Geert Jan Biessels

Department of Neurology, University Medical Center Utrecht

Affiliated withUniversity Medical Center Utrecht Utrecht University

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 24	2015
Publication title Cited by 30	2019

Other Publications

Article	Year
Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial disease--Magnetic Resonance (SMART-MR) study. Neurobiology of aging\| PubMed ID: 23932882	2014
Ageing and diabetes: implications for brain function. European journal of pharmacology\| PubMed ID: 12007915	2002
Neuronal Ca2+ disregulation in diabetes mellitus. European journal of pharmacology\| PubMed ID: 12151012	2002
Effects of a phorbol ester and cyclosporin A on hippocampal synaptic plasticity in streptozotocin-induced-diabetic rats: reduced sensitivity to phorbol esters. Neuroscience letters\| PubMed ID: 12618297	2003
Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats. Brain research\| PubMed ID: 12618350	2003
Nerve conduction velocity and evoked potential latencies in streptozotocin-diabetic rats: effects of treatment with an angiotensin converting enzyme inhibitor. Diabetes/metabolism research and reviews\| PubMed ID: 14648806	2003
Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface. European journal of pharmacology\| PubMed ID: 15094068	2004
Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels. European journal of pharmacology\| PubMed ID: 15094082	2004
Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats. Brain research\| PubMed ID: 15713280	2005
The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes care\| PubMed ID: 15735218	2005
The effect of short duration streptozotocin-induced diabetes mellitus on the late phase and threshold of long-term potentiation induction in the rat. Brain research\| PubMed ID: 16038887	2005
The impact of diabetes on cognition: what can be learned from rodent models? Neurobiology of aging\| PubMed ID: 16223548	2005
Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic. Journal of neurology\| PubMed ID: 16283097	2006
Risk of dementia in diabetes mellitus: a systematic review. The Lancet. Neurology\| PubMed ID: 16361024	2006
Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats. Brain research\| PubMed ID: 16455062	2006
Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat. Life sciences\| PubMed ID: 16504211	2006
Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes\| PubMed ID: 16567535	2006
Cognitive performance, psychological well-being, and brain magnetic resonance imaging in older patients with type 1 diabetes. Diabetes\| PubMed ID: 16731845	2006
Brain imaging in patients with diabetes: a systematic review. Diabetes care\| PubMed ID: 17065699	2006
A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus. Journal of the International Neuropsychological Society : JINS\| PubMed ID: 17286886	2007
Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study. Dementia and geriatric cognitive disorders\| PubMed ID: 17374953	2007
Cognition and diabetes: a lifespan perspective. The Lancet. Neurology\| PubMed ID: 18207116	2008
Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease. Stroke; a journal of cerebral circulation\| PubMed ID: 18369167	2008
Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. European journal of pharmacology\| PubMed ID: 18395201	2008
Structural brain imaging in diabetes: a methodological perspective. European journal of pharmacology\| PubMed ID: 18407264	2008
Cognitive dysfunction and diabetes: implications for primary care. Primary care diabetes\| PubMed ID: 18632044	2007
Construction of periventricular white matter hyperintensity maps by spatial normalization of the lateral ventricles. Human brain mapping\| PubMed ID: 18830954	2009
Cognitive functioning in elderly persons with type 2 diabetes and metabolic syndrome: the Hoorn study. Dementia and geriatric cognitive disorders\| PubMed ID: 18841011	2008
Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition. Biochimica et biophysica acta\| PubMed ID: 18848880	2009
Cognition in the early stage of type 2 diabetes. Diabetes care\| PubMed ID: 19366968	2009
Hyperglycemia and clinical outcome in aneurysmal subarachnoid hemorrhage: a meta-analysis. Stroke; a journal of cerebral circulation\| PubMed ID: 19390078	2009
White matter lesions and brain atrophy: more than shared risk factors? A systematic review. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 19571536	2009
Diabetes: hypoglycemia and dementia in type 2 diabetes: chick or egg? Nature reviews. Endocrinology\| PubMed ID: 19763124	2009
Blood pressure levels in pre-diabetic stages are associated with worse cognitive functioning in patients with type 2 diabetes. Diabetes/metabolism research and reviews\| PubMed ID: 19768735	2009
MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance. Neuroradiology\| PubMed ID: 19789860	2010
Ten-year time course of risk factors for increased carotid intima-media thickness: the Hoorn Study. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology\| PubMed ID: 19940777	2010
Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management. Nature reviews. Neurology\| PubMed ID: 20157308	2010
