Christine Allen

Leslie Dan Faculty of Pharmacy, University of Toronto

Affiliated withUniversity of Toronto University Health Network University Health Network

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 17	2015
Publication title Cited by 6	2016
Publication title Cited by 2	2016

Other Publications

Article	Year
"Swollen" Macrocycles: Palladium(II)-Directed Template Syntheses of Pendant-Arm 14-, 16-, and 18-Membered Macrocycles. Inorganic chemistry\| PubMed ID: 11666700	1996
Polymer-drug compatibility: a guide to the development of delivery systems for the anticancer agent, ellipticine. Journal of pharmaceutical sciences\| PubMed ID: 14648643	2004
pH gradient loading of anthracyclines into cholesterol-free liposomes: enhancing drug loading rates through use of ethanol. Biochimica et biophysica acta\| PubMed ID: 14967474	2004
Synthesis and characterization of biodegradable poly(ethylene glycol)-block-poly(5-benzyloxy-trimethylene carbonate) copolymers for drug delivery. Biomacromolecules\| PubMed ID: 15360292	2004
Engineering lipobeads: properties of the hydrogel core and the lipid bilayer shell. Biomacromolecules\| PubMed ID: 15530037	2004
Monodisperse chitosan nanoparticles for mucosal drug delivery. Biomacromolecules\| PubMed ID: 15530064	2004
Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15763628	2005
In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15866344	2005
Synthesis and characterization of six-arm star poly(delta-valerolactone)-block-methoxy poly(ethylene glycol) copolymers. Biomacromolecules\| PubMed ID: 16004456	2005
How well are we caring for caregivers? Prevalence of grief-related symptoms and need for bereavement support among long-term care staff. Journal of pain and symptom management\| PubMed ID: 16183006	2005
Methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for formulation of hydrophobic drugs. Biomacromolecules\| PubMed ID: 16283736	2005
Liposome formulation of a novel hydrophobic aryl-imidazole compound for anti-cancer therapy. Cancer chemotherapy and pharmacology\| PubMed ID: 16333677	2006
Multimodal contrast agent for combined computed tomography and magnetic resonance imaging applications. Investigative radiology\| PubMed ID: 16481918	2006
Epidermal growth factor-conjugated poly(ethylene glycol)-block- poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics. Bioconjugate chemistry\| PubMed ID: 16536472	2006
Synthesis and physicochemical and dynamic mechanical properties of a water-soluble chitosan derivative as a biomaterial. Biomacromolecules\| PubMed ID: 17025361	2006
Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 17113177	2007
Synthesis and physicochemical and dynamic mechanical properties of a water-soluble chitosan derivative as a biomaterial. Biomacromolecules\| PubMed ID: 17154488	2006
In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 17257817	2007
In vivo performance of a liposomal vascular contrast agent for CT and MR-based image guidance applications. Pharmaceutical research\| PubMed ID: 17373581	2007
Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model. Cancer chemotherapy and pharmacology\| PubMed ID: 17375303	2007
Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding. Biochimica et biophysica acta\| PubMed ID: 17400180	2007
Long-circulating poly(ethylene glycol)-coated emulsions to target solid tumors. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 17490868	2007
Predicting the solubility of the anti-cancer agent docetaxel in small molecule excipients using computational methods. Pharmaceutical research\| PubMed ID: 17705028	2008
Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy. Molecular pharmaceutics\| PubMed ID: 17867644	2007
Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy. Photochemistry and photobiology\| PubMed ID: 18028227	2007
Nano-sized assemblies of a PEG-docetaxel conjugate as a formulation strategy for docetaxel. Journal of pharmaceutical sciences\| PubMed ID: 18064681	2008
Drug release mechanism of paclitaxel from a chitosan-lipid implant system: effect of swelling, degradation and morphology. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18164931	2008
Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer. Molecular cancer therapeutics\| PubMed ID: 18347149	2008
Influence of molecular organization and interactions on drug release for an injectable polymer-lipid blend. International journal of pharmaceutics\| PubMed ID: 18550303	2008
Intermolecular interactions and morphology of aqueous polymer/surfactant mixtures containing cationic chitosan and nonionic sorbitan esters. Biomacromolecules\| PubMed ID: 18605692	2008
Morphological control of poly(ethylene glycol)-block-poly(epsilon-caprolactone) copolymer aggregates in aqueous solution. Biomacromolecules\| PubMed ID: 18702541	2008
Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model. Molecular pharmaceutics\| PubMed ID: 19298061	2009
Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19376167	2009
Biocompatibility of injectable chitosan-phospholipid implant systems. Biomaterials\| PubMed ID: 19394688	2009
Chitosan-phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity. International journal of pharmaceutics\| PubMed ID: 19442712	2009
Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 19447206	2010
Intracellular uptake, transport, and processing of nanostructures in cancer cells. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 19480047	2009
Sixth International Nanomedicine and Drug Delivery Symposium (NanoDDS'08). Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19567258	2009
Enhancement of docetaxel solubility via conjugation of formulation-compatible moieties. Organic & biomolecular chemistry\| PubMed ID: 19675898	2009
Noninvasive monitoring of the fate of 111In-labeled block copolymer micelles by high resolution and high sensitivity microSPECT/CT imaging. Molecular pharmaceutics\| PubMed ID: 19718806	2009
Multifunctional block copolymer micelles for the delivery of 111In to EGFR-positive breast cancer cells for targeted Auger electron radiotherapy. Molecular pharmaceutics\| PubMed ID: 19924993	2010
In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels. Pharmaceutical research\| PubMed ID: 20195708	2010
Poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles containing chemically conjugated and physically entrapped docetaxel: synthesis, characterization, and the influence of the drug on... Biomacromolecules\| PubMed ID: 20369884	2010
