David Warburton

Saban Research Institute, Childrens Hospital Los Angeles

Affiliated withChildrens Hospital Los Angeles

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 32	2010

Other Publications

Article	Year
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 11839555	2002
Sound the tocsin! Beware adverse effects of lung inflammation early in gestation. American journal of respiratory and critical care medicine\| PubMed ID: 11897634	2002
Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling. Journal of pediatric surgery\| PubMed ID: 12149686	2002
Commentary on: "Effects of scopolamine and nicotine on human rapid information processing performance." Psychopharmacology (1984) 82:147-150. Nicotine improves information processing: saying... Psychopharmacology\| PubMed ID: 12172687	2002
Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse. Journal of pediatric surgery\| PubMed ID: 12194114	2002
Commentary on: "comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse." Psychopharmacologia (1968) ... Psychopharmacology\| PubMed ID: 12238442	2002
Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 12453143	2002
Nongenomic estrogen action regulates tyrosine phosphatase activity and tuberin stability. Molecular and cellular endocrinology\| PubMed ID: 12581886	2003
Fibrillin controls TGF-beta activation. Nature genetics\| PubMed ID: 12610545	2003
Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase. Pediatric research\| PubMed ID: 12761358	2003
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respiratory research\| PubMed ID: 12818006	2003
The influence of changing nicotine to tar ratios on human puffing behaviour and perceived sensory response. Psychopharmacology\| PubMed ID: 12904967	2003
Attribution and the effects of expectancy: how beliefs can influence the experiences of smoking cessation. Addictive behaviors\| PubMed ID: 12915176	2003
Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12922980	2004
TACE is required for fetal murine cardiac development and modeling. Developmental biology\| PubMed ID: 14499647	2003
Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. The American journal of pathology\| PubMed ID: 14633629	2003
Editorial note: MDMA-induced dopamine neurotoxicity. Psychopharmacology\| PubMed ID: 14634718	2004
Functional analysis of the human Sprouty2 gene promoter. Gene\| PubMed ID: 14644509	2003
Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 14711801	2004
Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 14977631	2004
The molecular genetics of lung morphogenesis and injury repair. Paediatric respiratory reviews\| PubMed ID: 14980285	2004
Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. Journal of pediatric surgery\| PubMed ID: 15017552	2004
Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. Journal of pediatric surgery\| PubMed ID: 15185216	2004
Knock-on effect of anthrax lethal toxin on macrophages potentiates cytotoxicity to endothelial cells. Microbes and infection / Institut Pasteur\| PubMed ID: 15374005	2004
Stem/progenitor cells in lung morphogenesis, repair, and regeneration. Current topics in developmental biology\| PubMed ID: 15563941	2004
Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15591413	2005
Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Developmental biology\| PubMed ID: 15617677	2005
Smad1 expression and function during mouse embryonic lung branching morphogenesis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15681399	2005
Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15743925	2005
Fibroblast growth factor-10 serves a regulatory role in duodenal development. Journal of pediatric surgery\| PubMed ID: 15750921	2005
Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. Journal of pediatric surgery\| PubMed ID: 15750935	2005
Molecular mechanisms of early lung specification and branching morphogenesis. Pediatric research\| PubMed ID: 15817505	2005
A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Developmental biology\| PubMed ID: 15950607	2005
Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity. The American journal of pathology\| PubMed ID: 16192627	2005
VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Developmental biology\| PubMed ID: 16375885	2006
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. Journal of pediatric surgery\| PubMed ID: 16410122	2006
Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Developmental biology\| PubMed ID: 16494859	2006
BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. The Journal of biological chemistry\| PubMed ID: 16880207	2006
Trace element concentrations and bioindicator responses in tree swallows from northwestern Minnesota. Environmental monitoring and assessment\| PubMed ID: 16897545	2006
Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Developmental biology\| PubMed ID: 16956603	2006
Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Developmental biology\| PubMed ID: 16989802	2006
Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 17014662	2006
Lung development and susceptibility to chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society\| PubMed ID: 17065371	2006
Smad3 signaling involved in pulmonary fibrosis and emphysema. Proceedings of the American Thoracic Society\| PubMed ID: 17065376	2006
Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea. Stem cells (Dayton, Ohio)\| PubMed ID: 17272495	2007
Water level management and contaminant exposure to tree swallows nesting on the Upper Mississippi River. Environmental monitoring and assessment\| PubMed ID: 17286172	2007
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene\| PubMed ID: 17350185	2007
Selenium and metal concentrations in waterbird eggs and chicks at Agassiz National Wildlife Refuge, Minnesota. Archives of environmental contamination and toxicology\| PubMed ID: 17464443	2007
Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. Journal of cellular physiology\| PubMed ID: 17516543	2007
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Developmental biology\| PubMed ID: 17560563	2007
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. The EMBO journal\| PubMed ID: 17673906	2007