Caffeine, diabetes, cognition, and dementia. Journal of Alzheimer's disease : JAD\| PubMed ID: 20182038	2010
Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes. Diabetes care\| PubMed ID: 20299484	2010
Glycemia and levels of cerebrospinal fluid amyloid and tau in patients attending a memory clinic. Journal of the American Geriatrics Society\| PubMed ID: 20487079	2010
Visualization of cerebral microbleeds with dual-echo T2*-weighted magnetic resonance imaging at 7.0 T. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 20578010	2010
Hyperglycemia in aneurysmal subarachnoid hemorrhage: a potentially modifiable risk factor for poor outcome. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20628402	2010
Perfusion CT in suspected ischaemic stroke: red flags that should have been blue. Journal of neurology\| PubMed ID: 20703886	2011
Cognitive dysfunction in patients with type 2 diabetes. Diabetes/metabolism research and reviews\| PubMed ID: 20799243	2010
No evidence of microbleeds in ALS patients at 7 Tesla MRI. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases\| PubMed ID: 20812888	2010
Cerebral cortical thickness in patients with type 2 diabetes. Journal of the neurological sciences\| PubMed ID: 20869085	2010
A comparison of MR based segmentation methods for measuring brain atrophy progression. NeuroImage\| PubMed ID: 20888923	2011
Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes. Dementia and geriatric cognitive disorders\| PubMed ID: 20962529	2010
Should we target insulin resistance to prevent dementia due to Alzheimer disease? Archives of neurology\| PubMed ID: 21220672	2011
Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors. Diabetes/metabolism research and reviews\| PubMed ID: 21294241	2011
Vascular risk scores for dementia: age matters. Archives of neurology\| PubMed ID: 21320999	2011
Cognition in older patients with type 1 diabetes mellitus: a longitudinal study. Journal of the American Geriatrics Society\| PubMed ID: 21391954	2011
Intensive insulin therapy increases the risk of hypoglycemia in neurocritical care patients. Journal of neurosurgical anesthesiology\| PubMed ID: 21593693	2011
Diabetic Polyneuropathies: Update on Research Definition, Diagnostic Criteria and Estimation of Severity. Diabetes/metabolism research and reviews\| PubMed ID: 21695763	2011
Intracranial vessel wall imaging at 7.0-T MRI. Stroke; a journal of cerebral circulation\| PubMed ID: 21757674	2011
Intensive glucose lowering and cognition in type 2 diabetes. The Lancet. Neurology\| PubMed ID: 21958948	2011
The metabolic syndrome, atherosclerosis and cognitive functioning in a non-demented population: the Hoorn Study. Atherosclerosis\| PubMed ID: 21959256	2011
Efficient detection of cerebral microbleeds on 7.0 T MR images using the radial symmetry transform. NeuroImage\| PubMed ID: 21985903	2012
Heart failure and cognitive function in the general population: the Hoorn Study. European journal of heart failure\| PubMed ID: 21990341	2011
Intensive multifactorial treatment and cognitive functioning in screen-detected type 2 diabetes--the ADDITION-Netherlands study: a cluster-randomized trial. Journal of the neurological sciences\| PubMed ID: 22093142	2012
Effect of chronic intracerebroventricular insulin administration in rats on the peripheral glucose metabolism and synaptic plasticity of CA1 hippocampal neurons. Brain research\| PubMed ID: 22206925	2012
Cerebral microinfarcts: a systematic review of neuropathological studies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22234334	2012
Diabetes, hyperglycaemia, and acute ischaemic stroke. The Lancet. Neurology\| PubMed ID: 22341034	2012
The Telephone Interview for Cognitive Status (Modified): relation with a comprehensive neuropsychological assessment. Journal of clinical and experimental neuropsychology\| PubMed ID: 22384819	2012
Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes. Journal of diabetes and its complications\| PubMed ID: 22520398	2012
High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 22531417	2012
Mild depressive symptoms do not influence cognitive functioning in patients with type 2 diabetes. Psychoneuroendocrinology\| PubMed ID: 22818834	2013
Unraveling the puzzle of dementia risk in diabetes. Journal of diabetes and its complications\| PubMed ID: 22832376	2012
Development of vascular risk factors over 15 years in relation to cognition: the Hoorn Study. Journal of the American Geriatrics Society\| PubMed ID: 22861348	2012
Quantification of cerebral volumes on MRI 6 months after aneurysmal subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 22933584	2012
Improved sensitivity to cerebral white matter abnormalities in Alzheimer's disease with spherical deconvolution based tractography. PloS one\| PubMed ID: 22952880	2012
Microstructural white matter abnormalities and cognitive functioning in type 2 diabetes: a diffusion tensor imaging study. Diabetes care\| PubMed ID: 22961577	2013
In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23250109	2013
Disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes. Diabetes\| PubMed ID: 23349494	2013
