Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Brandon J. Tefft; Susheil Uthamaraj; J. Jonathan Harburn; Martin Klabusay; Dan Dragomir-Daescu; Gurpreet S. Sandhu

doi:10.3791/53099

Journal

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Bioengineering

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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

11,979 Views

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08:26 min

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October 19, 2015

DOI:

10.3791/53099-v

DOI:

10.3791/53099-v

•

08:26 min

October 19, 2015

•

1 Views

Brandon J. Tefft¹, Susheil Uthamaraj², J. Jonathan Harburn³, Martin Klabusay⁴, Dan Dragomir-Daescu^2,5, Gurpreet S. Sandhu¹

¹Division of Cardiovascular Diseases,Mayo Clinic, ²Division of Engineering,Mayo Clinic, ³School of Medicine, Pharmacy and Health,Durham University, ⁴Regional Center for Applied Molecular Oncology,Masaryk Memorial Cancer Institute, ⁵Mayo Clinic College of Medicine, Mayo Clinic

Summary

Targeted cell delivery is useful in a variety of biomedical applications. The goal of this protocol is to use superparamagnetic iron oxide nanoparticles (SPION) to label cells and thereby enable magnetic cell targeting approaches for a high degree of control over cell delivery and localization.