cell-labeling-targeting-with-superparamagnetic-iron-oxide

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Targeted delivery of cells and therapeutic agents would benefit a wide range of biomedical applications by concentrating the therapeutic effect at the ...

Masaryk Memorial Cancer Institute

[Potential clinical benefit of therapeutic drug monitoring of imatinib in oncology].

Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven to induce proliferation and tube formation in endothelial cells, stabilise contacts between endothelial cells, and mediate pericyte recruitment. Since apelin level is reduced early after myocardial infarction, a supportive therapy with apelin is being investigated for its beneficial effect on blood vessel formation. It is becoming apparent, however, that the final effect of apelin often depends on stimuli the cell receives and the cross-talk with other molecules inside the cell. Hence, understanding the apelin pathway potentially can help us to improve angiogenic therapy. This review summarises recent knowledge regarding molecules involved in apelin signalling while focusing on their roles in angiogenesis within the ischemic environment after myocardial infarction.

Article	Year
[Potential clinical benefit of therapeutic drug monitoring of imatinib in oncology]. Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti\| PubMed ID: 25997207	2015
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia. Vascular pharmacology\| PubMed ID: 26254105	2015

Martin Klabusay

Biography

JoVE Journal Publications

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