Dysglycemia, brain volume and vascular lesions on MRI in a memory clinic population. Journal of diabetes and its complications\| PubMed ID: 23352495	2014
Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms. Experimental brain research\| PubMed ID: 23371746	2013
Admission hyperglycaemia and cerebral perfusion deficits in acute ischaemic stroke. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 23429063	2013
Cerebral microinfarcts: Enumerating the innumerable. Neurology\| PubMed ID: 23486874	2013
Disruption of cerebral networks and cognitive impairment in Alzheimer disease. Neurology\| PubMed ID: 23486876	2013
Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls. Neurobiology of aging\| PubMed ID: 23522844	2013
The "Test Your Memory" test performs better than the MMSE in a population without known cognitive dysfunction. Journal of the neurological sciences\| PubMed ID: 23531478	2013
Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23591648	2013
The effect of lacunar infarcts on white matter tract integrity. Stroke; a journal of cerebral circulation\| PubMed ID: 23686971	2013
Semi-Automated Detection of Cerebral Microbleeds on 3.0 T MR Images. PloS one\| PubMed ID: 23805246	2013
Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study. Journal of the neurological sciences\| PubMed ID: 23835088	2013
Sweet memories: 20 years of progress in research on cognitive functioning in diabetes. European journal of pharmacology\| PubMed ID: 23872409	2013
Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 23948936	2014
Midlife risk score for the prediction of dementia four decades later. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 24035147	2014
Reliability of visual assessment of non-contrast CT, CT angiography source images and CT perfusion in patients with suspected ischemic stroke. PloS one\| PubMed ID: 24116061	2013
Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 24121967	2014
How to assess the reliability of cerebral microbleed rating? Frontiers in aging neuroscience\| PubMed ID: 24133445	2013
Hippocampal T2 hyperintensities on 7 Tesla MRI. NeuroImage. Clinical\| PubMed ID: 24179863	2013
Brain MRI correlates of cognitive dysfunction in type 2 diabetes: the needle recovered from the haystack? Diabetes care\| PubMed ID: 24265363	2013
Automatic extraction of the midsagittal surface from brain MR Images using the Kullback-Leibler measure. Neuroinformatics\| PubMed ID: 24338727	2014
Brain MRI in children with type 1 diabetes: snapshot or road map of developmental changes? Diabetes\| PubMed ID: 24357700	2014
Visualization of perivascular spaces and perforating arteries with 7 T magnetic resonance imaging. Investigative radiology\| PubMed ID: 24473365	2014
Symptom Checklist 90-Revised in neurological outpatients. Journal of clinical and experimental neuropsychology\| PubMed ID: 24479727	2014
Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains. Journal of the International Neuropsychological Society : JINS\| PubMed ID: 24555960	2014
Cerebral microbleeds are not associated with long-term cognitive outcome in patients with transient ischemic attack or minor stroke. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 24557016	2014
Prediction of outcome in patients with suspected acute ischaemic stroke with CT perfusion and CT angiography: the Dutch acute stroke trial (DUST) study protocol. BMC neurology\| PubMed ID: 24568540	2014
Outcome markers for clinical trials in cerebral amyloid angiopathy. The Lancet. Neurology\| PubMed ID: 24581702	2014
Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study. The lancet. Diabetes & endocrinology\| PubMed ID: 24622366	2013
Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. The lancet. Diabetes & endocrinology\| PubMed ID: 24622755	2014
Severe diabetic retinal disease and dementia risk in type 2 diabetes. Journal of Alzheimer's disease : JAD\| PubMed ID: 24625797	2014
Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging. Neurobiology of aging\| PubMed ID: 24684788	2014
Brain imaging in type 2 diabetes. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 24726582	2014
High resolution imaging of cerebral small vessel disease with 7 T MRI. Acta neurochirurgica. Supplement\| PubMed ID: 24728645	2014
Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 24756079	2014
Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes. Diabetes\| PubMed ID: 24760137	2014
Vascular retinopathy in relation to cognitive functioning in an older population--the Hoorn Study. Journal of the American Geriatrics Society\| PubMed ID: 24828928	2014
Developing biomarkers for cerebral amyloid angiopathy trials: do potential disease phenotypes hold promise? - authors' reply. The Lancet. Neurology\| PubMed ID: 24849857	2014
Absolute and relative temporal order memory for performed activities following stroke. Journal of clinical and experimental neuropsychology\| PubMed ID: 24925480	2014
Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes\| PubMed ID: 24931032	2014
Global brain atrophy but not hippocampal atrophy is related to type 2 diabetes. Journal of the neurological sciences\| PubMed ID: 24958596	2014
