Johannes B. Huppa

Institute for Hygiene and Applied Immunology, Medical University of Vienna

Affiliated withMedical University of Vienna

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 9	2015
Publication title Cited by 16	2015
Publication title Cited by 7	2021

Other Publications

Article	Year
Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nature immunology\| PubMed ID: 12858171	2003
Dynamics of cell surface molecules during T cell recognition. Annual review of biochemistry\| PubMed ID: 14527326	2003
T-cell-antigen recognition and the immunological synapse. Nature reviews. Immunology\| PubMed ID: 14647479	2003
Linking molecular and cellular events in T-cell activation and synapse formation. Seminars in immunology\| PubMed ID: 15001169	2003
T cell killing does not require the formation of a stable mature immunological synapse. Nature immunology\| PubMed ID: 15048111	2004
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nature immunology\| PubMed ID: 15247914	2004
Quantitative imaging of lymphocyte membrane protein reorganization and signaling. Biophysical journal\| PubMed ID: 15501943	2005
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature\| PubMed ID: 15724150	2005
A hybrid machine-learning approach for segmentation of protein localization data. Bioinformatics (Oxford, England)\| PubMed ID: 16091410	2005
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nature immunology\| PubMed ID: 20010844	2010
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature\| PubMed ID: 20164930	2010
Evidence for a functional sidedness to the alphabetaTCR. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20202921	2010
Functional development of the T cell receptor for antigen. Progress in molecular biology and translational science\| PubMed ID: 20800817	2010
Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC. Nature immunology\| PubMed ID: 22660579	2012
Determination of interaction kinetics between the T cell receptor and peptide-loaded MHC class II via single-molecule diffusion measurements. Biophysical journal\| PubMed ID: 22853916	2012
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nature immunology\| PubMed ID: 23377202	2013
The interdisciplinary science of T-cell recognition. Advances in immunology\| PubMed ID: 23886063	2013
Rapid multiplex analysis of lipid raft components with single-cell resolution. Science signaling\| PubMed ID: 26396269	2015
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1. Journal of immunological methods\| PubMed ID: 26780292	2016
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nature immunology\| PubMed ID: 27776107	2016
Förster Resonance Energy Transfer to Study TCR-pMHC Interactions in the Immunological Synapse. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28255705	2017
A cellular platform for the evaluation of immune checkpoint molecules. Oncotarget\| PubMed ID: 29029399	2017
Monomeric TCRs drive T cell antigen recognition. Nature immunology\| PubMed ID: 29662172	2018
Mutations affecting the actin regulator WD repeat-containing protein 1 lead to aberrant lymphoid immunity. The Journal of allergy and clinical immunology\| PubMed ID: 29751004	2018
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Frontiers in immunology\| PubMed ID: 29780382	2018
TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells. Nature immunology\| PubMed ID: 30013143	2018
How drag sharpens a T cell's view on antigen. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31371492	2019
Homo- and Heteroassociations Drive Activation of ErbB3. Biophysical journal\| PubMed ID: 31653451	2019
Getting CD19 Into Shape: Expression of Natively Folded "Difficult-to- Express" CD19 for Staining and Stimulation of CAR-T Cells. Frontiers in bioengineering and biotechnology\| PubMed ID: 32117929	2020
TIM-3 and CEACAM1 do not interact in cis and in trans. European journal of immunology\| PubMed ID: 32222966	2020
Inefficient CAR-proximal signaling blunts antigen sensitivity. Nature immunology\| PubMed ID: 32632291	2020
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science immunology\| PubMed ID: 32646852	2020
Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Nature communications\| PubMed ID: 32820173	2020
Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy. Nature communications\| PubMed ID: 33020470	2020
Functionalized Bead Assay to Measure Three-dimensional Traction Forces during T-cell Activation. Nano letters\| PubMed ID: 33305952	2021
DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33468643	2021
A Multimodal Platform for Simultaneous T-Cell Imaging, Defined Activation, and Mechanobiological Characterization. Cells\| PubMed ID: 33504075	2021
Histone deacetylase 1 controls CD4 T cell trafficking in autoinflammatory diseases. Journal of autoimmunity\| PubMed ID: 33621930	2021
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 T cell responses. Science immunology\| PubMed ID: 33664060	2021
Adjuvants and Vaccines Used in Allergen-Specific Immunotherapy Induce Neutrophil Extracellular Traps. Vaccines\| PubMed ID: 33915724	2021
Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements. Nature communications\| PubMed ID: 33947864	2021
Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus. Frontiers in immunology\| PubMed ID: 34194424	2021
Strategies for the Site-Specific Decoration of DNA Origami Nanostructures with Functionally Intact Proteins. ACS nano\| PubMed ID: 34463486	2021
Three-Dimensional Single Molecule Localization Microscopy Reveals the Topography of the Immunological Synapse at Isotropic Precision below 15 nm. Nano letters\| PubMed ID: 34709845	2021