Polymeric drug delivery systems for localized cancer chemotherapy. Drug delivery\| PubMed ID: 20429844	2010
The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Molecular pharmaceutics\| PubMed ID: 20476759	2010
Utility of transdermal fentanyl for prevention of iatrogenic opioid abstinence syndrome in children. Journal of opioid management\| PubMed ID: 20481176	2010
Gold nanoparticles as radiation sensitizers in cancer therapy. Radiation research\| PubMed ID: 20518651	2010
Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancer. Molecular cancer therapeutics\| PubMed ID: 20530719	2010
Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology. Contrast media & molecular imaging\| PubMed ID: 20586032	2010
Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer. Molecular pharmaceutics\| PubMed ID: 21166459	2011
Docetaxel distribution following intraperitoneal administration in mice. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques\| PubMed ID: 21501556	2011
Chemotherapy dosing schedule influences drug resistance development in ovarian cancer. Molecular cancer therapeutics\| PubMed ID: 21551263	2011
Hydrogels Containing Core Cross-Linked Block Co-Polymer Micelles. Journal of biomaterials science. Polymer edition\| PubMed ID: 21619728	2012
APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21640146	2011
Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 21669300	2012
Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21982897	2012
An injectable depot system for sustained intraperitoneal chemotherapy of ovarian cancer results in favorable drug distribution at the whole body, peritoneal and intratumoral levels. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22154933	2012
Block copolymer micelles target Auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells. Biomacromolecules\| PubMed ID: 22191486	2012
Recent advances in drug delivery strategies for treatment of ovarian cancer. Expert opinion on drug delivery\| PubMed ID: 22452661	2012
Neurologic withdrawal symptoms following abrupt discontinuation of a prolonged dexmedetomidine infusion in a child. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG\| PubMed ID: 22477791	2010
Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22588260	2012
Neoplastic cell response to tiopronin-coated gold nanoparticles. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22687897	2013
Hydrogel containing silica shell cross-linked micelles for ocular drug delivery. Journal of pharmaceutical sciences\| PubMed ID: 23203974	2012
Comparison of computed tomography- and optical image-based assessment of liposome distribution. Molecular imaging\| PubMed ID: 23490441	2013
Multicellular tumor spheroids for evaluation of cytotoxicity and tumor growth inhibitory effects of nanomedicines in vitro: a comparison of docetaxel-loaded block copolymer micelles and Taxo... PloS one\| PubMed ID: 23626842	2013
Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. PloS one\| PubMed ID: 23717534	2013
A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies. PloS one\| PubMed ID: 23840673	2013
Thermosensitive depot-forming injectable phosphatidylcholine blends tailored for localized drug delivery. Journal of pharmaceutical sciences\| PubMed ID: 23873505	2013
Continuous intraperitoneal carboplatin delivery for the treatment of late-stage ovarian cancer. Molecular pharmaceutics\| PubMed ID: 23924289	2013
Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24021358	2013
Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xe... Molecular pharmaceutics\| PubMed ID: 24066900	2013
The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice. Psychopharmacology\| PubMed ID: 24101158	2014
Multi-arm PEG/silica hydrogel for sustained ocular drug delivery. Journal of pharmaceutical sciences\| PubMed ID: 24285503	2014
A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors. PloS one\| PubMed ID: 24312530	2013
Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts. International journal of pharmaceutics\| PubMed ID: 24440400	2014
Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24440663	2014
Expression of membrane transporters and metabolic enzymes involved in estrone-3-sulphate disposition in human breast tumour tissues. Breast cancer research and treatment\| PubMed ID: 24831777	2014
The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation. Advanced drug delivery reviews\| PubMed ID: 25308250	2015
Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells. Radiation research\| PubMed ID: 25361396	2014
(125)I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells. Nuclear medicine and biology\| PubMed ID: 25542669	2015
Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25862513	2015
Development of a liposome formulation for improved biodistribution and tumor accumulation of pentamidine for oncology applications. International journal of pharmaceutics\| PubMed ID: 25910415	2015
The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26070245	2015
The Global Burden of Cancer 2013. JAMA oncology\| PubMed ID: 26181261	2015
A multimodal nano agent for image-guided cancer surgery. Biomaterials\| PubMed ID: 26218742	2015
Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease. Molecular pharmaceutics\| PubMed ID: 26394060	2015
Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26403800	2015
Preclinical imaging and translational animal models of cancer for accelerated clinical implementation of nanotechnologies and macromolecular agents. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26409122	2015
592: VANCOMYCIN DOSING AND PHARMACOKINETICS IN POSTOPERATIVE PEDIATRIC CARDIOTHORACIC SURGERY PATIENTS. Critical care medicine\| PubMed ID: 26570253	2015
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements. Advanced drug delivery reviews\| PubMed ID: 26712711	2015
Vancomycin Dosing and Pharmacokinetics in Postoperative Pediatric Cardiothoracic Surgery Patients. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG\| PubMed ID: 26997930	2016
Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer. Radiation research\| PubMed ID: 27135970	2016
Thermosensitive liposomal cisplatin in combination with local hyperthermia results in tumor growth delay and changes in tumor microenvironment in xenograft models of lung carcinoma. Journal of drug targeting\| PubMed ID: 27310112	2016
Why I'm Holding onto Hope for Nano in Oncology. Molecular pharmaceutics\| PubMed ID: 27404330	2016
The burden of cancer in Mexico, 1990-2013. Salud pública de México\| PubMed ID: 27557370	2016