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Journal / Immunology and Infection / A 3D Human Lung Tissue Model for Functional…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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Journal (Immunology and Infection)
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Journal (Immunology and Infection)
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Article DOI: 10.3791/53084 • 10:10 min • October 5th, 2015
October 5th, 2015 •
1, 2, 2, 1, 1,2
1Department of Clinical and Experimental Medicine, Linköping University, 2Department of Medicine, Karolinska Institute

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Summary
Automatic Translation

Human tuberculosis infection is a complex process, which is difficult to model in vitro. Here we describe a novel 3D human lung tissue model that recapitulates the dynamics that occur during infection, including the migration of immune cells and early granuloma formation in a physiological environment.

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3D Human Lung Tissue Model Mycobacterium Tuberculosis Infection Tuberculosis In Vitro Model Disease Mechanisms Treatment Options Epithelial Cells Fibroblasts Collagen Matrix Porous Membrane Mucus Secretion Primary Macrophages TB Granuloma Organotypic Culture Method Host Cell-pathogen Interactions
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