Robert A. Screaton

Sunnybrook Research Institute, University of Toronto

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2015

Other Publications

Article	Year
Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia (New York, N.Y.)\| PubMed ID: 11896570	2002
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12702765	2003
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes & development\| PubMed ID: 12842910	2003
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell\| PubMed ID: 15454081	2004
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature\| PubMed ID: 16148943	2005
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18626018	2008
The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell metabolism\| PubMed ID: 18762022	2008
Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19098422	2008
Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators. The Journal of biological chemistry\| PubMed ID: 19473990	2009
A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation. EMBO reports\| PubMed ID: 19713961	2009
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell metabolism\| PubMed ID: 19808021	2009
Depletion of intranuclear rodlets in mouse models of diabetes. Endocrine pathology\| PubMed ID: 20922502	2010
Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels. Cellular signalling\| PubMed ID: 20940047	2011
Role of AMPK in pancreatic beta cell function. Molecular and cellular endocrinology\| PubMed ID: 22766107	2013
Glucose metabolism and pancreatic defects in spinal muscular atrophy. Annals of neurology\| PubMed ID: 22926856	2012
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Human molecular genetics\| PubMed ID: 23187960	2013
CRTC2 is required for β-cell function and proliferation. Endocrinology\| PubMed ID: 23677932	2013
Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy. Autophagy\| PubMed ID: 24005319	2013
ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics. Science signaling\| PubMed ID: 24473195	2014
Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity. Molecular and cellular biology\| PubMed ID: 24492964	2014
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Nature cell biology\| PubMed ID: 24561619	2014
SGK1: master and commander of the fate of helper T cells. Nature immunology\| PubMed ID: 24747705	2014
Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion. Molecular and cellular biology\| PubMed ID: 25332238	2015
High-content functional genomic screening to identify novel regulators of the PINK1-Parkin pathway. Methods in enzymology\| PubMed ID: 25416349	2014
LKB1 couples glucose metabolism to insulin secretion in mice. Diabetologia\| PubMed ID: 25874445	2015
Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy. Human molecular genetics\| PubMed ID: 26085578	2015
To Be(ta Cell) or Not to Be(ta cell): New Mouse Models for Studying Gene Function in the Pancreatic β-Cell. Endocrinology\| PubMed ID: 26091426	2015
Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone. Diabetes\| PubMed ID: 26153246	2015