoleacetic acid levels in Parkinson's disease are associated with nonmotor symptoms. Parkinsonism & related disorders\| PubMed ID: 26028271	2015
Petroleum coke in the urban environment: a review of potential health effects. International journal of environmental research and public health\| PubMed ID: 26035666	2015
COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 26083833	2015
Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models. Journal of hepatology\| PubMed ID: 26220751	2015
Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism. Molecular and cellular biology\| PubMed ID: 26438600	2015
Regional homogeneity alterations differentiate between tremor dominant and postural instability gait difficulty subtypes of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 26666253	2016
[Study on changes of plasma levels of oxidative stress biomarkers and its relation with cognition function in patients with parkinson's disease]. Zhonghua yi xue za zhi\| PubMed ID: 26812976	2015
Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes. Genomics data\| PubMed ID: 26981370	2016
Alterations of functional and structural connectivity of freezing of gait in Parkinson's disease. Journal of neurology\| PubMed ID: 27230857	2016
A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. Cell discovery\| PubMed ID: 27462423	2015
Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology (Baltimore, Md.)\| PubMed ID: 27480224	2016
CREBH Couples Circadian Clock With Hepatic Lipid Metabolism. Diabetes\| PubMed ID: 27507854	2016
COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy. Scientific reports\| PubMed ID: 27550821	2016
Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573825	2016
Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis. Scientific reports\| PubMed ID: 27582413	2016
Inositol Requiring Enzyme 1 Facilitates Diabetic Wound Healing through Modulating microRNAs. Diabetes\| PubMed ID: 27634225	2016
Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin. The Journal of biological chemistry\| PubMed ID: 27637329	2016
Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 27878377	2016
ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis. Journal of clinical & cellular immunology\| PubMed ID: 27942420	2016