Capitalising on modifiable risk factors for Alzheimer's disease. The Lancet. Neurology\| PubMed ID: 25030506	2014
The anatomy of visuospatial construction revealed by lesion-symptom mapping. Neuropsychologia\| PubMed ID: 25062545	2014
Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. The lancet. Diabetes & endocrinology\| PubMed ID: 25163604	2015
Ischaemic cavities in the cerebellum: an ex vivo 7-tesla MRI study with pathological correlation. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 25171512	2014
The heart-brain connection: a multidisciplinary approach targeting a missing link in the pathophysiology of vascular cognitive impairment. Journal of Alzheimer's disease : JAD\| PubMed ID: 25213769	2014
A Critical Appraisal of the Hippocampal Subfield Segmentation Package in FreeSurfer. Frontiers in aging neuroscience\| PubMed ID: 25309437	2014
FLAIR images at 7 Tesla MRI highlight the ependyma and the outer layers of the cerebral cortex. NeuroImage\| PubMed ID: 25315783	2015
Bayesian model selection for pathological data. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 25333134	2014
Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy. Brain : a journal of neurology\| PubMed ID: 25367025	2015
Cognitive disorders in diabetic patients. Handbook of clinical neurology\| PubMed ID: 25410220	2014
Distinct anatomical correlates of discriminability and criterion setting in verbal recognition memory revealed by lesion-symptom mapping. Human brain mapping\| PubMed ID: 25423892	2015
Cortical microinfarcts detected in vivo on 3 Tesla MRI: clinical and radiological correlates. Stroke; a journal of cerebral circulation\| PubMed ID: 25468879	2015
Quantification of structural cerebral abnormalities on MRI 18 months after aneurysmal subarachnoid hemorrhage in patients who received endovascular treatment. Neuroradiology\| PubMed ID: 25479962	2015
Residual high-grade stenosis after recanalization of extracranial carotid occlusion in acute ischemic stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 25492908	2015
The Dutch Parelsnoer Institute--Neurodegenerative diseases; methods, design and baseline results. BMC neurology\| PubMed ID: 25551191	2014
Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI. European radiology\| PubMed ID: 25577517	2015
The spectrum of MR detectable cortical microinfarcts: a classification study with 7-tesla postmortem MRI and histopathology. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 25605293	2015
Hippocampal disconnection in early Alzheimer's disease: a 7 tesla MRI study. Journal of Alzheimer's disease : JAD\| PubMed ID: 25697703	2015
Relation between stroke severity, patient characteristics and CT-perfusion derived blood-brain barrier permeability measurements in acute ischemic stroke. Clinical neuroradiology\| PubMed ID: 25722019	2015
Cognitive function in patients with diabetes mellitus: guidance for daily care. The Lancet. Neurology\| PubMed ID: 25728442	2015
The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis. Journal of the neurological sciences\| PubMed ID: 25748296	2015
7Tesla vessel wall imaging of the basilar artery in perimesencephalic hemorrhage. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 25777838	2015
Bayesian Model Selection for Pathological Neuroimaging Data Applied to White Matter Lesion Segmentation. IEEE transactions on medical imaging\| PubMed ID: 25850086	2015
Shared and distinct anatomical correlates of semantic and phonemic fluency revealed by lesion-symptom mapping in patients with ischemic stroke. Brain structure & function\| PubMed ID: 25939335	2015
Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 25956990	2015
Acute nephropathy after contrast agent administration for computed tomography perfusion and computed tomography angiography in patients with acute ischemic stroke. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 25973707	2015
Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer's dementia. Journal of clinical and experimental neuropsychology\| PubMed ID: 26011711	2015
Brain changes in T1DM--a microvascular complication? Nature reviews. Endocrinology\| PubMed ID: 26055044	2015
Cognitive Impairment in Diabetes: Rationale and Design Protocol of the Cog-ID Study. JMIR research protocols\| PubMed ID: 26058427	2015
Cortical microinfarcts on 7 T MRI in patients with spontaneous intracerebral hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26122138	2015
Undiagnosed cognitive impairment, health status and depressive symptoms in patients with type 2 diabetes. Journal of diabetes and its complications\| PubMed ID: 26281970	2015
Completeness of the circle of Willis and risk of ischemic stroke in patients without cerebrovascular disease. Neuroradiology\| PubMed ID: 26358136	2015
Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease. Neurobiology of aging\| PubMed ID: 26410308	2015
Hippocampal insulin resistance and cognitive dysfunction. Nature reviews. Neuroscience\| PubMed ID: 26462756	2015
The Prognostic Value of CT Angiography and CT Perfusion in Acute Ischemic Stroke. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 26484857	2015