Christopher Nicchitta

Department of Cell Biology, Duke University School of Medicine

Affiliated withDuke University School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2015

Other Publications

Article	Year
Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis. The Journal of biological chemistry\| PubMed ID: 11964406	2002
Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11970968	2002
GRP94-associated enzymatic activities. Resolution by chromatographic fractionation. The Journal of biological chemistry\| PubMed ID: 11983709	2002
A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. Current opinion in cell biology\| PubMed ID: 12383790	2002
GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. The Journal of experimental medicine\| PubMed ID: 12461080	2002
ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection. Current opinion in immunology\| PubMed ID: 12495739	2003
Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity. Nature reviews. Immunology\| PubMed ID: 12766764	2003
GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. The Journal of biological chemistry\| PubMed ID: 12805368	2003
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. RNA (New York, N.Y.)\| PubMed ID: 12923260	2003
Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression. The Journal of clinical investigation\| PubMed ID: 12952910	2003
Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. The Journal of biological chemistry\| PubMed ID: 12970348	2003
Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. The EMBO journal\| PubMed ID: 14609958	2003
Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15034032	2004
Adenosine nucleotides and the regulation of GRP94-client protein interactions. Biochemistry\| PubMed ID: 15236592	2004
The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity. Cell stress & chaperones\| PubMed ID: 15633290	2004
Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method. The journal of gene medicine\| PubMed ID: 15651066	2005
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. The Journal of biological chemistry\| PubMed ID: 15716279	2005
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Molecular cell\| PubMed ID: 15916966	2005
Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. Molecular biology of the cell\| PubMed ID: 16221886	2005
Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression. Cancer research\| PubMed ID: 16230366	2005
Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 16333319	2005
mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. RNA (New York, N.Y.)\| PubMed ID: 16540694	2006
Synthesis of Hsp90 dimerization modulators. Bioorganic & medicinal chemistry letters\| PubMed ID: 16621545	2006
Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. Protein science : a publication of the Protein Society\| PubMed ID: 16731965	2006
Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. The Journal of biological chemistry\| PubMed ID: 16754684	2006
The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends in immunology\| PubMed ID: 16815756	2006
In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum. Methods in enzymology\| PubMed ID: 17923230	2007
Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. Molecular biology of the cell\| PubMed ID: 18077556	2008
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. RNA (New York, N.Y.)\| PubMed ID: 18192611	2008
Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18369985	2008
Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology\| PubMed ID: 18489571	2008
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. Immunity\| PubMed ID: 18549799	2008
Cell biology: How to combat stress. Nature\| PubMed ID: 19194438	2009
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19342676	2009
Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19752220	2009
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress. Cancer research\| PubMed ID: 19920201	2009
Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Developmental biology\| PubMed ID: 20044986	2010
Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21048103	2010
Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21431749	2011
Out with the old, in with the new? Comparing methods for measuring protein degradation. Cell biology international\| PubMed ID: 21476986	2011
Polysome profiling of the malaria parasite Plasmodium falciparum. Molecular and biochemical parasitology\| PubMed ID: 21605599	2011
Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Molecular biology of the cell\| PubMed ID: 21613539	2011
Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. The Journal of biological chemistry\| PubMed ID: 22199352	2012
The enduring enigma of nuclear translation. The Journal of cell biology\| PubMed ID: 22472436	2012
Development of a Grp94 inhibitor. Journal of the American Chemical Society\| PubMed ID: 22642269	2012
Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. Arthritis and rheumatism\| PubMed ID: 22777994	2012
Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell host & microbe\| PubMed ID: 22901539	2012
Rare codons regulate KRas oncogenesis. Current biology : CB\| PubMed ID: 23246410	2013
Premature translational termination products are rapidly degraded substrates for MHC class I presentation. PloS one\| PubMed ID: 23251665	2012
Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PloS one\| PubMed ID: 24039668	2013
Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 25063809	2014
De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. RNA (New York, N.Y.)\| PubMed ID: 25142066	2014
The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell\| PubMed ID: 25215492	2014
A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. Genetics\| PubMed ID: 25316788	2014
Diversity and selectivity in mRNA translation on the endoplasmic reticulum. Nature reviews. Molecular cell biology\| PubMed ID: 25735911	2015
LOCAL TRANSLATION. Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling". Science (New York, N.Y.)\| PubMed ID: 26068841	2015
Simple and inexpensive ribosome profiling analysis of mRNA translation. Methods (San Diego, Calif.)\| PubMed ID: 26164698	2015