A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Department of Medical Biophysics,University of Toronto, 2Leslie Dan Faculty of Pharmacy,University of Toronto, 3STTARR Innovation Centre,Princess Margaret Cancer Centre, 4Institute of Biomaterials and Biomedical Engineering,University of Toronto, 5Techna Institute,University Health Network, 6Radiation Medicine Program,Princess Margaret Cancer Centre
Chapters
- 00:05Title
- 00:52Tumor Microcirculation and Computed Tomography (CT)-liposome Distribution CT Imaging
- 04:43Tumor Interstitial Fluid Pressure (IFP) Spatial Measurement
- 06:41Results: Representative CT-liposome Imaging
- 08:18Conclusion
The heterogeneous intra-tumoral accumulation of liposomes has been linked to an abnormal tumor microenvironment. Herein methods are presented to measure tumor microcirculation by perfusion imaging and elevated interstitial fluid pressure (IFP) using an image-guided robotic system. Measurements are compared to the intra-tumoral accumulation of liposomes, determined using volumetric micro-CT imaging.