Lung development and adult lung diseases. Chest\| PubMed ID: 17699136	2007
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. The international journal of biochemistry & cell biology\| PubMed ID: 17931953	2008
When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation? The Journal of physiology\| PubMed ID: 17932141	2007
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? The international journal of biochemistry & cell biology\| PubMed ID: 17936056	2008
Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway. Mechanisms of development\| PubMed ID: 18082381	2008
Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. The American journal of pathology\| PubMed ID: 18258849	2008
Centrifugal migration of mesenchymal cells in embryonic lung. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 18297731	2008
The human gamma-glutamyltransferase gene family. Human genetics\| PubMed ID: 18357469	2008
Developmental biology: order in the lung. Nature\| PubMed ID: 18528385	2008
Stem/progenitor cells in lung development, injury repair, and regeneration. Proceedings of the American Thoracic Society\| PubMed ID: 18684721	2008
Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha. Biochemical and biophysical research communications\| PubMed ID: 18713620	2008
Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem cells (Dayton, Ohio)\| PubMed ID: 18719226	2008
Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. The Journal of physiology\| PubMed ID: 18955379	2008
The 2nd International Collaborative Symposium on Stem Cell Research. Regenerative medicine\| PubMed ID: 19105622	2009
Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. The Journal of physiology\| PubMed ID: 19237431	2009
Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. American journal of respiratory and critical care medicine\| PubMed ID: 19498056	2009
miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Developmental biology\| PubMed ID: 19559694	2009
Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatric research\| PubMed ID: 19581825	2009
Development, repair and fibrosis: what is common and why it matters. Respirology (Carlton, Vic.)\| PubMed ID: 19659647	2009
Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Molecular and cellular biology\| PubMed ID: 19703997	2009
Genes and signals regulating murine trophoblast cell development. Mechanisms of development\| PubMed ID: 19755154	2010
O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis. The Journal of urology\| PubMed ID: 19914650	2010
A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. American journal of respiratory and critical care medicine\| PubMed ID: 19926868	2010
Introduction: Ninth Lund COPD Symposium. Proceedings of the American Thoracic Society\| PubMed ID: 19934348	2009
Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proceedings of the American Thoracic Society\| PubMed ID: 19934358	2009
Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. The Journal of urology\| PubMed ID: 20096867	2010
Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PloS one\| PubMed ID: 20195358	2010
Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenes... Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20204620	2010
On the derivation and clinical implications of "driver" mutations in lung cancer. American journal of respiratory and critical care medicine\| PubMed ID: 20463175	2010
Lung organogenesis. Current topics in developmental biology\| PubMed ID: 20691848	2010
Entrained pulmonary clocks: epithelium and vasculature keeping pace. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 20693313	2010
Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. American journal of respiratory cell and molecular biology\| PubMed ID: 20705941	2011
Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer biology & therapy\| PubMed ID: 21124074	2011
Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Developmental biology\| PubMed ID: 21129374	2011
FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development (Cambridge, England)\| PubMed ID: 21148187	2011
Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 21246661	2011
A modified technique for partial pneumonectomy in the mouse. Journal of investigative surgery : the official journal of the Academy of Surgical Research\| PubMed ID: 21345008	2011
Carbon monoxide pollution and lung function in urban compared with rural Mongolian children. Respirology (Carlton, Vic.)\| PubMed ID: 21362106	2011
Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Developmental biology\| PubMed ID: 21385574	2011
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development (Cambridge, England)\| PubMed ID: 21385765	2011
Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21460122	2011
A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways. Development (Cambridge, England)\| PubMed ID: 21558382	2011
Stem cells and cell therapies in lung biology and lung diseases. Proceedings of the American Thoracic Society\| PubMed ID: 21653527	2011
Mesenchymal-specific inhibition of vascular endothelial growth factor (VEGF) attenuates growth in neonatal mice. The Journal of surgical research\| PubMed ID: 21696760	2012
The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. American journal of respiratory cell and molecular biology\| PubMed ID: 21700959	2011
Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21743024	2011
Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PloS one\| PubMed ID: 21858009	2011
VEGF optimizes the formation of tissue-engineered small intestine. Regenerative medicine\| PubMed ID: 21916592	2011
Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain dependent manner. Endocrine-related cancer\| PubMed ID: 22167068	2011
Cell-based therapies for lung disease. British medical bulletin\| PubMed ID: 22279079	2012
MIR-99a and MIR-99b Modulate TGF-Î² Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells. PloS one\| PubMed ID: 22299047	2012
Injection of Amniotic Fluid Stem Cells Delays Progression of Renal Fibrosis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22302195	2012