Susanna Brighenti

Susanna Brighenti

Department of Medicine, Karolinska Institute

Affiliated withKarolinska InstituteKarolinska Institutet

Research Area

Biography

Susanna Brighenti is an Associate Professor in Immunology at the Center for Infectious Medicine (CIM) at Karolinska Institutet (KI) in Stockholm, Sweden. Her research group study immunopathogenesis in human tuberculosis (TB) infection with the aim to develop new host-directed therapies for difficult-to-treat TB disease such as multidrug-resistant TB (MDR-TB).

Dr. Brighenti performed her PhD training at Lund University and Active Biotech Research (1997-2002) before she was recruited to Karolinska Institutet as a postdoctoral fellow (2003-2008). Since 2008, Dr. Brighenti is one out of 15 group leaders at CIM, which is part of a new research environment, ANA Futura at KI Campus Flemingsberg, with shared infrastructure and cooperation for translational research and education and in close interaction with the Karolinska University hospital.

Dr. Brighenti´s group uses a combination of clinical and translational studies of immune responses in TB patients and including assessment of samples from peripheral blood, fluids and tissue samples, and in vitro studies of immune responses in TB using a macrophage infection model and different Mycobacterium tuberculosis strains. The group has extensive collaborations with TB-endemic countries such as Ethiopia and Bangladesh, where some of the key concepts for host-directed therapies have been tested in randomized clinical trials.

JoVE Journal Publications

ArticleTotal : 2
Year
A 3D Human Lung Tissue Model for Functional Studies on <em>Mycobacterium tuberculosis</em> Infection
Publication title

Cited by 40

2015
2020

Other Publications

Article
Year
Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions.

The American journal of pathology| PubMed ID: 19435796

2009
Induction and regulation of CD8+ cytolytic T cells in human tuberculosis and HIV infection.

Biochemical and biophysical research communications| PubMed ID: 20494110

2010
2011
2012
2012
Local immune responses in human tuberculosis: learning from the site of infection.

The Journal of infectious diseases| PubMed ID: 22448014

2012
2013
2014
2014
2015
2015
2015
B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America| PubMed ID: 26409285

2015
Regulation of Immunity to Tuberculosis.

Microbiology spectrum| PubMed ID: 28087948

2016
Humoral immune profiling of mycobacterial antigen recognition in sarcoidosis and Löfgren's syndrome using high-content peptide microarrays.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases| PubMed ID: 28159576

2017
Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-Guérin vaccination.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases| PubMed ID: 28161459

2017
2017
IL-7δ5 protein is expressed in human tissues and induces expression of the oxidized low density lipoprotein receptor 1 (OLR1) in CD14+ monocytes.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases| PubMed ID: 28279736

2017
2018
Prostaglandin E suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 29401596

2018
2018
Friends and foes of tuberculosis: modulation of protective immunity.

Journal of internal medicine| PubMed ID: 29804292

2018
2018
2019
2019
2019
Targeted Nutrition in Chronic Disease.

Nutrients| PubMed ID: 32516882

2020